The hypoxia-inducible factor-1[alpha] is a negative factor for tumor therapy

Tumor hypoxia negatively regulates cell growth and causes a more malignant phenotype by increasing the expression of genes encoding angiogenic, metabolic and metastatic factors. Of clinical importance, insufficient tumor oxygenation affects the efficiency of chemotherapy and radiotherapy by poorly u...

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Veröffentlicht in:	Oncogene 2003-05, Vol.22 (21), p.3213
Hauptverfasser:	Unruh, Annika, Ressel, Anke, Mohamed, Hamid G, Johnson, Randall S, Nadrowitz, Roger, Richter, Eckart, Katschinski, Dörthe M, Wenger, Roland H
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Cell growth Chemotherapy Genes Hypoxia Medical prognosis Physiology Radiation therapy Stem cells Tumors
Online-Zugang:	Volltext
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