Low plasma levels of matrix metalloproteinase 9 permit increased tumor angiogenesis

Angiogenesis is essential for tumor growth and blocking this process might be a valid tool for the control of cancer growth. We showed previously that tumor angiogenesis in integrin alpha1-null mice is reduced compared to that of wild type animals and that over-expression of matrix metalloproteinase...

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Veröffentlicht in:	Oncogene 2002-01, Vol.21 (2), p.272-281
Hauptverfasser:	POZZI, Ambra, LEVINE, Wendy F, GARDNER, Humphrey A
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenesis Angiostatins Animals Antigens, CD - genetics Antigens, CD - physiology Antineoplastic Agents - pharmacology Biological and medical sciences Carcinoma, Renal Cell - blood supply Carcinoma, Renal Cell - genetics Carcinoma, Renal Cell - pathology Cell Division - drug effects Cell growth Cell physiology Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes Colonic Neoplasms - blood supply Colonic Neoplasms - genetics Colonic Neoplasms - pathology Doxycycline - blood Doxycycline - toxicity Endothelium, Vascular - cytology Endothelium, Vascular - physiology Extracellular matrix Fundamental and applied biological sciences. Psychology Growth Substances - blood Integrin alpha1 Kidney Neoplasms - blood supply Kidney Neoplasms - genetics Kidney Neoplasms - pathology Lung cancer Matrix Metalloproteinase 9 - blood Mice Mice, Inbred BALB C Mice, Inbred Strains Mice, Knockout Molecular and cellular biology Neovascularization, Pathologic - blood Peptide Fragments - pharmacology Plasma Plasminogen - pharmacology Tumor Cells, Cultured
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