NF-[kappa]B-dependent MnSOD expression protects adenocarcinoma cells from TNF-[alpha]-induced apoptosis

NF-kappaB is known to exert a cytoprotective action against TNF-alpha-induced apoptosis. To study the role of NF-kappaB in various TNF-alpha-treated epithelial cell lines, we generated stable transfectants overexpressing a mutated unresponsive form of the IkappaBalpha inhibitor (MT cells). As NF-kap...

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Veröffentlicht in:	Oncogene 2002-05, Vol.21 (24), p.3917
Hauptverfasser:	Delhalle, Sylvie, Deregowski, Valérie, Benoit, Valérie, Marie-Paule Merville, Bours, Vincent
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Cancer Cell death Cytokines Enzymes Genes Phosphorylation Proteins Transcription factors Tumor necrosis factor-TNF
Online-Zugang:	Volltext
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