PGC‐1α deficiency causes spontaneous kidney inflammation and increases the severity of nephrotoxic AKI

PGC‐1α (peroxisome proliferator‐activated receptor gamma coactivator‐1α, PPARGC1A) regulates the expression of genes involved in energy homeostasis and mitochondrial biogenesis. Here we identify inactivation of the transcriptional regulator PGC‐1α as a landmark for experimental nephrotoxic acute kid...

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Veröffentlicht in:	The Journal of pathology 2019-09, Vol.249 (1), p.65-78
Hauptverfasser:	Fontecha‐Barriuso, Miguel, Martín‐Sánchez, Diego, Martinez‐Moreno, Julio M, Carrasco, Susana, Ruiz‐Andrés, Olga, Monsalve, Maria, Sanchez‐Ramos, Cristina, Gómez, Manuel J, Ruiz‐Ortega, Marta, Sánchez‐Niño, Maria D, Cannata‐Ortiz, Pablo, Cabello, Ramiro, Gonzalez‐Enguita, Carmen, Ortiz, Alberto, Sanz, Ana B
Format:	Artikel
Sprache:	eng
Schlagworte:	acute kidney injury Acute Kidney Injury - chemically induced Acute Kidney Injury - genetics Acute Kidney Injury - metabolism Acute Kidney Injury - pathology Animals Apoptosis Cell activation Cell Death Cell Line Cell Proliferation Cytokines - metabolism Disease Models, Animal Energy balance Female Folic Acid Gene expression Genes Homeostasis Humans Inactivation Inflammation Inflammation Mediators - metabolism Injury analysis Kidney - metabolism Kidney - pathology Kidney - physiopathology Kidneys Lipocalin-2 - genetics Lipocalin-2 - metabolism Mice Mice, Inbred C57BL Mice, Knockout Mitochondria Mitochondria - genetics Mitochondria - metabolism Mitochondria - pathology Nephritis, Interstitial - genetics Nephritis, Interstitial - metabolism Nephritis, Interstitial - pathology Nephritis, Interstitial - physiopathology Organelle Biogenesis Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha - deficiency Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha - genetics Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha - metabolism PGC‐1α proximal tubule Renal function Severity of Illness Index Signal Transduction
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