Linking bioenergetic function of mitochondria to tissue-specific molecular fingerprints

Mitochondria are dynamic organelles with diverse functions in tissues such as liver and skeletal muscle. To unravel the mitochondrial contribution to tissue-specific physiology, we performed a systematic comparison of the mitochondrial proteome and lipidome of mice and assessed the consequences here...

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Veröffentlicht in:	American journal of physiology: endocrinology and metabolism 2019-08, Vol.317 (2), p.E374-E387
Hauptverfasser:	Kappler, Lisa, Hoene, Miriam, Hu, Chunxiu, von Toerne, Christine, Li, Jia, Bleher, Daniel, Hoffmann, Christoph, Böhm, Anja, Kollipara, Laxmikanth, Zischka, Hans, Königsrainer, Alfred, Häring, Hans-Ulrich, Peter, Andreas, Xu, Guowang, Sickmann, Albert, Hauck, Stefanie M, Weigert, Cora, Lehmann, Rainer
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals ATP synthase Bioenergetics Electron transfer Electron transport chain Energy Metabolism - physiology Fatty acids Female Gluconeogenesis Humans Ketogenesis Lipids Liver Liver - chemistry Liver - metabolism Male Mice Mice, Inbred C57BL Mitochondria Mitochondria - metabolism Mitochondria, Liver - metabolism Mitochondria, Muscle - metabolism Mitochondrial Proteins - analysis Mitochondrial Proteins - metabolism Muscle, Skeletal - chemistry Muscle, Skeletal - metabolism Muscles Musculoskeletal system Organ Specificity Organelles Oxidation Oxidative phosphorylation Peptide Mapping - methods Phosphorylation Protein composition Proteins Proteome - analysis Proteome - metabolism Proteomics Pyruvic acid Quinone oxidoreductase Quinones Respiration Respirometry Skeletal muscle Substrate preferences Substrates
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