Survival of oral tongue squamous cell carcinoma in young adults
Background Small cohort studies have suggested oral tongue squamous cell carcinoma (OTSCC) could be associated with worse prognosis in individuals younger than 40. Methods We compared the survival of all OTSCC cases in the National Cancer Database under 40 years old with those older than 40, excludi...
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| Veröffentlicht in: | Head & neck 2019-09, Vol.41 (9), p.2960-2968 |
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| creator | Oliver, Jamie R. Wu, S. Peter Chang, Clifford M. Roden, Dylan F. Wang, Binhuan Hu, Kenneth S. Schreiber, David Givi, Babak |
| description | Background
Small cohort studies have suggested oral tongue squamous cell carcinoma (OTSCC) could be associated with worse prognosis in individuals younger than 40.
Methods
We compared the survival of all OTSCC cases in the National Cancer Database under 40 years old with those older than 40, excluding patients over 70. Cox regression and propensity score matched (PSM) survival analyses were performed.
Results
A total of 22 930 OTSCC patients were identified. The under 40 group consisted of 2566 (9.9%) cases; 20664 were 40 to 70 (90.1%). Most were male (13 713, 59.8%), stage I‐II (12 754, 72.4%), and treated by surgery alone (13 973, 63.2%). Survival in patients under 40 was higher (79.6% vs 69.5%, P |
| doi_str_mv | 10.1002/hed.25772 |
| format | Article |
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Small cohort studies have suggested oral tongue squamous cell carcinoma (OTSCC) could be associated with worse prognosis in individuals younger than 40.
Methods
We compared the survival of all OTSCC cases in the National Cancer Database under 40 years old with those older than 40, excluding patients over 70. Cox regression and propensity score matched (PSM) survival analyses were performed.
Results
A total of 22 930 OTSCC patients were identified. The under 40 group consisted of 2566 (9.9%) cases; 20664 were 40 to 70 (90.1%). Most were male (13 713, 59.8%), stage I‐II (12 754, 72.4%), and treated by surgery alone (13 973, 63.2%). Survival in patients under 40 was higher (79.6% vs 69.5%, P < .001). In PSM analysis (n = 2928) controlling for all 10 significant factors in multivariate regression, patients under 40 had a 9% higher 5‐year survival (77.1% vs 68.2%, P < .001).
Conclusion
Contrary to the prior reports, younger patients with OTSCC did not have worse survival in the National Cancer Database.</description><identifier>ISSN: 1043-3074</identifier><identifier>EISSN: 1097-0347</identifier><identifier>DOI: 10.1002/hed.25772</identifier><identifier>PMID: 30985036</identifier><language>eng</language><publisher>Hoboken, USA: John Wiley & Sons, Inc</publisher><subject>age ; Head and neck ; Medical prognosis ; Oral cancer ; Squamous cell carcinoma ; Surgery ; Tongue ; young ; Young adults</subject><ispartof>Head & neck, 2019-09, Vol.41 (9), p.2960-2968</ispartof><rights>2019 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4192-aa0c2c7bb93a710e5584767c7a4a5f15241a8bea063abe5960edc19ba91c47423</citedby><cites>FETCH-LOGICAL-c4192-aa0c2c7bb93a710e5584767c7a4a5f15241a8bea063abe5960edc19ba91c47423</cites><orcidid>0000-0002-8221-5077 ; 0000-0002-2664-7756</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fhed.25772$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fhed.25772$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30985036$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Oliver, Jamie R.</creatorcontrib><creatorcontrib>Wu, S. Peter</creatorcontrib><creatorcontrib>Chang, Clifford M.</creatorcontrib><creatorcontrib>Roden, Dylan F.</creatorcontrib><creatorcontrib>Wang, Binhuan</creatorcontrib><creatorcontrib>Hu, Kenneth S.</creatorcontrib><creatorcontrib>Schreiber, David</creatorcontrib><creatorcontrib>Givi, Babak</creatorcontrib><title>Survival of oral tongue squamous cell carcinoma in young adults</title><title>Head & neck</title><addtitle>Head Neck</addtitle><description>Background
Small cohort studies have suggested oral tongue squamous cell carcinoma (OTSCC) could be associated with worse prognosis in individuals younger than 40.
Methods
We compared the survival of all OTSCC cases in the National Cancer Database under 40 years old with those older than 40, excluding patients over 70. Cox regression and propensity score matched (PSM) survival analyses were performed.
Results
A total of 22 930 OTSCC patients were identified. The under 40 group consisted of 2566 (9.9%) cases; 20664 were 40 to 70 (90.1%). Most were male (13 713, 59.8%), stage I‐II (12 754, 72.4%), and treated by surgery alone (13 973, 63.2%). Survival in patients under 40 was higher (79.6% vs 69.5%, P < .001). In PSM analysis (n = 2928) controlling for all 10 significant factors in multivariate regression, patients under 40 had a 9% higher 5‐year survival (77.1% vs 68.2%, P < .001).
Conclusion
Contrary to the prior reports, younger patients with OTSCC did not have worse survival in the National Cancer Database.</description><subject>age</subject><subject>Head and neck</subject><subject>Medical prognosis</subject><subject>Oral cancer</subject><subject>Squamous cell carcinoma</subject><subject>Surgery</subject><subject>Tongue</subject><subject>young</subject><subject>Young adults</subject><issn>1043-3074</issn><issn>1097-0347</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNp1kD1PwzAQhi0EoqUw8AeQJSaGtP5KnEwIlUKRKjEAs3VxnZIqiVu7Lsq_JyXtyPTenR69Jz0I3VIypoSwybdZjlksJTtDQ0oyGREu5PlhFjziRIoBuvJ-TQjhiWCXaMBJlsbdMkSPH8Htyz1U2BbYui53tlkFg_02QG2Dx9pUFdbgdNnYGnDZ4NaGZoVhGaqdv0YXBVTe3BxzhL5eZp_TebR4f32bPi0iLWjGIgCimZZ5nnGQlJg4ToVMpJYgIC5ozASFNDdAEg65ibOEmKWmWQ4Z1UIKxkfovu_dOLsNxu_U2gbXdC8VY5LRlHF6oB56SjvrvTOF2riyBtcqStRBlepUqT9VHXt3bAx53V1P5MlNB0x64KesTPt_k5rPnvvKX5bvcY4</recordid><startdate>201909</startdate><enddate>201909</enddate><creator>Oliver, Jamie R.</creator><creator>Wu, S. Peter</creator><creator>Chang, Clifford M.</creator><creator>Roden, Dylan F.</creator><creator>Wang, Binhuan</creator><creator>Hu, Kenneth S.</creator><creator>Schreiber, David</creator><creator>Givi, Babak</creator><general>John Wiley & Sons, Inc</general><general>Wiley Subscription Services, Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7TK</scope><scope>K9.</scope><orcidid>https://orcid.org/0000-0002-8221-5077</orcidid><orcidid>https://orcid.org/0000-0002-2664-7756</orcidid></search><sort><creationdate>201909</creationdate><title>Survival of oral tongue squamous cell carcinoma in young adults</title><author>Oliver, Jamie R. ; Wu, S. Peter ; Chang, Clifford M. ; Roden, Dylan F. ; Wang, Binhuan ; Hu, Kenneth S. ; Schreiber, David ; Givi, Babak</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4192-aa0c2c7bb93a710e5584767c7a4a5f15241a8bea063abe5960edc19ba91c47423</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>age</topic><topic>Head and neck</topic><topic>Medical prognosis</topic><topic>Oral cancer</topic><topic>Squamous cell carcinoma</topic><topic>Surgery</topic><topic>Tongue</topic><topic>young</topic><topic>Young adults</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Oliver, Jamie R.</creatorcontrib><creatorcontrib>Wu, S. Peter</creatorcontrib><creatorcontrib>Chang, Clifford M.</creatorcontrib><creatorcontrib>Roden, Dylan F.</creatorcontrib><creatorcontrib>Wang, Binhuan</creatorcontrib><creatorcontrib>Hu, Kenneth S.</creatorcontrib><creatorcontrib>Schreiber, David</creatorcontrib><creatorcontrib>Givi, Babak</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><jtitle>Head & neck</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Oliver, Jamie R.</au><au>Wu, S. Peter</au><au>Chang, Clifford M.</au><au>Roden, Dylan F.</au><au>Wang, Binhuan</au><au>Hu, Kenneth S.</au><au>Schreiber, David</au><au>Givi, Babak</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Survival of oral tongue squamous cell carcinoma in young adults</atitle><jtitle>Head & neck</jtitle><addtitle>Head Neck</addtitle><date>2019-09</date><risdate>2019</risdate><volume>41</volume><issue>9</issue><spage>2960</spage><epage>2968</epage><pages>2960-2968</pages><issn>1043-3074</issn><eissn>1097-0347</eissn><abstract>Background
Small cohort studies have suggested oral tongue squamous cell carcinoma (OTSCC) could be associated with worse prognosis in individuals younger than 40.
Methods
We compared the survival of all OTSCC cases in the National Cancer Database under 40 years old with those older than 40, excluding patients over 70. Cox regression and propensity score matched (PSM) survival analyses were performed.
Results
A total of 22 930 OTSCC patients were identified. The under 40 group consisted of 2566 (9.9%) cases; 20664 were 40 to 70 (90.1%). Most were male (13 713, 59.8%), stage I‐II (12 754, 72.4%), and treated by surgery alone (13 973, 63.2%). Survival in patients under 40 was higher (79.6% vs 69.5%, P < .001). In PSM analysis (n = 2928) controlling for all 10 significant factors in multivariate regression, patients under 40 had a 9% higher 5‐year survival (77.1% vs 68.2%, P < .001).
Conclusion
Contrary to the prior reports, younger patients with OTSCC did not have worse survival in the National Cancer Database.</abstract><cop>Hoboken, USA</cop><pub>John Wiley & Sons, Inc</pub><pmid>30985036</pmid><doi>10.1002/hed.25772</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-8221-5077</orcidid><orcidid>https://orcid.org/0000-0002-2664-7756</orcidid></addata></record> |
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| ispartof | Head & neck, 2019-09, Vol.41 (9), p.2960-2968 |
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| language | eng |
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| source | Wiley Online Library Journals Frontfile Complete |
| subjects | age Head and neck Medical prognosis Oral cancer Squamous cell carcinoma Surgery Tongue young Young adults |
| title | Survival of oral tongue squamous cell carcinoma in young adults |
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