Antioxidant and Anticancer potential of Methanolic extract of Kigelia pinnata fruits against DENA induced Hepatocellular Carcinoma in rats

Comparative analysis on the KPME treatment groups revealed that high dose (500mg/kg body weight showed significant reduction in the serum level of enzymes. [...]the methanolic extract of Kigelia pinnata possesses anti-hepatocellular activity which may be due to its hepatoprotective action. Animals: Male Sprague Dawley rats weighing between 200-250g maintained at room temperature with 12 hour cycles of light and dark having access to food (as per the selected models) and tap water ad libitum in the animal house facility of Krupanidhi College of Pharmacy, Chikkabellandur, Carmelaram Post, Varthur Hobli, Bengaluru, India as per CPSCEA guideline were used after the approval from IAEC (2016/PCOL/03/KCP/IAEC) for the study. Free radicals like Reactive Oxygen Species (ROS) and Reactive Nitrogen Species (RNS), highly contribute to the initiation and progression of several diseases, such as, cancer, cardiovascular diseases, Alzheimer's disease, Parkinsonism, atherosclerosis, and liver diseases. Since ROS are involved in pathways regulating genes transcription, protein expression, cell apoptosis, and hepatic stellate cell activation; oxidative stress produced due to the imbalance in generation and elimination of ROS results in initiation and progression of various liver diseases such as alcohol liver disease, chronic viral hepatitis, steatohepatitis, etc.