Cytotoxic Activity of Ethanol and Ethyl Acetate Extract of Kenikir ( Cosmos   caudatus ) against Cervical Cancer Cell Line (HELA)

According to data from the WHO, cancer causes the death of at least 8.8 million people in 2015 and 1 of 6 people in the world die of cancer. The data resulted from the cytotoxic test in this study were the percentage of the number of surviving HeLa cancer cells (or percentage of cell viability) after addition a series concentration of kenikir extract leaves. [22] Tarapdhar reported that quercetin could induce Caco-2 and HT-29 colon cancer apoptosis and HL-60 leukemia cancer cells by stimulating the release of cytochrome c from mitochondria. The previous test showed that the IC50 value of cytotoxic activity of methanol extract of kenikir leaves on breast cancer cells TD47 was 344.91 ppm [24] and of cytotoxic activity of ethanol extract of kenikir leaves on P388 mouse leukemia cells was 25 ppm.