Quantification of a cell-mediated immune response against varicella zoster virus by assessing responder CD4 high memory cell proliferation in activated whole blood cultures

Herpes zoster (HZ) is caused by reactivation of a latent varicella zoster virus (VZV). The potential to develop HZ increases with age due to waning of memory cell-mediated immunity (CMI), mainly the CD4 response. Therefore, VZV-CD4-memory T cells (CD4-M) count in blood could serve as a barometer for...

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Veröffentlicht in:	Vaccine 2019-08, Vol.37 (36), p.5225
Hauptverfasser:	Haredy, Ahmad M, Takei, Michihiro, Iwamoto, Shin-Ichi, Ohno, Masafumi, Kosaka, Mitsuyo, Hirota, Kazue, Koketsu, Ritsuko, Okuno, Toshiomi, Ikuta, Kazuyoshi, Yamanishi, Koichi, Ebina, Hirotaka
Format:	Artikel
Sprache:	eng
Schlagworte:	Activation Adults Antigens Barometers Blood Blood culture CCR7 protein CD3 antigen CD4 antigen Cell culture Cell growth Cell proliferation Cell-mediated immunity Chicken pox Children Computer memory Cytokines Cytotoxicity Effector cells Experiments Flow cytometry Geriatrics Granzyme B Herpes zoster Immune response Immune response (cell-mediated) Immune system Immunity Immunoglobulins Immunological memory Infections Lymphocytes Lymphocytes B Lymphocytes T M cells Memory cells Methods Older people Phenotypes Vaccination Vaccines Varicella Viruses Young adults
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