A clinicopathologic study of surgically resected metastatic lesions of brain: A single institutional experience
Introduction: One of the most common tumors of the brain are metastatic lesions. They can present as cancer of unknown primary (CUP) and require careful determination of the site of origin of the primary. Histopathologic and immunohistochemical analysis helps to determine the primary site. Aim: To s...
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| Veröffentlicht in: | Neurology India 2019-05, Vol.67 (3), p.749-754 |
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| description | Introduction: One of the most common tumors of the brain are metastatic lesions. They can present as cancer of unknown primary (CUP) and require careful determination of the site of origin of the primary. Histopathologic and immunohistochemical analysis helps to determine the primary site.
Aim: To study the clinicopathological features of metastatic tumors of the brain.
Materials and Methods: All cases of surgically resected brain metastasis (solid tumor metastasis) from January 2013 to April 2015 were included in the study. The clinical details including age, gender, clinical features, and location were taken from medical records. The histopathology slides were retrieved and reviewed along with clinical and imaging findings from medical records. Immunohistochemistry was performed wherever necessary.
Results: Out of 1662 resected brain lesions during the study period, 69 accounted for central nervous system metastasis, of which 36 were brain metastasis and 33 were isolated spinal cord metastasis. In the 36 brain metastasis cases, 19 were cases with an unknown primary. Carcinoma lung (47.2%) was found to be the most common primary malignancy. Immunohistochemistry with cytokeratin (CK)7, CK20, and thyroid transcription factor (TTF) 1 as a primary panel in metastatic tumors is highly recommended.
Conclusion: Metastatic tumors accounted for 4.1% of intracranial lesions. Histopathologic pattern and immunohistochemistry aid in the accurate diagnosis of the original site of malignancy. |
| doi_str_mv | 10.4103/0028-3886.263251 |
| format | Article |
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Aim: To study the clinicopathological features of metastatic tumors of the brain.
Materials and Methods: All cases of surgically resected brain metastasis (solid tumor metastasis) from January 2013 to April 2015 were included in the study. The clinical details including age, gender, clinical features, and location were taken from medical records. The histopathology slides were retrieved and reviewed along with clinical and imaging findings from medical records. Immunohistochemistry was performed wherever necessary.
Results: Out of 1662 resected brain lesions during the study period, 69 accounted for central nervous system metastasis, of which 36 were brain metastasis and 33 were isolated spinal cord metastasis. In the 36 brain metastasis cases, 19 were cases with an unknown primary. Carcinoma lung (47.2%) was found to be the most common primary malignancy. Immunohistochemistry with cytokeratin (CK)7, CK20, and thyroid transcription factor (TTF) 1 as a primary panel in metastatic tumors is highly recommended.
Conclusion: Metastatic tumors accounted for 4.1% of intracranial lesions. Histopathologic pattern and immunohistochemistry aid in the accurate diagnosis of the original site of malignancy.</description><identifier>ISSN: 0028-3886</identifier><identifier>EISSN: 1998-4022</identifier><identifier>DOI: 10.4103/0028-3886.263251</identifier><identifier>PMID: 31347548</identifier><language>eng</language><publisher>India: Wolters Kluwer India Pvt. Ltd</publisher><subject>Adenocarcinoma - diagnosis ; Adenocarcinoma - epidemiology ; Adenocarcinoma - pathology ; Adenocarcinoma - secondary ; Adolescent ; Adult ; Aged ; Brain ; Brain cancer ; Brain damage ; Brain Neoplasms - diagnosis ; Brain Neoplasms - epidemiology ; Brain Neoplasms - pathology ; Brain Neoplasms - secondary ; Brain tumors ; Breast cancer ; Cancer ; Cancer metastasis ; Carcinoma, Squamous Cell - diagnosis ; Carcinoma, Squamous Cell - epidemiology ; Carcinoma, Squamous Cell - pathology ; Carcinoma, Squamous Cell - secondary ; Care and treatment ; Chemotherapy ; Child ; Female ; Histopathology ; Humans ; Male ; Medical prognosis ; Metastasis ; Middle Aged ; Pathological histology ; Patient outcomes ; Retrospective Studies ; Spinal Cord Neoplasms - diagnosis ; Spinal Cord Neoplasms - epidemiology ; Thyroid gland ; Tumor removal ; Tumors ; Young Adult</subject><ispartof>Neurology India, 2019-05, Vol.67 (3), p.749-754</ispartof><rights>COPYRIGHT 2019 Medknow Publications and Media Pvt. Ltd.</rights><rights>2019. This work is published under https://creativecommons.org/licenses/by-nc-sa/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c493p-a69d605d759ed5303b707f8905a33c84015e6aed45d497b34d782ca18e1d6ada3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31347548$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sangati, Lavanya</creatorcontrib><creatorcontrib>Alugolu, Rajesh</creatorcontrib><creatorcontrib>Bhattacharjee, Suchanda</creatorcontrib><creatorcontrib>Vijaya Saradhi, M</creatorcontrib><creatorcontrib>Sahu, B</creatorcontrib><creatorcontrib>Uppin, Megha</creatorcontrib><creatorcontrib>Sadashivudu, G</creatorcontrib><creatorcontrib>Irukulla, Monica</creatorcontrib><title>A clinicopathologic study of surgically resected metastatic lesions of brain: A single institutional experience</title><title>Neurology India</title><addtitle>Neurol India</addtitle><description>Introduction: One of the most common tumors of the brain are metastatic lesions. They can present as cancer of unknown primary (CUP) and require careful determination of the site of origin of the primary. Histopathologic and immunohistochemical analysis helps to determine the primary site.
Aim: To study the clinicopathological features of metastatic tumors of the brain.
Materials and Methods: All cases of surgically resected brain metastasis (solid tumor metastasis) from January 2013 to April 2015 were included in the study. The clinical details including age, gender, clinical features, and location were taken from medical records. The histopathology slides were retrieved and reviewed along with clinical and imaging findings from medical records. Immunohistochemistry was performed wherever necessary.
Results: Out of 1662 resected brain lesions during the study period, 69 accounted for central nervous system metastasis, of which 36 were brain metastasis and 33 were isolated spinal cord metastasis. In the 36 brain metastasis cases, 19 were cases with an unknown primary. Carcinoma lung (47.2%) was found to be the most common primary malignancy. Immunohistochemistry with cytokeratin (CK)7, CK20, and thyroid transcription factor (TTF) 1 as a primary panel in metastatic tumors is highly recommended.
Conclusion: Metastatic tumors accounted for 4.1% of intracranial lesions. Histopathologic pattern and immunohistochemistry aid in the accurate diagnosis of the original site of malignancy.</description><subject>Adenocarcinoma - diagnosis</subject><subject>Adenocarcinoma - epidemiology</subject><subject>Adenocarcinoma - pathology</subject><subject>Adenocarcinoma - secondary</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Brain</subject><subject>Brain cancer</subject><subject>Brain damage</subject><subject>Brain Neoplasms - diagnosis</subject><subject>Brain Neoplasms - epidemiology</subject><subject>Brain Neoplasms - pathology</subject><subject>Brain Neoplasms - secondary</subject><subject>Brain tumors</subject><subject>Breast cancer</subject><subject>Cancer</subject><subject>Cancer metastasis</subject><subject>Carcinoma, Squamous Cell - diagnosis</subject><subject>Carcinoma, Squamous Cell - epidemiology</subject><subject>Carcinoma, Squamous Cell - pathology</subject><subject>Carcinoma, Squamous Cell - secondary</subject><subject>Care and treatment</subject><subject>Chemotherapy</subject><subject>Child</subject><subject>Female</subject><subject>Histopathology</subject><subject>Humans</subject><subject>Male</subject><subject>Medical prognosis</subject><subject>Metastasis</subject><subject>Middle Aged</subject><subject>Pathological histology</subject><subject>Patient outcomes</subject><subject>Retrospective Studies</subject><subject>Spinal Cord Neoplasms - diagnosis</subject><subject>Spinal Cord Neoplasms - epidemiology</subject><subject>Thyroid gland</subject><subject>Tumor removal</subject><subject>Tumors</subject><subject>Young Adult</subject><issn>0028-3886</issn><issn>1998-4022</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNptks9vFCEUx4nR2LV692Qm8TwrDDAD3jb1Z9LEi54JC29WWgZGYLLd_14221abbDiQx_t8v4H3BaG3BK8ZwfQDxp1oqRD9uutpx8kztCJSipbhrnuOVo_tC_Qq55taUkq6l-iCEsoGzsQKxU1jvAvOxFmX39HHnTNNLos9NHFs8pJqrb0_NAkymAK2maDoXHSpnIfsYshHcpu0Cx-bTZNd2HloXMjFlaXUvvYN3M2QHAQDr9GLUfsMb-73S_Try-efV9_a6x9fv19trlvDJJ1b3UvbY24HLsFyiul2wMMoJOaaUiMYJhx6DZZxy-SwpcwOojOaCCC211bTS_T-5Dun-GeBXNRNXFK9S1Zd10vB-zqxf9ROe1AujLEkbSaXjdpwySWlgxwq1Z6hdhAgaR8DjK4eP-HXZ_i6LEx10OcE-CQwKeacYFRzcpNOB0WwOgatjkmqY5LqFHSVvLt_37KdwD4KHpKtwKcTsI--QMq3ftlDUpW9DXH_xLj9z1gNTKqNevgT9C90QriF</recordid><startdate>20190501</startdate><enddate>20190501</enddate><creator>Sangati, Lavanya</creator><creator>Alugolu, Rajesh</creator><creator>Bhattacharjee, Suchanda</creator><creator>Vijaya Saradhi, M</creator><creator>Sahu, B</creator><creator>Uppin, Megha</creator><creator>Sadashivudu, G</creator><creator>Irukulla, Monica</creator><general>Wolters Kluwer India Pvt. 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They can present as cancer of unknown primary (CUP) and require careful determination of the site of origin of the primary. Histopathologic and immunohistochemical analysis helps to determine the primary site.
Aim: To study the clinicopathological features of metastatic tumors of the brain.
Materials and Methods: All cases of surgically resected brain metastasis (solid tumor metastasis) from January 2013 to April 2015 were included in the study. The clinical details including age, gender, clinical features, and location were taken from medical records. The histopathology slides were retrieved and reviewed along with clinical and imaging findings from medical records. Immunohistochemistry was performed wherever necessary.
Results: Out of 1662 resected brain lesions during the study period, 69 accounted for central nervous system metastasis, of which 36 were brain metastasis and 33 were isolated spinal cord metastasis. In the 36 brain metastasis cases, 19 were cases with an unknown primary. Carcinoma lung (47.2%) was found to be the most common primary malignancy. Immunohistochemistry with cytokeratin (CK)7, CK20, and thyroid transcription factor (TTF) 1 as a primary panel in metastatic tumors is highly recommended.
Conclusion: Metastatic tumors accounted for 4.1% of intracranial lesions. Histopathologic pattern and immunohistochemistry aid in the accurate diagnosis of the original site of malignancy.</abstract><cop>India</cop><pub>Wolters Kluwer India Pvt. Ltd</pub><pmid>31347548</pmid><doi>10.4103/0028-3886.263251</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adenocarcinoma - diagnosis Adenocarcinoma - epidemiology Adenocarcinoma - pathology Adenocarcinoma - secondary Adolescent Adult Aged Brain Brain cancer Brain damage Brain Neoplasms - diagnosis Brain Neoplasms - epidemiology Brain Neoplasms - pathology Brain Neoplasms - secondary Brain tumors Breast cancer Cancer Cancer metastasis Carcinoma, Squamous Cell - diagnosis Carcinoma, Squamous Cell - epidemiology Carcinoma, Squamous Cell - pathology Carcinoma, Squamous Cell - secondary Care and treatment Chemotherapy Child Female Histopathology Humans Male Medical prognosis Metastasis Middle Aged Pathological histology Patient outcomes Retrospective Studies Spinal Cord Neoplasms - diagnosis Spinal Cord Neoplasms - epidemiology Thyroid gland Tumor removal Tumors Young Adult |
| title | A clinicopathologic study of surgically resected metastatic lesions of brain: A single institutional experience |
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