N-Propargyltetrahydrocarbazoles and N-propargyltetrahydro-γ-carbolines in 1,3-cycloaddition with azide-containing pharmacophores

N-Propargyltetrahydrocarbazoles and N-propargyltetrahydro-γ-carbolines in 1,3-cycloaddition with azide-containing pharmacophores

A modification of tetrahydrocarbazoles and tetrahydro-γ-carbolines with pharmacophore ligands was performed based on the copper-catalyzed 1,3-dipolar cycloaddition of their N -propargyl derivatives to azide-containing carbazoles, tetrahydrocarbazoles, 1-aminoadamantanes, and phenothiazine.

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Veröffentlicht in:Russian chemical bulletin 2019-07, Vol.68 (7), p.1424-1428
Hauptverfasser: Sokolov, V. B., Aksinenko, A. Yu, Epishina, T. A., Goreva, T. V.
Format: Artikel
Sprache:eng
Schlagworte:
Carbazoles
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Cycloaddition
Full Articles
Inorganic Chemistry
Organic Chemistry
Pharmacology
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Zusammenfassung:A modification of tetrahydrocarbazoles and tetrahydro-γ-carbolines with pharmacophore ligands was performed based on the copper-catalyzed 1,3-dipolar cycloaddition of their N -propargyl derivatives to azide-containing carbazoles, tetrahydrocarbazoles, 1-aminoadamantanes, and phenothiazine.
ISSN:1066-5285
1573-9171
DOI:10.1007/s11172-019-2571-7