The ascending pathophysiology of cholestatic liver disease

In this review we develop the argument that cholestatic liver diseases, particularly primary biliary cholangitis and primary sclerosing cholangitis (PSC), evolve over time with anatomically an ascending course of the disease process. The first and early lesions are in “downstream” bile ducts. This e...

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Veröffentlicht in:	Hepatology (Baltimore, Md.) Md.), 2017-02, Vol.65 (2), p.722-738
Hauptverfasser:	Jansen, Peter L.M., Ghallab, Ahmed, Vartak, Nachiket, Reif, Raymond, Schaap, Frank G., Hampe, Jochen, Hengstler, Jan G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptation, Physiological Animals Anti-Bacterial Agents - therapeutic use Anti-Inflammatory Agents - therapeutic use Bile Bile Acids and Salts - blood Bile ducts Bile Ducts - pathology Biomarkers Biomarkers - blood Cholangitis Cholangitis, Sclerosing - drug therapy Cholangitis, Sclerosing - physiopathology Cholestasis Cholestasis - blood Cholestasis - drug therapy Cholestasis - physiopathology Clinical trials Cytochrome P450 Disease Disease Progression Drugs Gallbladder Gallbladder diseases Hepatology Humans Inflammation Intestine Liver Liver diseases Liver Diseases - blood Liver Diseases - drug therapy Liver Diseases - physiopathology Mice Parenchyma Pathophysiology Prognosis Sodium Toxicity Ursodeoxycholic acid
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