Genome‐wide DNA methylation changes in transformed foci induced by nongenotoxic carcinogens

In vitro cell transformation assays (CTA) have been proposed as a method to identify possible nongenotoxic carcinogens. However, the current protocols do not provide information on the mechanism of action of the test articles. In this study, we combined an in vitro Bhas 42 CTA and sequencing‐based D...

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Veröffentlicht in:	Environmental and molecular mutagenesis 2019-08, Vol.60 (7), p.576-587
Hauptverfasser:	Hwang, Sung‐Hee, Yeom, Hojin, Eom, Seong Yun, Lee, Yong‐Moon, Lee, Michael
Format:	Artikel
Sprache:	eng
Schlagworte:	Acids Animals Autophagy BALB 3T3 Cells Basal cell carcinoma Bhas 42 Bile Cadmium Cadmium chloride Cancer Carcinogens Carcinogens - toxicity Cell Transformation, Neoplastic - chemically induced Chloride CpG islands CpG Islands - drug effects CpG Islands - genetics Deoxyribonucleic acid DNA DNA - drug effects DNA - genetics DNA fingerprinting DNA methylation DNA Methylation - drug effects DNA Methylation - genetics DNA sequencing Encyclopedias Genes Genetic transformation Genome - drug effects Genome - genetics Genome-Wide Association Study - methods Genomes In vitro cell transformation assay integrated approaches to testing and assessment (IATA) MBD‐Seq methylation Mice mRNA Mutagens - toxicity Neoplasms - chemically induced Neoplasms - genetics nongenotoxic carcinogen Phagocytosis RNA transport Sensitivity analysis Signal Transduction - drug effects Signal Transduction - genetics Skin cancer Wnt protein
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