Gastroprotective effect of cilostazol against ethanol- and pylorus ligation–induced gastric lesions in rats

Despite the availability of effective antiulcer medications, their suboptimal safety profile ignites the search for alternative/complementary treatments. Drug repositioning is an attractive, efficient, and low-risk strategy. Cilostazol, a clinically used phosphodiesterase 3 inhibitor, has pronounced...

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Veröffentlicht in:	Naunyn-Schmiedeberg's archives of pharmacology 2019-12, Vol.392 (12), p.1605-1616
Hauptverfasser:	Moawad, Helmy, El Awdan, Sally A., Sallam, Nada A., El-Eraky, Wafaa I, Alkhawlani, Mohammed A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acidic oxides Animals Anti-Ulcer Agents - pharmacology Anti-Ulcer Agents - therapeutic use Apoptosis BAX protein Bcl-2 protein Bcl-x protein Biomedical and Life Sciences Biomedicine Cilostazol - pharmacology Cilostazol - therapeutic use Computational fluid dynamics Cytokines - metabolism Dinoprostone - metabolism Drug dosages Ethanol Gastric juice Gastric mucosa Gastric Mucosa - drug effects Gastric Mucosa - metabolism Gastric Mucosa - pathology Glutathione HSP70 Heat-Shock Proteins - metabolism Hsp70 protein IL-1β Inflammation Interleukin 6 Lesions Male Malondialdehyde Mucin Mucus Neurosciences Nitric oxide Nitric Oxide - metabolism Original Article Oxidative stress Perfusion Pharmacology/Toxicology Phosphodiesterase Prostaglandin E2 Pylorus - surgery Ranitidine Rats, Wistar Stomach Ulcer - drug therapy Stomach Ulcer - etiology Stomach Ulcer - metabolism Stomach Ulcer - pathology Tumor necrosis factor Ulcers
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