An amino-endcapped octadecylsilane silica-based mixed-mode stationary phase for the simultaneous separation of neutral and ionizable components in fixed-dose combinations
An amino-endcapped octadecylsilane silica-based stationary phase (ODS-APS) was prepared for simultaneous separation of neutral and ionizable compounds in fixed-dose combinations. The packing was prepared by a three-step vapor deposition method which involves the reaction of silica particles with (3-...
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| Veröffentlicht in: | Analytical methods 2019-08, Vol.11 (3), p.3898-399 |
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| creator | Li, Yan Zhang, Shuang-Hong Chen, Lei |
| description | An amino-endcapped octadecylsilane silica-based stationary phase (ODS-APS) was prepared for simultaneous separation of neutral and ionizable compounds in fixed-dose combinations. The packing was prepared by a three-step vapor deposition method which involves the reaction of silica particles with (3-aminopropyl)trimethoxysilane and octadecyldimethylchlorosilane in an environmentally friendly process. Physicochemical characterization including Fourier transform infrared spectroscopy, solid-state
13
C CP/MAS NMR spectroscopy and elemental analysis confirmed the successful bonding of both octadecyl and amino-endcapped moieties on the ODS-APS phase. The chromatographic performance of the packing was thoroughly evaluated. In addition, the retention mechanism of acidic compounds on the synthesized phase was systematically evaluated by studying the effects of pH and ionic strength of the mobile phase. Finally, two fixed-dose combinations, losartan potassium/hydrochlorothiazide and B-complex vitamin tablets, were analyzed on the ODS-APS phase. The results demonstrated that the ODS-APS packing provides better peak shape and higher selectivity for separating basic and acidic analytes under neutral conditions compared with the traditional ODS phase. The ODS-APS phase also exhibits superior performance for the simultaneous separation of neutral and ionizable drugs in fixed-dose combinations.
An amino-endcapped octadecylsilane silica-based mixed-mode stationary phase (ODS-APS) was prepared by a three-step vapor deposition method for simultaneous separation of neutral and ionizable compounds in fixed-dose combinations. |
| doi_str_mv | 10.1039/c9ay00660e |
| format | Article |
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13
C CP/MAS NMR spectroscopy and elemental analysis confirmed the successful bonding of both octadecyl and amino-endcapped moieties on the ODS-APS phase. The chromatographic performance of the packing was thoroughly evaluated. In addition, the retention mechanism of acidic compounds on the synthesized phase was systematically evaluated by studying the effects of pH and ionic strength of the mobile phase. Finally, two fixed-dose combinations, losartan potassium/hydrochlorothiazide and B-complex vitamin tablets, were analyzed on the ODS-APS phase. The results demonstrated that the ODS-APS packing provides better peak shape and higher selectivity for separating basic and acidic analytes under neutral conditions compared with the traditional ODS phase. The ODS-APS phase also exhibits superior performance for the simultaneous separation of neutral and ionizable drugs in fixed-dose combinations.
An amino-endcapped octadecylsilane silica-based mixed-mode stationary phase (ODS-APS) was prepared by a three-step vapor deposition method for simultaneous separation of neutral and ionizable compounds in fixed-dose combinations.</description><identifier>ISSN: 1759-9660</identifier><identifier>EISSN: 1759-9679</identifier><identifier>DOI: 10.1039/c9ay00660e</identifier><language>eng</language><publisher>Cambridge: Royal Society of Chemistry</publisher><subject>Fourier transforms ; Hydrochlorothiazide ; Infrared analysis ; Infrared spectroscopy ; Ionic strength ; Ions ; Magnetic resonance spectroscopy ; NMR ; NMR spectroscopy ; Nuclear magnetic resonance ; Packing ; Potassium ; Selectivity ; Separation ; Silica ; Silicon dioxide ; Spectroscopy ; Spectrum analysis ; Stationary phase ; Tablets ; Vapor deposition</subject><ispartof>Analytical methods, 2019-08, Vol.11 (3), p.3898-399</ispartof><rights>Copyright Royal Society of Chemistry 2019</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c318t-b37f427f01a1db3cfe3dd22cee4e60fb45b109f85b11f046338e6dfaed1e8af03</citedby><cites>FETCH-LOGICAL-c318t-b37f427f01a1db3cfe3dd22cee4e60fb45b109f85b11f046338e6dfaed1e8af03</cites><orcidid>0000-0003-3012-3135 ; 0000-0003-4738-9765</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids></links><search><creatorcontrib>Li, Yan</creatorcontrib><creatorcontrib>Zhang, Shuang-Hong</creatorcontrib><creatorcontrib>Chen, Lei</creatorcontrib><title>An amino-endcapped octadecylsilane silica-based mixed-mode stationary phase for the simultaneous separation of neutral and ionizable components in fixed-dose combinations</title><title>Analytical methods</title><description>An amino-endcapped octadecylsilane silica-based stationary phase (ODS-APS) was prepared for simultaneous separation of neutral and ionizable compounds in fixed-dose combinations. The packing was prepared by a three-step vapor deposition method which involves the reaction of silica particles with (3-aminopropyl)trimethoxysilane and octadecyldimethylchlorosilane in an environmentally friendly process. Physicochemical characterization including Fourier transform infrared spectroscopy, solid-state
13
C CP/MAS NMR spectroscopy and elemental analysis confirmed the successful bonding of both octadecyl and amino-endcapped moieties on the ODS-APS phase. The chromatographic performance of the packing was thoroughly evaluated. In addition, the retention mechanism of acidic compounds on the synthesized phase was systematically evaluated by studying the effects of pH and ionic strength of the mobile phase. Finally, two fixed-dose combinations, losartan potassium/hydrochlorothiazide and B-complex vitamin tablets, were analyzed on the ODS-APS phase. The results demonstrated that the ODS-APS packing provides better peak shape and higher selectivity for separating basic and acidic analytes under neutral conditions compared with the traditional ODS phase. The ODS-APS phase also exhibits superior performance for the simultaneous separation of neutral and ionizable drugs in fixed-dose combinations.
An amino-endcapped octadecylsilane silica-based mixed-mode stationary phase (ODS-APS) was prepared by a three-step vapor deposition method for simultaneous separation of neutral and ionizable compounds in fixed-dose combinations.</description><subject>Fourier transforms</subject><subject>Hydrochlorothiazide</subject><subject>Infrared analysis</subject><subject>Infrared spectroscopy</subject><subject>Ionic strength</subject><subject>Ions</subject><subject>Magnetic resonance spectroscopy</subject><subject>NMR</subject><subject>NMR spectroscopy</subject><subject>Nuclear magnetic resonance</subject><subject>Packing</subject><subject>Potassium</subject><subject>Selectivity</subject><subject>Separation</subject><subject>Silica</subject><subject>Silicon dioxide</subject><subject>Spectroscopy</subject><subject>Spectrum analysis</subject><subject>Stationary phase</subject><subject>Tablets</subject><subject>Vapor deposition</subject><issn>1759-9660</issn><issn>1759-9679</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNpFkU9LxDAQxYsouK5evAsBb0I1aWq6PS7L-gcEL3rwVKbJBLO0SU1ScP1IfkqzXdHTC_N-LwPzsuyc0WtGeX0ja9hSKgTFg2zGqts6r0VVH_69BT3OTkLYJKbmgs2y76Ul0BvrcrRKwjCgIk5GUCi3XTAdWCRJjIS8hZDM3nyiynun0jxCNM6C35LhPZlEO0_i-y7Qj11MUTcGEnAAP4HEaWJxjB46AlaRNDJf0HZIpOsHZ9HGQIwlelqhXJiM1tgpHU6zIw1dwLNfnWevd-uX1UP-9Hz_uFo-5ZKzRcxbXumyqDRlwFTLpUauVFFIxBIF1W152zJa60USpmkpOF-gUBpQMVyApnyeXe7_Hbz7GDHEZuNGb9PKpihEVaZD8yJRV3tKeheCR90M3vTpFg2jza6LZlUv36Yu1gm-2MM-yD_uvyv-A5AOjAY</recordid><startdate>20190814</startdate><enddate>20190814</enddate><creator>Li, Yan</creator><creator>Zhang, Shuang-Hong</creator><creator>Chen, Lei</creator><general>Royal Society of Chemistry</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7QF</scope><scope>7QO</scope><scope>7QQ</scope><scope>7SE</scope><scope>7SR</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>FR3</scope><scope>H8G</scope><scope>JG9</scope><scope>L7M</scope><scope>P64</scope><orcidid>https://orcid.org/0000-0003-3012-3135</orcidid><orcidid>https://orcid.org/0000-0003-4738-9765</orcidid></search><sort><creationdate>20190814</creationdate><title>An amino-endcapped octadecylsilane silica-based mixed-mode stationary phase for the simultaneous separation of neutral and ionizable components in fixed-dose combinations</title><author>Li, Yan ; Zhang, Shuang-Hong ; Chen, Lei</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c318t-b37f427f01a1db3cfe3dd22cee4e60fb45b109f85b11f046338e6dfaed1e8af03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Fourier transforms</topic><topic>Hydrochlorothiazide</topic><topic>Infrared analysis</topic><topic>Infrared spectroscopy</topic><topic>Ionic strength</topic><topic>Ions</topic><topic>Magnetic resonance spectroscopy</topic><topic>NMR</topic><topic>NMR spectroscopy</topic><topic>Nuclear magnetic resonance</topic><topic>Packing</topic><topic>Potassium</topic><topic>Selectivity</topic><topic>Separation</topic><topic>Silica</topic><topic>Silicon dioxide</topic><topic>Spectroscopy</topic><topic>Spectrum analysis</topic><topic>Stationary phase</topic><topic>Tablets</topic><topic>Vapor deposition</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Li, Yan</creatorcontrib><creatorcontrib>Zhang, Shuang-Hong</creatorcontrib><creatorcontrib>Chen, Lei</creatorcontrib><collection>CrossRef</collection><collection>Aluminium Industry Abstracts</collection><collection>Biotechnology Research Abstracts</collection><collection>Ceramic Abstracts</collection><collection>Corrosion Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Copper Technical Reference Library</collection><collection>Materials Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Analytical methods</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Li, Yan</au><au>Zhang, Shuang-Hong</au><au>Chen, Lei</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>An amino-endcapped octadecylsilane silica-based mixed-mode stationary phase for the simultaneous separation of neutral and ionizable components in fixed-dose combinations</atitle><jtitle>Analytical methods</jtitle><date>2019-08-14</date><risdate>2019</risdate><volume>11</volume><issue>3</issue><spage>3898</spage><epage>399</epage><pages>3898-399</pages><issn>1759-9660</issn><eissn>1759-9679</eissn><abstract>An amino-endcapped octadecylsilane silica-based stationary phase (ODS-APS) was prepared for simultaneous separation of neutral and ionizable compounds in fixed-dose combinations. The packing was prepared by a three-step vapor deposition method which involves the reaction of silica particles with (3-aminopropyl)trimethoxysilane and octadecyldimethylchlorosilane in an environmentally friendly process. Physicochemical characterization including Fourier transform infrared spectroscopy, solid-state
13
C CP/MAS NMR spectroscopy and elemental analysis confirmed the successful bonding of both octadecyl and amino-endcapped moieties on the ODS-APS phase. The chromatographic performance of the packing was thoroughly evaluated. In addition, the retention mechanism of acidic compounds on the synthesized phase was systematically evaluated by studying the effects of pH and ionic strength of the mobile phase. Finally, two fixed-dose combinations, losartan potassium/hydrochlorothiazide and B-complex vitamin tablets, were analyzed on the ODS-APS phase. The results demonstrated that the ODS-APS packing provides better peak shape and higher selectivity for separating basic and acidic analytes under neutral conditions compared with the traditional ODS phase. The ODS-APS phase also exhibits superior performance for the simultaneous separation of neutral and ionizable drugs in fixed-dose combinations.
An amino-endcapped octadecylsilane silica-based mixed-mode stationary phase (ODS-APS) was prepared by a three-step vapor deposition method for simultaneous separation of neutral and ionizable compounds in fixed-dose combinations.</abstract><cop>Cambridge</cop><pub>Royal Society of Chemistry</pub><doi>10.1039/c9ay00660e</doi><tpages>12</tpages><orcidid>https://orcid.org/0000-0003-3012-3135</orcidid><orcidid>https://orcid.org/0000-0003-4738-9765</orcidid></addata></record> |
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| source | Royal Society Of Chemistry Journals 2008- |
| subjects | Fourier transforms Hydrochlorothiazide Infrared analysis Infrared spectroscopy Ionic strength Ions Magnetic resonance spectroscopy NMR NMR spectroscopy Nuclear magnetic resonance Packing Potassium Selectivity Separation Silica Silicon dioxide Spectroscopy Spectrum analysis Stationary phase Tablets Vapor deposition |
| title | An amino-endcapped octadecylsilane silica-based mixed-mode stationary phase for the simultaneous separation of neutral and ionizable components in fixed-dose combinations |
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