A forebrain undivided: Unleashing model organisms to solve the mysteries of holoprosencephaly

Evolutionary conservation and experimental tractability have made animal model systems invaluable tools in our quest to understand human embryogenesis, both normal and abnormal. Standard genetic approaches, particularly useful in understanding monogenic diseases, are no longer sufficient as research...

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Veröffentlicht in:	Developmental dynamics 2019-08, Vol.248 (8), p.626-633
Hauptverfasser:	Grinblat, Yevgenya, Lipinski, Robert J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal models Animals Cell interactions Embryogenesis Etiology Evolutionary conservation Forebrain Gene-Environment Interaction gene‐environment Hh signaling Holoprosencephaly Holoprosencephaly - etiology Holoprosencephaly - genetics Holoprosencephaly - pathology HPE Humans Mice Models, Animal New technology Pathogenesis Penetrance Prosencephalon - anatomy & histology Prosencephalon - embryology Signal Transduction Wildlife conservation Zic2
Online-Zugang:	Volltext
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