IMSI procedure improves clinical outcomes and embryo morphokinetics in patients with different aetiologies of male infertility
Our objective was to evaluate the effect of IMSI on embryo kinetics and clinical outcomes in patients with different aetiologies of male infertility. A total of 150 couples with different aetiologies of male infertility were randomly divided into ICSI and IMSI treatment groups (n = 75). ICSI was don...
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| Veröffentlicht in: | Andrologia 2019-09, Vol.51 (8), p.e13340-n/a |
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| creator | Mangoli, Esmat Khalili, Mohammad Ali Talebi, Ali Reza Agha‐Rahimi, Azam Soleimani, Mehrdad Faramarzi, Azita Pourentezari, Majid |
| description | Our objective was to evaluate the effect of IMSI on embryo kinetics and clinical outcomes in patients with different aetiologies of male infertility. A total of 150 couples with different aetiologies of male infertility were randomly divided into ICSI and IMSI treatment groups (n = 75). ICSI was done accordingly. For IMSI group, the sperm selection was done using MSOME criteria and then injected. The zygotes were cultured in time‐lapse monitoring system (TLM) for 3 days. A total of 650 embryos were developed and assessed using TLM in two groups. Data showed the rate of fragmentation had significant correlation with different aetiologies (p = 0.01), and the timing of s1, t4, s2 and t5 occurred significantly later in oligoasthenoteratozoospermia (OAT) patients compared with others (p 0.05). The rates of chemical pregnancy and implantation (37.8% and 38.2% respectively) were insignificantly higher in OAT patients compare to others (p > 0.05). Also, the clinical pregnancy and live birth rates (32% and 32% respectively) were insignificantly higher in teratozoospermia (T) cases. Sperm selection with MSOME parameters and IMSI can improve the embryo morphokinetics and clinical outcomes in couples with male factor infertility, especially for OAT and T patients. |
| doi_str_mv | 10.1111/and.13340 |
| format | Article |
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A total of 150 couples with different aetiologies of male infertility were randomly divided into ICSI and IMSI treatment groups (n = 75). ICSI was done accordingly. For IMSI group, the sperm selection was done using MSOME criteria and then injected. The zygotes were cultured in time‐lapse monitoring system (TLM) for 3 days. A total of 650 embryos were developed and assessed using TLM in two groups. Data showed the rate of fragmentation had significant correlation with different aetiologies (p = 0.01), and the timing of s1, t4, s2 and t5 occurred significantly later in oligoasthenoteratozoospermia (OAT) patients compared with others (p < 0.05). In IMSI group, there were no differences in the TLM parameters among different aetiologies (p > 0.05). The rates of chemical pregnancy and implantation (37.8% and 38.2% respectively) were insignificantly higher in OAT patients compare to others (p > 0.05). Also, the clinical pregnancy and live birth rates (32% and 32% respectively) were insignificantly higher in teratozoospermia (T) cases. Sperm selection with MSOME parameters and IMSI can improve the embryo morphokinetics and clinical outcomes in couples with male factor infertility, especially for OAT and T patients.</description><identifier>ISSN: 0303-4569</identifier><identifier>EISSN: 1439-0272</identifier><identifier>DOI: 10.1111/and.13340</identifier><identifier>PMID: 31197867</identifier><language>eng</language><publisher>Germany: Wiley Subscription Services, Inc</publisher><subject>Adult ; Birth Rate ; Clinical outcomes ; Embryo Culture Techniques ; Embryo, Mammalian - diagnostic imaging ; Embryo, Mammalian - embryology ; Embryonic Development ; Embryos ; Etiology ; Female ; Humans ; Implantation ; IMSI ; Infertility ; Infertility, Male - therapy ; Male ; male infertility ; Microinjections ; MSOME ; Oligoasthenoteratozoospermia ; Ovulation Induction - methods ; Patients ; Pregnancy ; Pregnancy Rate ; Semen Analysis - methods ; Sperm ; Sperm Injections, Intracytoplasmic - methods ; time lapse ; Time-Lapse Imaging ; Treatment Outcome ; Zygotes</subject><ispartof>Andrologia, 2019-09, Vol.51 (8), p.e13340-n/a</ispartof><rights>2019 Blackwell Verlag GmbH</rights><rights>2019 Blackwell Verlag GmbH.</rights><rights>Copyright © 2019 Blackwell Verlag GmbH</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3880-200ba8c035ae21f2b779ba3c8067079e54095d5e73fd9265c5f5ac06dcb324c43</citedby><cites>FETCH-LOGICAL-c3880-200ba8c035ae21f2b779ba3c8067079e54095d5e73fd9265c5f5ac06dcb324c43</cites><orcidid>0000-0002-3779-4153 ; 0000-0001-6206-7831</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fand.13340$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fand.13340$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31197867$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mangoli, Esmat</creatorcontrib><creatorcontrib>Khalili, Mohammad Ali</creatorcontrib><creatorcontrib>Talebi, Ali Reza</creatorcontrib><creatorcontrib>Agha‐Rahimi, Azam</creatorcontrib><creatorcontrib>Soleimani, Mehrdad</creatorcontrib><creatorcontrib>Faramarzi, Azita</creatorcontrib><creatorcontrib>Pourentezari, Majid</creatorcontrib><title>IMSI procedure improves clinical outcomes and embryo morphokinetics in patients with different aetiologies of male infertility</title><title>Andrologia</title><addtitle>Andrologia</addtitle><description>Our objective was to evaluate the effect of IMSI on embryo kinetics and clinical outcomes in patients with different aetiologies of male infertility. A total of 150 couples with different aetiologies of male infertility were randomly divided into ICSI and IMSI treatment groups (n = 75). ICSI was done accordingly. For IMSI group, the sperm selection was done using MSOME criteria and then injected. The zygotes were cultured in time‐lapse monitoring system (TLM) for 3 days. A total of 650 embryos were developed and assessed using TLM in two groups. Data showed the rate of fragmentation had significant correlation with different aetiologies (p = 0.01), and the timing of s1, t4, s2 and t5 occurred significantly later in oligoasthenoteratozoospermia (OAT) patients compared with others (p < 0.05). In IMSI group, there were no differences in the TLM parameters among different aetiologies (p > 0.05). The rates of chemical pregnancy and implantation (37.8% and 38.2% respectively) were insignificantly higher in OAT patients compare to others (p > 0.05). Also, the clinical pregnancy and live birth rates (32% and 32% respectively) were insignificantly higher in teratozoospermia (T) cases. Sperm selection with MSOME parameters and IMSI can improve the embryo morphokinetics and clinical outcomes in couples with male factor infertility, especially for OAT and T patients.</description><subject>Adult</subject><subject>Birth Rate</subject><subject>Clinical outcomes</subject><subject>Embryo Culture Techniques</subject><subject>Embryo, Mammalian - diagnostic imaging</subject><subject>Embryo, Mammalian - embryology</subject><subject>Embryonic Development</subject><subject>Embryos</subject><subject>Etiology</subject><subject>Female</subject><subject>Humans</subject><subject>Implantation</subject><subject>IMSI</subject><subject>Infertility</subject><subject>Infertility, Male - therapy</subject><subject>Male</subject><subject>male infertility</subject><subject>Microinjections</subject><subject>MSOME</subject><subject>Oligoasthenoteratozoospermia</subject><subject>Ovulation Induction - methods</subject><subject>Patients</subject><subject>Pregnancy</subject><subject>Pregnancy Rate</subject><subject>Semen Analysis - methods</subject><subject>Sperm</subject><subject>Sperm Injections, Intracytoplasmic - methods</subject><subject>time lapse</subject><subject>Time-Lapse Imaging</subject><subject>Treatment Outcome</subject><subject>Zygotes</subject><issn>0303-4569</issn><issn>1439-0272</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kLtOwzAYRi0EolXpwAsgS0wMaR1f4mSsuFYqMABz5DgOdUniYjtUWXh2DCls_ItvR-eTPwBOYzSLw8xFW85iQig6AOOYkixCmONDMEYEkYiyJBuBqXMbFIYyzik9BiMSxxlPEz4Gn8v7pyXcWiNV2VkFdRP2H8pBWetWS1FD03lpmnATgqBqCtsb2Bi7XZs33SqvpYO6hVvhtWq9gzvt17DUVaVsOEMRCFObVx0EpoKNqENGGx69rrXvT8BRJWqnpvt1Al5urp8v76LV4-3ycrGKJElTFGGECpFKRJhQOK5wwXlWCCJTlHDEM8UoyljJFCdVmeGESVYxIVFSyoJgKimZgPPBG3733inn843pbBsic4wTThJMWRaoi4GS1jhnVZVvrW6E7fMY5d9l56GD_KfswJ7tjV3RqPKP_K02APMB2Ola9f-b8sXD1aD8AiKlikk</recordid><startdate>201909</startdate><enddate>201909</enddate><creator>Mangoli, Esmat</creator><creator>Khalili, Mohammad Ali</creator><creator>Talebi, Ali Reza</creator><creator>Agha‐Rahimi, Azam</creator><creator>Soleimani, Mehrdad</creator><creator>Faramarzi, Azita</creator><creator>Pourentezari, Majid</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TM</scope><scope>K9.</scope><orcidid>https://orcid.org/0000-0002-3779-4153</orcidid><orcidid>https://orcid.org/0000-0001-6206-7831</orcidid></search><sort><creationdate>201909</creationdate><title>IMSI procedure improves clinical outcomes and embryo morphokinetics in patients with different aetiologies of male infertility</title><author>Mangoli, Esmat ; Khalili, Mohammad Ali ; Talebi, Ali Reza ; Agha‐Rahimi, Azam ; Soleimani, Mehrdad ; Faramarzi, Azita ; Pourentezari, Majid</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3880-200ba8c035ae21f2b779ba3c8067079e54095d5e73fd9265c5f5ac06dcb324c43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Adult</topic><topic>Birth Rate</topic><topic>Clinical outcomes</topic><topic>Embryo Culture Techniques</topic><topic>Embryo, Mammalian - diagnostic imaging</topic><topic>Embryo, Mammalian - embryology</topic><topic>Embryonic Development</topic><topic>Embryos</topic><topic>Etiology</topic><topic>Female</topic><topic>Humans</topic><topic>Implantation</topic><topic>IMSI</topic><topic>Infertility</topic><topic>Infertility, Male - therapy</topic><topic>Male</topic><topic>male infertility</topic><topic>Microinjections</topic><topic>MSOME</topic><topic>Oligoasthenoteratozoospermia</topic><topic>Ovulation Induction - methods</topic><topic>Patients</topic><topic>Pregnancy</topic><topic>Pregnancy Rate</topic><topic>Semen Analysis - methods</topic><topic>Sperm</topic><topic>Sperm Injections, Intracytoplasmic - methods</topic><topic>time lapse</topic><topic>Time-Lapse Imaging</topic><topic>Treatment Outcome</topic><topic>Zygotes</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mangoli, Esmat</creatorcontrib><creatorcontrib>Khalili, Mohammad Ali</creatorcontrib><creatorcontrib>Talebi, Ali Reza</creatorcontrib><creatorcontrib>Agha‐Rahimi, Azam</creatorcontrib><creatorcontrib>Soleimani, Mehrdad</creatorcontrib><creatorcontrib>Faramarzi, Azita</creatorcontrib><creatorcontrib>Pourentezari, Majid</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Nucleic Acids Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><jtitle>Andrologia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mangoli, Esmat</au><au>Khalili, Mohammad Ali</au><au>Talebi, Ali Reza</au><au>Agha‐Rahimi, Azam</au><au>Soleimani, Mehrdad</au><au>Faramarzi, Azita</au><au>Pourentezari, Majid</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>IMSI procedure improves clinical outcomes and embryo morphokinetics in patients with different aetiologies of male infertility</atitle><jtitle>Andrologia</jtitle><addtitle>Andrologia</addtitle><date>2019-09</date><risdate>2019</risdate><volume>51</volume><issue>8</issue><spage>e13340</spage><epage>n/a</epage><pages>e13340-n/a</pages><issn>0303-4569</issn><eissn>1439-0272</eissn><abstract>Our objective was to evaluate the effect of IMSI on embryo kinetics and clinical outcomes in patients with different aetiologies of male infertility. A total of 150 couples with different aetiologies of male infertility were randomly divided into ICSI and IMSI treatment groups (n = 75). ICSI was done accordingly. For IMSI group, the sperm selection was done using MSOME criteria and then injected. The zygotes were cultured in time‐lapse monitoring system (TLM) for 3 days. A total of 650 embryos were developed and assessed using TLM in two groups. Data showed the rate of fragmentation had significant correlation with different aetiologies (p = 0.01), and the timing of s1, t4, s2 and t5 occurred significantly later in oligoasthenoteratozoospermia (OAT) patients compared with others (p < 0.05). In IMSI group, there were no differences in the TLM parameters among different aetiologies (p > 0.05). The rates of chemical pregnancy and implantation (37.8% and 38.2% respectively) were insignificantly higher in OAT patients compare to others (p > 0.05). Also, the clinical pregnancy and live birth rates (32% and 32% respectively) were insignificantly higher in teratozoospermia (T) cases. Sperm selection with MSOME parameters and IMSI can improve the embryo morphokinetics and clinical outcomes in couples with male factor infertility, especially for OAT and T patients.</abstract><cop>Germany</cop><pub>Wiley Subscription Services, Inc</pub><pmid>31197867</pmid><doi>10.1111/and.13340</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0002-3779-4153</orcidid><orcidid>https://orcid.org/0000-0001-6206-7831</orcidid><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0303-4569 |
| ispartof | Andrologia, 2019-09, Vol.51 (8), p.e13340-n/a |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Adult Birth Rate Clinical outcomes Embryo Culture Techniques Embryo, Mammalian - diagnostic imaging Embryo, Mammalian - embryology Embryonic Development Embryos Etiology Female Humans Implantation IMSI Infertility Infertility, Male - therapy Male male infertility Microinjections MSOME Oligoasthenoteratozoospermia Ovulation Induction - methods Patients Pregnancy Pregnancy Rate Semen Analysis - methods Sperm Sperm Injections, Intracytoplasmic - methods time lapse Time-Lapse Imaging Treatment Outcome Zygotes |
| title | IMSI procedure improves clinical outcomes and embryo morphokinetics in patients with different aetiologies of male infertility |
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