Therapeutic efficacy evaluation of radioimmunotherapy with 90 Y-labeled anti-podoplanin antibody NZ-12 for mesothelioma

Podoplanin is a type I transmembrane sialomucin-like glycoprotein that is highly expressed in malignant mesothelioma. The rat-human chimeric antibody NZ-12 has high affinity for human podoplanin and antibody-dependent cellular cytotoxicity and is applicable for radioimmunotherapy (RIT) to enhance th...

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Veröffentlicht in:	Cancer science 2019-05, Vol.110 (5), p.1653-1664
Hauptverfasser:	Sudo, Hitomi, Tsuji, Atsushi B, Sugyo, Aya, Saga, Tsuneo, Kaneko, Mika K, Kato, Yukinari, Higashi, Tatsuya
Format:	Artikel
Sprache:	eng
Schlagworte:	Affinity Animals Antibodies, Monoclonal - administration & dosage Antibodies, Monoclonal - chemistry Antibodies, Monoclonal - pharmacokinetics Antibody-Dependent Cell Cytotoxicity Antigens Antitumor activity Body weight Body weight loss Brain cancer Cancer therapies Cell Line, Tumor Cellulose acetate Chemotherapy Cytotoxicity Dosimetry Gene Expression Regulation, Neoplastic Humans Immunoglobulins Indium Radioisotopes - chemistry Laboratory animals Lung cancer Lung Neoplasms - diagnostic imaging Lung Neoplasms - metabolism Lung Neoplasms - radiotherapy Male Medical prognosis Membrane Glycoproteins - metabolism Mesothelioma Mesothelioma - diagnostic imaging Mesothelioma - metabolism Mesothelioma - radiotherapy Mesothelioma, Malignant Metastasis Mice Mice, Nude Patients Radiation therapy Radioimmunotherapy - methods Rats Studies Treatment Outcome Tumors Up-Regulation Xenograft Model Antitumor Assays Xenografts Yttrium Radioisotopes - chemistry
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