GATA 2 hypomorphism induces chronic myelomonocytic leukemia in mice

The transcription factor GATA 2 regulates normal hematopoiesis, particularly in‐ stem cell maintenance and myeloid differentiation. Various heteroallelic GATA 2 gene mutations are associated with a variety of hematological neoplasms, including myelodysplastic syndromes and leukemias. Here, we report...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Cancer science 2019-04, Vol.110 (4), p.1183-1193
Hauptverfasser:	Harada, Nobuhiko, Hasegawa, Atsushi, Hirano, Ikuo, Yamamoto, Masayuki, Shimizu, Ritsuko
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Cell differentiation Cell proliferation Chronic myelomonocytic leukemia Cytokine receptors Drug dosages Dysplasia Embryos Flow cytometry Gene expression Genetic transformation Geriatrics Granulocytes Hematology Hemopoiesis Lethality Leukemia Leukocytes (granulocytic) Leukocytosis Life sciences Lipopolysaccharides Macrophages Monocytes Mutation Myelodysplastic syndrome Myelomonocytic leukemia R&D Research & development Rodents Software Stem cell transplantation Stem cells Thrombocytopenia Tumors
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!