Crystallization of Cephradine Polymorphs and Hydrates from Mixed Solvents of Methanol and Water
Cephradine monohydrate (CPH) crystallizes with a needle‐like shape which leads to severe agglomeration and slow filtration. Effects of different operating conditions on the particle size and shape as well as the filterability of the crystal products are described. The solubility and stability of one...
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| Veröffentlicht in: | Chemical engineering & technology 2019-07, Vol.42 (7), p.1512-1518 |
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| creator | Ostergaard, Iben Lopez de Diego, Heidi Qu, Haiyan |
| description | Cephradine monohydrate (CPH) crystallizes with a needle‐like shape which leads to severe agglomeration and slow filtration. Effects of different operating conditions on the particle size and shape as well as the filterability of the crystal products are described. The solubility and stability of one anhydrate of cephradine (CPA1) and CPH as a function of temperature and water activity was investigated in different methanol and water mixtures. A solvent‐mediated transformation from CPH to CPA1 was observed at water mole fractions below 0.2–0.35 depending on the temperature. The crystallization behavior of CPH was studied by linear cooling and antisolvent crystallization. Lowering the cooling rate and addition of seeds led to an increase in particle size and improvement of filterability.
The solubility and relative stability of cephradine anhydrate and monohydrate in various water‐methanol mixtures were evaluated at different temperatures. Cephradine monohydrate was crystallized by cooling crystallization from aqueous solutions. It was found that using a slow cooling rate and seeding can improve the particulate properties as well as the filterability of the obtained products. |
| doi_str_mv | 10.1002/ceat.201800689 |
| format | Article |
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The solubility and relative stability of cephradine anhydrate and monohydrate in various water‐methanol mixtures were evaluated at different temperatures. Cephradine monohydrate was crystallized by cooling crystallization from aqueous solutions. It was found that using a slow cooling rate and seeding can improve the particulate properties as well as the filterability of the obtained products.</description><identifier>ISSN: 0930-7516</identifier><identifier>EISSN: 1521-4125</identifier><identifier>DOI: 10.1002/ceat.201800689</identifier><language>eng</language><publisher>Frankfurt: Wiley Subscription Services, Inc</publisher><subject>Anhydrate/hydrate ; Cephradine ; Cooling rate ; Crystallization ; Filterability ; Hydrates ; Methanol ; Particle size ; Particulate properties ; Solubility ; Solvents ; Water activity</subject><ispartof>Chemical engineering & technology, 2019-07, Vol.42 (7), p.1512-1518</ispartof><rights>2019 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3949-527ccc3afff7aa0eeb43b745fc54ceb1be6711081f077498f56f6cefabccebb13</citedby><cites>FETCH-LOGICAL-c3949-527ccc3afff7aa0eeb43b745fc54ceb1be6711081f077498f56f6cefabccebb13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fceat.201800689$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fceat.201800689$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>315,781,785,1418,27926,27927,45576,45577</link.rule.ids></links><search><creatorcontrib>Ostergaard, Iben</creatorcontrib><creatorcontrib>Lopez de Diego, Heidi</creatorcontrib><creatorcontrib>Qu, Haiyan</creatorcontrib><title>Crystallization of Cephradine Polymorphs and Hydrates from Mixed Solvents of Methanol and Water</title><title>Chemical engineering & technology</title><description>Cephradine monohydrate (CPH) crystallizes with a needle‐like shape which leads to severe agglomeration and slow filtration. Effects of different operating conditions on the particle size and shape as well as the filterability of the crystal products are described. The solubility and stability of one anhydrate of cephradine (CPA1) and CPH as a function of temperature and water activity was investigated in different methanol and water mixtures. A solvent‐mediated transformation from CPH to CPA1 was observed at water mole fractions below 0.2–0.35 depending on the temperature. The crystallization behavior of CPH was studied by linear cooling and antisolvent crystallization. Lowering the cooling rate and addition of seeds led to an increase in particle size and improvement of filterability.
The solubility and relative stability of cephradine anhydrate and monohydrate in various water‐methanol mixtures were evaluated at different temperatures. Cephradine monohydrate was crystallized by cooling crystallization from aqueous solutions. It was found that using a slow cooling rate and seeding can improve the particulate properties as well as the filterability of the obtained products.</description><subject>Anhydrate/hydrate</subject><subject>Cephradine</subject><subject>Cooling rate</subject><subject>Crystallization</subject><subject>Filterability</subject><subject>Hydrates</subject><subject>Methanol</subject><subject>Particle size</subject><subject>Particulate properties</subject><subject>Solubility</subject><subject>Solvents</subject><subject>Water activity</subject><issn>0930-7516</issn><issn>1521-4125</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNqFkNFKwzAUhoMoOKe3Xge8bk3aJmkvR5lO2FBw4mVM0xPW0TU16dT6ND6LT2bnRC-9Ovyc7zsHfoTOKQkpIdGlBtWFEaEpITzNDtCIsogGCY3YIRqRLCaBYJQfoxPv14QQOoQRespd7ztV19W76irbYGtwDu3KqbJqAN_Zut9Y1648Vk2JZ33pVAceG2c3eFG9QYnvbf0CTecH8_NjAd1KNbb-ph8H1J2iI6NqD2c_c4werqbLfBbMb69v8sk80HGWZAGLhNY6VsYYoRQBKJK4EAkzmiUaCloAF5SSlBoiRJKlhnHDNRhV6GFd0HiMLvZ3W2eft-A7ubZb1wwvZRRxxrhgPB2ocE9pZ713YGTrqo1yvaRE7lqUuxblb4uDkO2F16qG_h9a5tPJ8s_9AmmaeYo</recordid><startdate>201907</startdate><enddate>201907</enddate><creator>Ostergaard, Iben</creator><creator>Lopez de Diego, Heidi</creator><creator>Qu, Haiyan</creator><general>Wiley Subscription Services, Inc</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7U5</scope><scope>8FD</scope><scope>L7M</scope></search><sort><creationdate>201907</creationdate><title>Crystallization of Cephradine Polymorphs and Hydrates from Mixed Solvents of Methanol and Water</title><author>Ostergaard, Iben ; Lopez de Diego, Heidi ; Qu, Haiyan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3949-527ccc3afff7aa0eeb43b745fc54ceb1be6711081f077498f56f6cefabccebb13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Anhydrate/hydrate</topic><topic>Cephradine</topic><topic>Cooling rate</topic><topic>Crystallization</topic><topic>Filterability</topic><topic>Hydrates</topic><topic>Methanol</topic><topic>Particle size</topic><topic>Particulate properties</topic><topic>Solubility</topic><topic>Solvents</topic><topic>Water activity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ostergaard, Iben</creatorcontrib><creatorcontrib>Lopez de Diego, Heidi</creatorcontrib><creatorcontrib>Qu, Haiyan</creatorcontrib><collection>CrossRef</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Technology Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><jtitle>Chemical engineering & technology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ostergaard, Iben</au><au>Lopez de Diego, Heidi</au><au>Qu, Haiyan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Crystallization of Cephradine Polymorphs and Hydrates from Mixed Solvents of Methanol and Water</atitle><jtitle>Chemical engineering & technology</jtitle><date>2019-07</date><risdate>2019</risdate><volume>42</volume><issue>7</issue><spage>1512</spage><epage>1518</epage><pages>1512-1518</pages><issn>0930-7516</issn><eissn>1521-4125</eissn><abstract>Cephradine monohydrate (CPH) crystallizes with a needle‐like shape which leads to severe agglomeration and slow filtration. Effects of different operating conditions on the particle size and shape as well as the filterability of the crystal products are described. The solubility and stability of one anhydrate of cephradine (CPA1) and CPH as a function of temperature and water activity was investigated in different methanol and water mixtures. A solvent‐mediated transformation from CPH to CPA1 was observed at water mole fractions below 0.2–0.35 depending on the temperature. The crystallization behavior of CPH was studied by linear cooling and antisolvent crystallization. Lowering the cooling rate and addition of seeds led to an increase in particle size and improvement of filterability.
The solubility and relative stability of cephradine anhydrate and monohydrate in various water‐methanol mixtures were evaluated at different temperatures. Cephradine monohydrate was crystallized by cooling crystallization from aqueous solutions. It was found that using a slow cooling rate and seeding can improve the particulate properties as well as the filterability of the obtained products.</abstract><cop>Frankfurt</cop><pub>Wiley Subscription Services, Inc</pub><doi>10.1002/ceat.201800689</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Anhydrate/hydrate Cephradine Cooling rate Crystallization Filterability Hydrates Methanol Particle size Particulate properties Solubility Solvents Water activity |
| title | Crystallization of Cephradine Polymorphs and Hydrates from Mixed Solvents of Methanol and Water |
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