Osteogenic transdifferentiation of vascular smooth muscle cells isolated from spontaneously hypertensive rats and potential menaquinone‐4 inhibiting effect

Vascular calcification (VC) is an active and cell‐mediated process that shares many common features with osteogenesis. Knowledge demonstrates that in the presence of risk factors, such as hypertension, vascular smooth muscle cells (vSMCs) lose their contractile phenotype and transdifferentiate into...

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Veröffentlicht in:	Journal of cellular physiology 2019-11, Vol.234 (11), p.19761-19773
Hauptverfasser:	Mandatori, Domitilla, Pipino, Caterina, Di Tomo, Pamela, Schiavone, Valeria, Ranieri, Antonia, Pantalone, Sara, Di Silvestre, Sara, Di Pietrantonio, Nadia, Ucci, Mariangela, Palmerini, Carola, Failli, Paola, Di Pietro, Natalia, Pandolfi, Assunta
Format:	Artikel
Sprache:	eng
Schlagworte:	Arteriosclerosis Atherosclerosis Biocompatibility Biomedical materials Calcification Calcification (ectopic) Dietary supplements Genotype & phenotype Hypertension Menaquinones menaquinone‐4/Vitamin K2 Muscle contraction Muscles Natural & organic foods Osteoblasts Osteogenesis Phenotypes Risk analysis Risk factors Rodents Smooth muscle transdifferentiation vascular smooth muscle cells
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