ATXN10 Microsatellite Distribution in a Peruvian Amerindian Population
Spinocerebellar ataxia type 10 (SCA10) is a repeat expansion disease occurring mostly in Latin America, suggesting that the mutation spread with the peopling of the Americas, or that Amerindian populations, have a higher ATXN10 mutability. High frequency of large normal alleles is associated with pr...
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| Veröffentlicht in: | Cerebellum (London, England) England), 2019-10, Vol.18 (5), p.841-848 |
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| creator | Véliz-Otani, Diego Inca-Martinez, Miguel Bampi, Giovana B. Ortega, Olimpio Jardim, Laura B. Saraiva-Pereira, Maria Luiza Mazzetti, Pilar Cornejo-Olivas, Mario |
| description | Spinocerebellar ataxia type 10 (SCA10) is a repeat expansion disease occurring mostly in Latin America, suggesting that the mutation spread with the peopling of the Americas, or that Amerindian populations, have a higher
ATXN10
mutability. High frequency of large normal alleles is associated with prevalence and relative frequency of other repeat expansion diseases. To test whether the allele distribution of the SCA10-causing
ATXN10
microsatellite in an Amerindian Peruvian population differs from that of other populations. The
ATXN10
allele distribution in a Quechua Peruvian population from Puno, Peru, is similar to that of Finland. Mean allele size and mode were also similar to those of Mexico, Japan, and white Europeans.
ATXN10
allele distribution in a healthy Amerindian population from Peru does not differ from that of other populations. |
| doi_str_mv | 10.1007/s12311-019-01057-x |
| format | Article |
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ATXN10
mutability. High frequency of large normal alleles is associated with prevalence and relative frequency of other repeat expansion diseases. To test whether the allele distribution of the SCA10-causing
ATXN10
microsatellite in an Amerindian Peruvian population differs from that of other populations. The
ATXN10
allele distribution in a Quechua Peruvian population from Puno, Peru, is similar to that of Finland. Mean allele size and mode were also similar to those of Mexico, Japan, and white Europeans.
ATXN10
allele distribution in a healthy Amerindian population from Peru does not differ from that of other populations.</description><identifier>ISSN: 1473-4222</identifier><identifier>EISSN: 1473-4230</identifier><identifier>DOI: 10.1007/s12311-019-01057-x</identifier><identifier>PMID: 31342269</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Alleles ; Ataxin-10 - genetics ; Biomedical and Life Sciences ; Biomedicine ; DNA Repeat Expansion - genetics ; Europe - epidemiology ; Humans ; Japan - epidemiology ; Mexico - epidemiology ; Microsatellite Repeats - genetics ; Neurobiology ; Neurology ; Neurosciences ; Original Paper ; Peru - epidemiology ; Population ; Population genetics ; Population Surveillance - methods ; Spinocerebellar Ataxias - diagnosis ; Spinocerebellar Ataxias - epidemiology ; Spinocerebellar Ataxias - genetics</subject><ispartof>Cerebellum (London, England), 2019-10, Vol.18 (5), p.841-848</ispartof><rights>Springer Science+Business Media, LLC, part of Springer Nature 2019</rights><rights>The Cerebellum is a copyright of Springer, (2019). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-5b163098c1eb7b02f3f41f66a7928c1654d06d7669962ba33ebcec243e4aaba3</citedby><cites>FETCH-LOGICAL-c375t-5b163098c1eb7b02f3f41f66a7928c1654d06d7669962ba33ebcec243e4aaba3</cites><orcidid>0000-0001-5507-6457</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12311-019-01057-x$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s12311-019-01057-x$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31342269$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Véliz-Otani, Diego</creatorcontrib><creatorcontrib>Inca-Martinez, Miguel</creatorcontrib><creatorcontrib>Bampi, Giovana B.</creatorcontrib><creatorcontrib>Ortega, Olimpio</creatorcontrib><creatorcontrib>Jardim, Laura B.</creatorcontrib><creatorcontrib>Saraiva-Pereira, Maria Luiza</creatorcontrib><creatorcontrib>Mazzetti, Pilar</creatorcontrib><creatorcontrib>Cornejo-Olivas, Mario</creatorcontrib><title>ATXN10 Microsatellite Distribution in a Peruvian Amerindian Population</title><title>Cerebellum (London, England)</title><addtitle>Cerebellum</addtitle><addtitle>Cerebellum</addtitle><description>Spinocerebellar ataxia type 10 (SCA10) is a repeat expansion disease occurring mostly in Latin America, suggesting that the mutation spread with the peopling of the Americas, or that Amerindian populations, have a higher
ATXN10
mutability. High frequency of large normal alleles is associated with prevalence and relative frequency of other repeat expansion diseases. To test whether the allele distribution of the SCA10-causing
ATXN10
microsatellite in an Amerindian Peruvian population differs from that of other populations. The
ATXN10
allele distribution in a Quechua Peruvian population from Puno, Peru, is similar to that of Finland. Mean allele size and mode were also similar to those of Mexico, Japan, and white Europeans.
ATXN10
allele distribution in a healthy Amerindian population from Peru does not differ from that of other populations.</description><subject>Alleles</subject><subject>Ataxin-10 - genetics</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>DNA Repeat Expansion - genetics</subject><subject>Europe - epidemiology</subject><subject>Humans</subject><subject>Japan - epidemiology</subject><subject>Mexico - epidemiology</subject><subject>Microsatellite Repeats - genetics</subject><subject>Neurobiology</subject><subject>Neurology</subject><subject>Neurosciences</subject><subject>Original Paper</subject><subject>Peru - epidemiology</subject><subject>Population</subject><subject>Population genetics</subject><subject>Population Surveillance - methods</subject><subject>Spinocerebellar Ataxias - diagnosis</subject><subject>Spinocerebellar Ataxias - epidemiology</subject><subject>Spinocerebellar Ataxias - genetics</subject><issn>1473-4222</issn><issn>1473-4230</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp9kMFOwzAMhiMEYjB4AQ6oEueCnbQJOU6DAdKAHXbgFqVtijJ17UhaNN6elI5x42DFsT__ln9CLhCuEUDceKQMMQaUISAV8faAnGAiWJxQBof7nNIROfV-BUApJOKYjBiyUObyhMwmy7cXhOjZ5q7xujVVZVsT3VnfOpt1rW3qyNaRjhbGdZ9W19FkbZytiz5dNJuu0j1zRo5KXXlzvnvHZDm7X04f4_nrw9N0Mo9zJtI2TjPkDORtjiYTGdCSlQmWnGshaSjyNCmAF4JzKTnNNGMmy01OE2YSrcN_TK4G2Y1rPjrjW7VqOleHjSqcw4CiBAwUHaj-JO9MqTbOrrX7Ugiqd04NzqngnPpxTm3D0OVOusvWptiP_FoVADYAPrTqd-P-dv8j-w2gpniV</recordid><startdate>20191001</startdate><enddate>20191001</enddate><creator>Véliz-Otani, Diego</creator><creator>Inca-Martinez, Miguel</creator><creator>Bampi, Giovana B.</creator><creator>Ortega, Olimpio</creator><creator>Jardim, Laura B.</creator><creator>Saraiva-Pereira, Maria Luiza</creator><creator>Mazzetti, Pilar</creator><creator>Cornejo-Olivas, Mario</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><orcidid>https://orcid.org/0000-0001-5507-6457</orcidid></search><sort><creationdate>20191001</creationdate><title>ATXN10 Microsatellite Distribution in a Peruvian Amerindian Population</title><author>Véliz-Otani, Diego ; Inca-Martinez, Miguel ; Bampi, Giovana B. ; Ortega, Olimpio ; Jardim, Laura B. ; Saraiva-Pereira, Maria Luiza ; Mazzetti, Pilar ; Cornejo-Olivas, Mario</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c375t-5b163098c1eb7b02f3f41f66a7928c1654d06d7669962ba33ebcec243e4aaba3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Alleles</topic><topic>Ataxin-10 - genetics</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>DNA Repeat Expansion - genetics</topic><topic>Europe - epidemiology</topic><topic>Humans</topic><topic>Japan - epidemiology</topic><topic>Mexico - epidemiology</topic><topic>Microsatellite Repeats - genetics</topic><topic>Neurobiology</topic><topic>Neurology</topic><topic>Neurosciences</topic><topic>Original Paper</topic><topic>Peru - epidemiology</topic><topic>Population</topic><topic>Population genetics</topic><topic>Population Surveillance - methods</topic><topic>Spinocerebellar Ataxias - diagnosis</topic><topic>Spinocerebellar Ataxias - epidemiology</topic><topic>Spinocerebellar Ataxias - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Véliz-Otani, Diego</creatorcontrib><creatorcontrib>Inca-Martinez, Miguel</creatorcontrib><creatorcontrib>Bampi, Giovana B.</creatorcontrib><creatorcontrib>Ortega, Olimpio</creatorcontrib><creatorcontrib>Jardim, Laura B.</creatorcontrib><creatorcontrib>Saraiva-Pereira, Maria Luiza</creatorcontrib><creatorcontrib>Mazzetti, Pilar</creatorcontrib><creatorcontrib>Cornejo-Olivas, Mario</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest Psychology</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><jtitle>Cerebellum (London, England)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Véliz-Otani, Diego</au><au>Inca-Martinez, Miguel</au><au>Bampi, Giovana B.</au><au>Ortega, Olimpio</au><au>Jardim, Laura B.</au><au>Saraiva-Pereira, Maria Luiza</au><au>Mazzetti, Pilar</au><au>Cornejo-Olivas, Mario</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>ATXN10 Microsatellite Distribution in a Peruvian Amerindian Population</atitle><jtitle>Cerebellum (London, England)</jtitle><stitle>Cerebellum</stitle><addtitle>Cerebellum</addtitle><date>2019-10-01</date><risdate>2019</risdate><volume>18</volume><issue>5</issue><spage>841</spage><epage>848</epage><pages>841-848</pages><issn>1473-4222</issn><eissn>1473-4230</eissn><abstract>Spinocerebellar ataxia type 10 (SCA10) is a repeat expansion disease occurring mostly in Latin America, suggesting that the mutation spread with the peopling of the Americas, or that Amerindian populations, have a higher
ATXN10
mutability. High frequency of large normal alleles is associated with prevalence and relative frequency of other repeat expansion diseases. To test whether the allele distribution of the SCA10-causing
ATXN10
microsatellite in an Amerindian Peruvian population differs from that of other populations. The
ATXN10
allele distribution in a Quechua Peruvian population from Puno, Peru, is similar to that of Finland. Mean allele size and mode were also similar to those of Mexico, Japan, and white Europeans.
ATXN10
allele distribution in a healthy Amerindian population from Peru does not differ from that of other populations.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>31342269</pmid><doi>10.1007/s12311-019-01057-x</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0001-5507-6457</orcidid></addata></record> |
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| subjects | Alleles Ataxin-10 - genetics Biomedical and Life Sciences Biomedicine DNA Repeat Expansion - genetics Europe - epidemiology Humans Japan - epidemiology Mexico - epidemiology Microsatellite Repeats - genetics Neurobiology Neurology Neurosciences Original Paper Peru - epidemiology Population Population genetics Population Surveillance - methods Spinocerebellar Ataxias - diagnosis Spinocerebellar Ataxias - epidemiology Spinocerebellar Ataxias - genetics |
| title | ATXN10 Microsatellite Distribution in a Peruvian Amerindian Population |
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