Evaluatıon of hypofractıonated stereotactıc radıotherapy (HFSRT) to the resectıon cavıty after surgıcal resectıon of braın metastases: A sıngle center experıence
INTRODUCTON: Adjuvant radiotherapy after surgical resection is used for the treatment of patients with brain metastasis. In this study, we assessed the use of adjuvant hypofractionated stereotactic radiotherapy (HFSRT) to the resection cavity for the management of patients with brain metastasis. MAT...
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| Veröffentlicht in: | Indian journal of cancer 2019-07, Vol.56 (3), p.202-206 |
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| container_title | Indian journal of cancer |
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| creator | Dincoglan, Ferrat Sager, Omer Uysal, Bora Demiral, Selcuk Gamsiz, Hakan Gündem, Esin Elcim, Yelda Dirican, Bahar Beyzadeoglu, Murat |
| description | INTRODUCTON: Adjuvant radiotherapy after surgical resection is used for the treatment of patients with brain metastasis. In this study, we assessed the use of adjuvant hypofractionated stereotactic radiotherapy (HFSRT) to the resection cavity for the management of patients with brain metastasis.
MATERIALS AND METHODS: A total of 28 patients undergoing surgical resection for their brain metastasis were treated using HFSRT to the resection cavity. A total HFSRT dose of 25-30 Gray (Gy) was delivered in 5 consecutive daily fractions. Patients were retrospectively assessed for toxicity, local control, and survival outcomes. Kaplan-Meier method and log-rank test were used for statistical analysis.
RESULTS: Median planning target volume (PTV) was 27.2 cc (range: 6-76.1 cc). At a median follow-up time of 11 months (range: 2-21 months.), 1-year local control rate was 85.7%, and 1-year distant failure rate was 57.1% (16 patients). Median overall survival was 15 months from HFSRT. Higher recursive partitioning analysis class (P = 0.01) and the presence of extracranial metastases (P = 0.02) were associated with decreased overall survival on statistical analysis. There was no radiation necrosis observed during follow-up.
CONCLUSION: HFSRT to the resection cavity offers a safe and effective adjuvant treatment for patients undergoing surgical resection of brain metastasis. With comparable local control rates, HFSRT may serve as a viable alternative to whole brain irradiation. |
| doi_str_mv | 10.4103/ijc.IJC_345_18 |
| format | Article |
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MATERIALS AND METHODS: A total of 28 patients undergoing surgical resection for their brain metastasis were treated using HFSRT to the resection cavity. A total HFSRT dose of 25-30 Gray (Gy) was delivered in 5 consecutive daily fractions. Patients were retrospectively assessed for toxicity, local control, and survival outcomes. Kaplan-Meier method and log-rank test were used for statistical analysis.
RESULTS: Median planning target volume (PTV) was 27.2 cc (range: 6-76.1 cc). At a median follow-up time of 11 months (range: 2-21 months.), 1-year local control rate was 85.7%, and 1-year distant failure rate was 57.1% (16 patients). Median overall survival was 15 months from HFSRT. Higher recursive partitioning analysis class (P = 0.01) and the presence of extracranial metastases (P = 0.02) were associated with decreased overall survival on statistical analysis. There was no radiation necrosis observed during follow-up.
CONCLUSION: HFSRT to the resection cavity offers a safe and effective adjuvant treatment for patients undergoing surgical resection of brain metastasis. With comparable local control rates, HFSRT may serve as a viable alternative to whole brain irradiation.</description><identifier>ISSN: 0019-509X</identifier><identifier>EISSN: 1998-4774</identifier><identifier>DOI: 10.4103/ijc.IJC_345_18</identifier><language>eng</language><publisher>Mumbai: Wolters Kluwer India Pvt. Ltd</publisher><subject>Brain cancer ; Cancer ; Medical imaging ; Metastasis ; Multivariate analysis ; Patients ; Studies ; Surgery ; Toxicity ; Work stations</subject><ispartof>Indian journal of cancer, 2019-07, Vol.56 (3), p.202-206</ispartof><rights>2019. This work is published under https://creativecommons.org/licenses/by-nc-sa/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c271t-10de4671a5ad8268c99ea487ead56c98cb6c3a6d9c849e00cf7cf145c89a535d3</citedby><cites>FETCH-LOGICAL-c271t-10de4671a5ad8268c99ea487ead56c98cb6c3a6d9c849e00cf7cf145c89a535d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,27463,27929,27930</link.rule.ids></links><search><creatorcontrib>Dincoglan, Ferrat</creatorcontrib><creatorcontrib>Sager, Omer</creatorcontrib><creatorcontrib>Uysal, Bora</creatorcontrib><creatorcontrib>Demiral, Selcuk</creatorcontrib><creatorcontrib>Gamsiz, Hakan</creatorcontrib><creatorcontrib>Gündem, Esin</creatorcontrib><creatorcontrib>Elcim, Yelda</creatorcontrib><creatorcontrib>Dirican, Bahar</creatorcontrib><creatorcontrib>Beyzadeoglu, Murat</creatorcontrib><title>Evaluatıon of hypofractıonated stereotactıc radıotherapy (HFSRT) to the resectıon cavıty after surgıcal resectıon of braın metastases: A sıngle center experıence</title><title>Indian journal of cancer</title><description>INTRODUCTON: Adjuvant radiotherapy after surgical resection is used for the treatment of patients with brain metastasis. In this study, we assessed the use of adjuvant hypofractionated stereotactic radiotherapy (HFSRT) to the resection cavity for the management of patients with brain metastasis.
MATERIALS AND METHODS: A total of 28 patients undergoing surgical resection for their brain metastasis were treated using HFSRT to the resection cavity. A total HFSRT dose of 25-30 Gray (Gy) was delivered in 5 consecutive daily fractions. Patients were retrospectively assessed for toxicity, local control, and survival outcomes. Kaplan-Meier method and log-rank test were used for statistical analysis.
RESULTS: Median planning target volume (PTV) was 27.2 cc (range: 6-76.1 cc). At a median follow-up time of 11 months (range: 2-21 months.), 1-year local control rate was 85.7%, and 1-year distant failure rate was 57.1% (16 patients). Median overall survival was 15 months from HFSRT. Higher recursive partitioning analysis class (P = 0.01) and the presence of extracranial metastases (P = 0.02) were associated with decreased overall survival on statistical analysis. There was no radiation necrosis observed during follow-up.
CONCLUSION: HFSRT to the resection cavity offers a safe and effective adjuvant treatment for patients undergoing surgical resection of brain metastasis. With comparable local control rates, HFSRT may serve as a viable alternative to whole brain irradiation.</description><subject>Brain cancer</subject><subject>Cancer</subject><subject>Medical imaging</subject><subject>Metastasis</subject><subject>Multivariate analysis</subject><subject>Patients</subject><subject>Studies</subject><subject>Surgery</subject><subject>Toxicity</subject><subject>Work stations</subject><issn>0019-509X</issn><issn>1998-4774</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp1kc9KHEEQxhtJwI3JNeeGXMxh1v43M925iCwaFSGgBnJryp4adZ2dHrt73Ow75bLvsA-W1hXMJVBQ8NX3q6L4CPnM2VRxJg_u5256dj6zUpWW6x0y4cboQtW1ekcmjHFTlMz82iUfYpwzJqRQekL-HD9BN0LarH1PfUvvVoNvA7gXARI2NCYM6NOL5GiAJk_SHQYYVnT_9OTq8vorTZ5miQaMuCWpg6fNOq0otBmncQy3mYbuX0u-dhNgs-7pAhPEXBi_0SMas3TbIXXYP7P4e8CwWWPv8CN530IX8dNr3yM_T46vZ6fFxY_vZ7Oji8KJmqeCswZVVXMoodGi0s4YBKVrhKasnNHupnISqsY4rQwy5tratVyVThsoZdnIPfJlu3cI_nHEmOzcj6HPJ60QlahqKY3IrunW5YKPMWBrh3C_gLCynNnnRGxOxL4lkoHDLbD0Xf4sPnTjEoNdYPPQ--V_KCuYsK8hyb_Z0qGp</recordid><startdate>20190701</startdate><enddate>20190701</enddate><creator>Dincoglan, Ferrat</creator><creator>Sager, Omer</creator><creator>Uysal, Bora</creator><creator>Demiral, Selcuk</creator><creator>Gamsiz, Hakan</creator><creator>Gündem, Esin</creator><creator>Elcim, Yelda</creator><creator>Dirican, Bahar</creator><creator>Beyzadeoglu, Murat</creator><general>Wolters Kluwer India Pvt. 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In this study, we assessed the use of adjuvant hypofractionated stereotactic radiotherapy (HFSRT) to the resection cavity for the management of patients with brain metastasis.
MATERIALS AND METHODS: A total of 28 patients undergoing surgical resection for their brain metastasis were treated using HFSRT to the resection cavity. A total HFSRT dose of 25-30 Gray (Gy) was delivered in 5 consecutive daily fractions. Patients were retrospectively assessed for toxicity, local control, and survival outcomes. Kaplan-Meier method and log-rank test were used for statistical analysis.
RESULTS: Median planning target volume (PTV) was 27.2 cc (range: 6-76.1 cc). At a median follow-up time of 11 months (range: 2-21 months.), 1-year local control rate was 85.7%, and 1-year distant failure rate was 57.1% (16 patients). Median overall survival was 15 months from HFSRT. Higher recursive partitioning analysis class (P = 0.01) and the presence of extracranial metastases (P = 0.02) were associated with decreased overall survival on statistical analysis. There was no radiation necrosis observed during follow-up.
CONCLUSION: HFSRT to the resection cavity offers a safe and effective adjuvant treatment for patients undergoing surgical resection of brain metastasis. With comparable local control rates, HFSRT may serve as a viable alternative to whole brain irradiation.</abstract><cop>Mumbai</cop><pub>Wolters Kluwer India Pvt. Ltd</pub><doi>10.4103/ijc.IJC_345_18</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0019-509X |
| ispartof | Indian journal of cancer, 2019-07, Vol.56 (3), p.202-206 |
| issn | 0019-509X 1998-4774 |
| language | eng |
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| source | Medknow Open Access Medical Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Bioline International |
| subjects | Brain cancer Cancer Medical imaging Metastasis Multivariate analysis Patients Studies Surgery Toxicity Work stations |
| title | Evaluatıon of hypofractıonated stereotactıc radıotherapy (HFSRT) to the resectıon cavıty after surgıcal resectıon of braın metastases: A sıngle center experıence |
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