GnRH analogs do not protect ovaries from chemotherapy-induced ultrastructural injury in Hodgkin’s lymphoma patients
Purpose To determine the protective effect of gonadotropin-releasing hormone analogs (GnRHa) using several ultrasound and endocrine markers to detect ultrastructural ovarian damage in Hodgkin’s lymphoma patients. Methods Ten patients who had been treated for Hodgkin’s lymphoma and had received GnRHa...
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| Veröffentlicht in: | Archives of gynecology and obstetrics 2010-07, Vol.282 (1), p.83-88 |
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| container_title | Archives of gynecology and obstetrics |
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| creator | Nitzschke, Markus Raddatz, Juliane Bohlmann, Michael K. Stute, Petra Strowitzki, Thomas von Wolff, Michael |
| description | Purpose
To determine the protective effect of gonadotropin-releasing hormone analogs (GnRHa) using several ultrasound and endocrine markers to detect ultrastructural ovarian damage in Hodgkin’s lymphoma patients.
Methods
Ten patients who had been treated for Hodgkin’s lymphoma and had received GnRHa to protect ovarian function were matched with patients at similar age, who had received the same chemotherapy regimens without GnRHa. In addition, ten healthy women at the same age were matched to the study groups to compare ovarian markers. Blood samples were drawn to determine anti-Müllerian hormone, Inhibin B, follicle-stimulating hormone and transvaginal ultrasound scans were performed to determine antral follicle count and ovarian volume. All women were asked about their menstrual cycle pattern.
Results
No difference was found when comparing the ovarian parameters of both study groups. Compared with healthy women, all ovarian parameters in the Hodgkin’s lymphoma patients were significantly different.
Conclusions
The results of this study demonstrate ultrastructural ovarian damage in Hodgkin’s lymphoma patients irrespective of GnRHa co-treatment. These findings do not support previous studies, showing GnRHa to protect ovarian function. |
| doi_str_mv | 10.1007/s00404-009-1308-5 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_2261879871</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2261879871</sourcerecordid><originalsourceid>FETCH-LOGICAL-c382t-fd616c7df6436a989abfb15e4d0c61ab32d3285c4e06cb63372fd5d122d8f2103</originalsourceid><addsrcrecordid>eNp1kM1q3DAUhUVJaKZpHyCbIuja7b2SLcvLEJpMIVAozVrIkjzjiW25-gnMrq-R18uTxMMMZJXVvXDPOZfzEXKF8B0B6h8RoISyAGgK5CCL6gNZYclZATXiGVlBc9hB1BfkU4w7AGRSio_kAptG1CVUK5Lvpj9rqic9-E2k1tPJJzoHn5xJ1D_p0LtIu-BHarZu9Gnrgp73RT_ZbJyleUhBxxSySTnogfbTLof9Muja281jP738f4502I_z1o-azjr1bkrxMznv9BDdl9O8JA-3P__erIv733e_bq7vC8MlS0VnBQpT206UXOhGNrrtWqxcacEI1C1nljNZmdKBMK3gvGadrSwyZmXHEPgl-XbMXRr9yy4mtfM5LGWjYkygrBtZ46LCo8oEH2NwnZpDP-qwVwjqAFodQasFtDqAVtXi-XpKzu3o7JvjRHYRsKMgLqdp48Lb6_dTXwHuY4vG</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2261879871</pqid></control><display><type>article</type><title>GnRH analogs do not protect ovaries from chemotherapy-induced ultrastructural injury in Hodgkin’s lymphoma patients</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Nitzschke, Markus ; Raddatz, Juliane ; Bohlmann, Michael K. ; Stute, Petra ; Strowitzki, Thomas ; von Wolff, Michael</creator><creatorcontrib>Nitzschke, Markus ; Raddatz, Juliane ; Bohlmann, Michael K. ; Stute, Petra ; Strowitzki, Thomas ; von Wolff, Michael</creatorcontrib><description>Purpose
To determine the protective effect of gonadotropin-releasing hormone analogs (GnRHa) using several ultrasound and endocrine markers to detect ultrastructural ovarian damage in Hodgkin’s lymphoma patients.
Methods
Ten patients who had been treated for Hodgkin’s lymphoma and had received GnRHa to protect ovarian function were matched with patients at similar age, who had received the same chemotherapy regimens without GnRHa. In addition, ten healthy women at the same age were matched to the study groups to compare ovarian markers. Blood samples were drawn to determine anti-Müllerian hormone, Inhibin B, follicle-stimulating hormone and transvaginal ultrasound scans were performed to determine antral follicle count and ovarian volume. All women were asked about their menstrual cycle pattern.
Results
No difference was found when comparing the ovarian parameters of both study groups. Compared with healthy women, all ovarian parameters in the Hodgkin’s lymphoma patients were significantly different.
Conclusions
The results of this study demonstrate ultrastructural ovarian damage in Hodgkin’s lymphoma patients irrespective of GnRHa co-treatment. These findings do not support previous studies, showing GnRHa to protect ovarian function.</description><identifier>ISSN: 0932-0067</identifier><identifier>EISSN: 1432-0711</identifier><identifier>DOI: 10.1007/s00404-009-1308-5</identifier><identifier>PMID: 19967405</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer-Verlag</publisher><subject>Adolescent ; Adult ; Anti-Mullerian Hormone - blood ; Antineoplastic Combined Chemotherapy Protocols - adverse effects ; Antineoplastic Combined Chemotherapy Protocols - therapeutic use ; Case-Control Studies ; Chemotherapy ; Endocrinology ; Female ; Follicle Stimulating Hormone - blood ; Gonadotropin-Releasing Hormone - agonists ; Gonadotropin-Releasing Hormone - pharmacology ; Gynecologic Oncology ; Gynecology ; Health risk assessment ; Hodgkin Disease - blood ; Hodgkin Disease - drug therapy ; Hodgkin Disease - radiotherapy ; Human Genetics ; Humans ; Inhibins - blood ; Lymphoma ; Medicine ; Medicine & Public Health ; Obstetrics/Perinatology/Midwifery ; Ovarian Diseases - blood ; Ovarian Diseases - chemically induced ; Ovary - drug effects ; Ovary - pathology ; Ovary - ultrastructure ; Primary Ovarian Insufficiency - blood ; Primary Ovarian Insufficiency - chemically induced ; Primary Ovarian Insufficiency - prevention & control ; Ultrasonic imaging ; Ultrasonography ; Young Adult</subject><ispartof>Archives of gynecology and obstetrics, 2010-07, Vol.282 (1), p.83-88</ispartof><rights>Springer-Verlag 2009</rights><rights>Archives of Gynecology and Obstetrics is a copyright of Springer, (2009). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c382t-fd616c7df6436a989abfb15e4d0c61ab32d3285c4e06cb63372fd5d122d8f2103</citedby><cites>FETCH-LOGICAL-c382t-fd616c7df6436a989abfb15e4d0c61ab32d3285c4e06cb63372fd5d122d8f2103</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00404-009-1308-5$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00404-009-1308-5$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19967405$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nitzschke, Markus</creatorcontrib><creatorcontrib>Raddatz, Juliane</creatorcontrib><creatorcontrib>Bohlmann, Michael K.</creatorcontrib><creatorcontrib>Stute, Petra</creatorcontrib><creatorcontrib>Strowitzki, Thomas</creatorcontrib><creatorcontrib>von Wolff, Michael</creatorcontrib><title>GnRH analogs do not protect ovaries from chemotherapy-induced ultrastructural injury in Hodgkin’s lymphoma patients</title><title>Archives of gynecology and obstetrics</title><addtitle>Arch Gynecol Obstet</addtitle><addtitle>Arch Gynecol Obstet</addtitle><description>Purpose
To determine the protective effect of gonadotropin-releasing hormone analogs (GnRHa) using several ultrasound and endocrine markers to detect ultrastructural ovarian damage in Hodgkin’s lymphoma patients.
Methods
Ten patients who had been treated for Hodgkin’s lymphoma and had received GnRHa to protect ovarian function were matched with patients at similar age, who had received the same chemotherapy regimens without GnRHa. In addition, ten healthy women at the same age were matched to the study groups to compare ovarian markers. Blood samples were drawn to determine anti-Müllerian hormone, Inhibin B, follicle-stimulating hormone and transvaginal ultrasound scans were performed to determine antral follicle count and ovarian volume. All women were asked about their menstrual cycle pattern.
Results
No difference was found when comparing the ovarian parameters of both study groups. Compared with healthy women, all ovarian parameters in the Hodgkin’s lymphoma patients were significantly different.
Conclusions
The results of this study demonstrate ultrastructural ovarian damage in Hodgkin’s lymphoma patients irrespective of GnRHa co-treatment. These findings do not support previous studies, showing GnRHa to protect ovarian function.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Anti-Mullerian Hormone - blood</subject><subject>Antineoplastic Combined Chemotherapy Protocols - adverse effects</subject><subject>Antineoplastic Combined Chemotherapy Protocols - therapeutic use</subject><subject>Case-Control Studies</subject><subject>Chemotherapy</subject><subject>Endocrinology</subject><subject>Female</subject><subject>Follicle Stimulating Hormone - blood</subject><subject>Gonadotropin-Releasing Hormone - agonists</subject><subject>Gonadotropin-Releasing Hormone - pharmacology</subject><subject>Gynecologic Oncology</subject><subject>Gynecology</subject><subject>Health risk assessment</subject><subject>Hodgkin Disease - blood</subject><subject>Hodgkin Disease - drug therapy</subject><subject>Hodgkin Disease - radiotherapy</subject><subject>Human Genetics</subject><subject>Humans</subject><subject>Inhibins - blood</subject><subject>Lymphoma</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Obstetrics/Perinatology/Midwifery</subject><subject>Ovarian Diseases - blood</subject><subject>Ovarian Diseases - chemically induced</subject><subject>Ovary - drug effects</subject><subject>Ovary - pathology</subject><subject>Ovary - ultrastructure</subject><subject>Primary Ovarian Insufficiency - blood</subject><subject>Primary Ovarian Insufficiency - chemically induced</subject><subject>Primary Ovarian Insufficiency - prevention & control</subject><subject>Ultrasonic imaging</subject><subject>Ultrasonography</subject><subject>Young Adult</subject><issn>0932-0067</issn><issn>1432-0711</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp1kM1q3DAUhUVJaKZpHyCbIuja7b2SLcvLEJpMIVAozVrIkjzjiW25-gnMrq-R18uTxMMMZJXVvXDPOZfzEXKF8B0B6h8RoISyAGgK5CCL6gNZYclZATXiGVlBc9hB1BfkU4w7AGRSio_kAptG1CVUK5Lvpj9rqic9-E2k1tPJJzoHn5xJ1D_p0LtIu-BHarZu9Gnrgp73RT_ZbJyleUhBxxSySTnogfbTLof9Muja281jP738f4502I_z1o-azjr1bkrxMznv9BDdl9O8JA-3P__erIv733e_bq7vC8MlS0VnBQpT206UXOhGNrrtWqxcacEI1C1nljNZmdKBMK3gvGadrSwyZmXHEPgl-XbMXRr9yy4mtfM5LGWjYkygrBtZ46LCo8oEH2NwnZpDP-qwVwjqAFodQasFtDqAVtXi-XpKzu3o7JvjRHYRsKMgLqdp48Lb6_dTXwHuY4vG</recordid><startdate>20100701</startdate><enddate>20100701</enddate><creator>Nitzschke, Markus</creator><creator>Raddatz, Juliane</creator><creator>Bohlmann, Michael K.</creator><creator>Stute, Petra</creator><creator>Strowitzki, Thomas</creator><creator>von Wolff, Michael</creator><general>Springer-Verlag</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope></search><sort><creationdate>20100701</creationdate><title>GnRH analogs do not protect ovaries from chemotherapy-induced ultrastructural injury in Hodgkin’s lymphoma patients</title><author>Nitzschke, Markus ; Raddatz, Juliane ; Bohlmann, Michael K. ; Stute, Petra ; Strowitzki, Thomas ; von Wolff, Michael</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c382t-fd616c7df6436a989abfb15e4d0c61ab32d3285c4e06cb63372fd5d122d8f2103</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Anti-Mullerian Hormone - blood</topic><topic>Antineoplastic Combined Chemotherapy Protocols - adverse effects</topic><topic>Antineoplastic Combined Chemotherapy Protocols - therapeutic use</topic><topic>Case-Control Studies</topic><topic>Chemotherapy</topic><topic>Endocrinology</topic><topic>Female</topic><topic>Follicle Stimulating Hormone - blood</topic><topic>Gonadotropin-Releasing Hormone - agonists</topic><topic>Gonadotropin-Releasing Hormone - pharmacology</topic><topic>Gynecologic Oncology</topic><topic>Gynecology</topic><topic>Health risk assessment</topic><topic>Hodgkin Disease - blood</topic><topic>Hodgkin Disease - drug therapy</topic><topic>Hodgkin Disease - radiotherapy</topic><topic>Human Genetics</topic><topic>Humans</topic><topic>Inhibins - blood</topic><topic>Lymphoma</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Obstetrics/Perinatology/Midwifery</topic><topic>Ovarian Diseases - blood</topic><topic>Ovarian Diseases - chemically induced</topic><topic>Ovary - drug effects</topic><topic>Ovary - pathology</topic><topic>Ovary - ultrastructure</topic><topic>Primary Ovarian Insufficiency - blood</topic><topic>Primary Ovarian Insufficiency - chemically induced</topic><topic>Primary Ovarian Insufficiency - prevention & control</topic><topic>Ultrasonic imaging</topic><topic>Ultrasonography</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nitzschke, Markus</creatorcontrib><creatorcontrib>Raddatz, Juliane</creatorcontrib><creatorcontrib>Bohlmann, Michael K.</creatorcontrib><creatorcontrib>Stute, Petra</creatorcontrib><creatorcontrib>Strowitzki, Thomas</creatorcontrib><creatorcontrib>von Wolff, Michael</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><jtitle>Archives of gynecology and obstetrics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nitzschke, Markus</au><au>Raddatz, Juliane</au><au>Bohlmann, Michael K.</au><au>Stute, Petra</au><au>Strowitzki, Thomas</au><au>von Wolff, Michael</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>GnRH analogs do not protect ovaries from chemotherapy-induced ultrastructural injury in Hodgkin’s lymphoma patients</atitle><jtitle>Archives of gynecology and obstetrics</jtitle><stitle>Arch Gynecol Obstet</stitle><addtitle>Arch Gynecol Obstet</addtitle><date>2010-07-01</date><risdate>2010</risdate><volume>282</volume><issue>1</issue><spage>83</spage><epage>88</epage><pages>83-88</pages><issn>0932-0067</issn><eissn>1432-0711</eissn><abstract>Purpose
To determine the protective effect of gonadotropin-releasing hormone analogs (GnRHa) using several ultrasound and endocrine markers to detect ultrastructural ovarian damage in Hodgkin’s lymphoma patients.
Methods
Ten patients who had been treated for Hodgkin’s lymphoma and had received GnRHa to protect ovarian function were matched with patients at similar age, who had received the same chemotherapy regimens without GnRHa. In addition, ten healthy women at the same age were matched to the study groups to compare ovarian markers. Blood samples were drawn to determine anti-Müllerian hormone, Inhibin B, follicle-stimulating hormone and transvaginal ultrasound scans were performed to determine antral follicle count and ovarian volume. All women were asked about their menstrual cycle pattern.
Results
No difference was found when comparing the ovarian parameters of both study groups. Compared with healthy women, all ovarian parameters in the Hodgkin’s lymphoma patients were significantly different.
Conclusions
The results of this study demonstrate ultrastructural ovarian damage in Hodgkin’s lymphoma patients irrespective of GnRHa co-treatment. These findings do not support previous studies, showing GnRHa to protect ovarian function.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer-Verlag</pub><pmid>19967405</pmid><doi>10.1007/s00404-009-1308-5</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0932-0067 |
| ispartof | Archives of gynecology and obstetrics, 2010-07, Vol.282 (1), p.83-88 |
| issn | 0932-0067 1432-0711 |
| language | eng |
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| subjects | Adolescent Adult Anti-Mullerian Hormone - blood Antineoplastic Combined Chemotherapy Protocols - adverse effects Antineoplastic Combined Chemotherapy Protocols - therapeutic use Case-Control Studies Chemotherapy Endocrinology Female Follicle Stimulating Hormone - blood Gonadotropin-Releasing Hormone - agonists Gonadotropin-Releasing Hormone - pharmacology Gynecologic Oncology Gynecology Health risk assessment Hodgkin Disease - blood Hodgkin Disease - drug therapy Hodgkin Disease - radiotherapy Human Genetics Humans Inhibins - blood Lymphoma Medicine Medicine & Public Health Obstetrics/Perinatology/Midwifery Ovarian Diseases - blood Ovarian Diseases - chemically induced Ovary - drug effects Ovary - pathology Ovary - ultrastructure Primary Ovarian Insufficiency - blood Primary Ovarian Insufficiency - chemically induced Primary Ovarian Insufficiency - prevention & control Ultrasonic imaging Ultrasonography Young Adult |
| title | GnRH analogs do not protect ovaries from chemotherapy-induced ultrastructural injury in Hodgkin’s lymphoma patients |
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