Chronic exposure to urban air pollution from Buenos Aires: the ocular mucosa as an early biomarker
Air pollution represents a major health problem in megacities, bringing about 8 million deaths every year. The aim of the study was to evaluate in vivo the ocular and respiratory mucosa biological response after chronic exposure to urban air particles from Buenos Aires (UAP-BA). BALB/c mice were exp...
Gespeichert in:
| Veröffentlicht in: | Environmental science and pollution research international 2019-09, Vol.26 (26), p.27444-27456 |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 27456 |
|---|---|
| container_issue | 26 |
| container_start_page | 27444 |
| container_title | Environmental science and pollution research international |
| container_volume | 26 |
| creator | Maglione, Guillermo A. Kurtz, Melisa L. Orona, Nadia S. Astort, Francisco Busso, Iván Tavera Mandalunis, Patricia M. Berra, Alejandro Tasat, Deborah R. |
| description | Air pollution represents a major health problem in megacities, bringing about 8 million deaths every year. The aim of the study was to evaluate in vivo the ocular and respiratory mucosa biological response after chronic exposure to urban air particles from Buenos Aires (UAP-BA). BALB/c mice were exposed to UAP-BA or filtered air for 1, 6, 9, and 12 months. After exposure, histology, histomorphometry, and IL-6 proinflammatory cytokine level were evaluated in the respiratory and ocular mucosa. Total cell number and differential cell count were determined in the brochoalveolar lavage fluid. In the lung, chronic exposure to UAP-BA induced reduction of the alveolar space, polymorhonuclear cell recruitment, and goblet cell hyperplasia. In the ocular surface, UAP-BA induced an initial mucin positive cells rise followed by a decline through time, while IL-6 level increased at the latest point-time assayed. Our results showed that the respiratory and the ocular mucosas respond differently to UAP-BA. Being that lung and ocular mucosa diseases may be triggered and/or exacerbated by chronic exposure to urban air PM, the inhabitants of Buenos Aires whom are chronically exposed to environmental urban air pollution may be considered a subpopulation at risk. Based on our results, we propose the ocular mucosa as a reliable and more accessible surrogate for pulmonary mucosa environmental toxicity that might also serve as an earlier biomarker for air pollution adverse impact on health. |
| doi_str_mv | 10.1007/s11356-019-05966-6 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_2260499641</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2260499641</sourcerecordid><originalsourceid>FETCH-LOGICAL-c443t-dc74171f2fc0b03891990fc3f2025a616276beb447d4370548a9395a49cc65343</originalsourceid><addsrcrecordid>eNp9kMtOwzAQRS0EoqXwAyyQJdYBPyZ2zQ4qXlIlNrC2HNehKWkc7Fiif4-hBXasZjHn3hkdhE4puaCEyMtIKS9FQagqSKmEKMQeGlNBoZCg1D4aEwVQUA4wQkcxrghhRDF5iEacciYpwBhVs2XwXWOx--h9TMHhweMUKtNh0wTc-7ZNQ-M7XAe_xjfJdT7i6ya4eIWHpcPeptYEvE7WR4NNxDnoTGg3uGr82oQ3F47RQW3a6E52c4Je7m6fZw_F_On-cXY9LywAH4qFlUAlrVltSUX4VFGlSG15zQgrjaCCSVG5CkAugEtSwtQorkoDylpRcuATdL7t7YN_Ty4OeuVT6PJJzZggWYkAmim2pWzwMQZX6z40-dGNpkR_adVbrTpr1d9atcihs111qtZu8Rv58ZgBvgViXnWvLvzd_qf2E9sBgd0</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2260499641</pqid></control><display><type>article</type><title>Chronic exposure to urban air pollution from Buenos Aires: the ocular mucosa as an early biomarker</title><source>MEDLINE</source><source>Springer Online Journals【Remote access available】</source><creator>Maglione, Guillermo A. ; Kurtz, Melisa L. ; Orona, Nadia S. ; Astort, Francisco ; Busso, Iván Tavera ; Mandalunis, Patricia M. ; Berra, Alejandro ; Tasat, Deborah R.</creator><creatorcontrib>Maglione, Guillermo A. ; Kurtz, Melisa L. ; Orona, Nadia S. ; Astort, Francisco ; Busso, Iván Tavera ; Mandalunis, Patricia M. ; Berra, Alejandro ; Tasat, Deborah R.</creatorcontrib><description>Air pollution represents a major health problem in megacities, bringing about 8 million deaths every year. The aim of the study was to evaluate in vivo the ocular and respiratory mucosa biological response after chronic exposure to urban air particles from Buenos Aires (UAP-BA). BALB/c mice were exposed to UAP-BA or filtered air for 1, 6, 9, and 12 months. After exposure, histology, histomorphometry, and IL-6 proinflammatory cytokine level were evaluated in the respiratory and ocular mucosa. Total cell number and differential cell count were determined in the brochoalveolar lavage fluid. In the lung, chronic exposure to UAP-BA induced reduction of the alveolar space, polymorhonuclear cell recruitment, and goblet cell hyperplasia. In the ocular surface, UAP-BA induced an initial mucin positive cells rise followed by a decline through time, while IL-6 level increased at the latest point-time assayed. Our results showed that the respiratory and the ocular mucosas respond differently to UAP-BA. Being that lung and ocular mucosa diseases may be triggered and/or exacerbated by chronic exposure to urban air PM, the inhabitants of Buenos Aires whom are chronically exposed to environmental urban air pollution may be considered a subpopulation at risk. Based on our results, we propose the ocular mucosa as a reliable and more accessible surrogate for pulmonary mucosa environmental toxicity that might also serve as an earlier biomarker for air pollution adverse impact on health.</description><identifier>ISSN: 0944-1344</identifier><identifier>EISSN: 1614-7499</identifier><identifier>DOI: 10.1007/s11356-019-05966-6</identifier><identifier>PMID: 31327144</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Air pollution ; Air Pollution - adverse effects ; Air Pollution - analysis ; Alveoli ; Animals ; Aquatic Pollution ; Argentina ; Atmospheric Protection/Air Quality Control/Air Pollution ; Biocompatibility ; Biomarkers ; Biomarkers - analysis ; Bronchoalveolar Lavage Fluid - cytology ; Cell number ; Chronic exposure ; Earth and Environmental Science ; Ecotoxicology ; Environment ; Environmental Chemistry ; Environmental Exposure - adverse effects ; Environmental Health ; Environmental science ; Exposure ; Eye - drug effects ; Eye - pathology ; Female ; Histology ; Histomorphometry ; Hyperplasia ; In vivo methods and tests ; Inflammation ; Interleukin 6 ; Interleukin-6 - analysis ; Interleukin-6 - genetics ; Lung - drug effects ; Lung - pathology ; Lung diseases ; Lungs ; Megacities ; Mice ; Mice, Inbred BALB C ; Mucin ; Mucosa ; Mucous Membrane - drug effects ; Outdoor air quality ; Particulate emissions ; Particulate Matter - adverse effects ; Particulate Matter - analysis ; Particulate Matter - chemistry ; Pollution ; Research Article ; Toxicity ; Toxicity Tests, Chronic ; Urbanization ; Waste Water Technology ; Water Management ; Water Pollution Control</subject><ispartof>Environmental science and pollution research international, 2019-09, Vol.26 (26), p.27444-27456</ispartof><rights>Springer-Verlag GmbH Germany, part of Springer Nature 2019</rights><rights>Environmental Science and Pollution Research is a copyright of Springer, (2019). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c443t-dc74171f2fc0b03891990fc3f2025a616276beb447d4370548a9395a49cc65343</citedby><cites>FETCH-LOGICAL-c443t-dc74171f2fc0b03891990fc3f2025a616276beb447d4370548a9395a49cc65343</cites><orcidid>0000-0001-8756-4092</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11356-019-05966-6$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11356-019-05966-6$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27923,27924,41487,42556,51318</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31327144$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Maglione, Guillermo A.</creatorcontrib><creatorcontrib>Kurtz, Melisa L.</creatorcontrib><creatorcontrib>Orona, Nadia S.</creatorcontrib><creatorcontrib>Astort, Francisco</creatorcontrib><creatorcontrib>Busso, Iván Tavera</creatorcontrib><creatorcontrib>Mandalunis, Patricia M.</creatorcontrib><creatorcontrib>Berra, Alejandro</creatorcontrib><creatorcontrib>Tasat, Deborah R.</creatorcontrib><title>Chronic exposure to urban air pollution from Buenos Aires: the ocular mucosa as an early biomarker</title><title>Environmental science and pollution research international</title><addtitle>Environ Sci Pollut Res</addtitle><addtitle>Environ Sci Pollut Res Int</addtitle><description>Air pollution represents a major health problem in megacities, bringing about 8 million deaths every year. The aim of the study was to evaluate in vivo the ocular and respiratory mucosa biological response after chronic exposure to urban air particles from Buenos Aires (UAP-BA). BALB/c mice were exposed to UAP-BA or filtered air for 1, 6, 9, and 12 months. After exposure, histology, histomorphometry, and IL-6 proinflammatory cytokine level were evaluated in the respiratory and ocular mucosa. Total cell number and differential cell count were determined in the brochoalveolar lavage fluid. In the lung, chronic exposure to UAP-BA induced reduction of the alveolar space, polymorhonuclear cell recruitment, and goblet cell hyperplasia. In the ocular surface, UAP-BA induced an initial mucin positive cells rise followed by a decline through time, while IL-6 level increased at the latest point-time assayed. Our results showed that the respiratory and the ocular mucosas respond differently to UAP-BA. Being that lung and ocular mucosa diseases may be triggered and/or exacerbated by chronic exposure to urban air PM, the inhabitants of Buenos Aires whom are chronically exposed to environmental urban air pollution may be considered a subpopulation at risk. Based on our results, we propose the ocular mucosa as a reliable and more accessible surrogate for pulmonary mucosa environmental toxicity that might also serve as an earlier biomarker for air pollution adverse impact on health.</description><subject>Air pollution</subject><subject>Air Pollution - adverse effects</subject><subject>Air Pollution - analysis</subject><subject>Alveoli</subject><subject>Animals</subject><subject>Aquatic Pollution</subject><subject>Argentina</subject><subject>Atmospheric Protection/Air Quality Control/Air Pollution</subject><subject>Biocompatibility</subject><subject>Biomarkers</subject><subject>Biomarkers - analysis</subject><subject>Bronchoalveolar Lavage Fluid - cytology</subject><subject>Cell number</subject><subject>Chronic exposure</subject><subject>Earth and Environmental Science</subject><subject>Ecotoxicology</subject><subject>Environment</subject><subject>Environmental Chemistry</subject><subject>Environmental Exposure - adverse effects</subject><subject>Environmental Health</subject><subject>Environmental science</subject><subject>Exposure</subject><subject>Eye - drug effects</subject><subject>Eye - pathology</subject><subject>Female</subject><subject>Histology</subject><subject>Histomorphometry</subject><subject>Hyperplasia</subject><subject>In vivo methods and tests</subject><subject>Inflammation</subject><subject>Interleukin 6</subject><subject>Interleukin-6 - analysis</subject><subject>Interleukin-6 - genetics</subject><subject>Lung - drug effects</subject><subject>Lung - pathology</subject><subject>Lung diseases</subject><subject>Lungs</subject><subject>Megacities</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Mucin</subject><subject>Mucosa</subject><subject>Mucous Membrane - drug effects</subject><subject>Outdoor air quality</subject><subject>Particulate emissions</subject><subject>Particulate Matter - adverse effects</subject><subject>Particulate Matter - analysis</subject><subject>Particulate Matter - chemistry</subject><subject>Pollution</subject><subject>Research Article</subject><subject>Toxicity</subject><subject>Toxicity Tests, Chronic</subject><subject>Urbanization</subject><subject>Waste Water Technology</subject><subject>Water Management</subject><subject>Water Pollution Control</subject><issn>0944-1344</issn><issn>1614-7499</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kMtOwzAQRS0EoqXwAyyQJdYBPyZ2zQ4qXlIlNrC2HNehKWkc7Fiif4-hBXasZjHn3hkdhE4puaCEyMtIKS9FQagqSKmEKMQeGlNBoZCg1D4aEwVQUA4wQkcxrghhRDF5iEacciYpwBhVs2XwXWOx--h9TMHhweMUKtNh0wTc-7ZNQ-M7XAe_xjfJdT7i6ya4eIWHpcPeptYEvE7WR4NNxDnoTGg3uGr82oQ3F47RQW3a6E52c4Je7m6fZw_F_On-cXY9LywAH4qFlUAlrVltSUX4VFGlSG15zQgrjaCCSVG5CkAugEtSwtQorkoDylpRcuATdL7t7YN_Ty4OeuVT6PJJzZggWYkAmim2pWzwMQZX6z40-dGNpkR_adVbrTpr1d9atcihs111qtZu8Rv58ZgBvgViXnWvLvzd_qf2E9sBgd0</recordid><startdate>20190901</startdate><enddate>20190901</enddate><creator>Maglione, Guillermo A.</creator><creator>Kurtz, Melisa L.</creator><creator>Orona, Nadia S.</creator><creator>Astort, Francisco</creator><creator>Busso, Iván Tavera</creator><creator>Mandalunis, Patricia M.</creator><creator>Berra, Alejandro</creator><creator>Tasat, Deborah R.</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7SN</scope><scope>7T7</scope><scope>7TV</scope><scope>7U7</scope><scope>7WY</scope><scope>7WZ</scope><scope>7X7</scope><scope>7XB</scope><scope>87Z</scope><scope>88E</scope><scope>88I</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8FL</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BEZIV</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FRNLG</scope><scope>FYUFA</scope><scope>F~G</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K60</scope><scope>K6~</scope><scope>K9.</scope><scope>L.-</scope><scope>M0C</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7N</scope><scope>P64</scope><scope>PATMY</scope><scope>PQBIZ</scope><scope>PQBZA</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PYCSY</scope><scope>Q9U</scope><orcidid>https://orcid.org/0000-0001-8756-4092</orcidid></search><sort><creationdate>20190901</creationdate><title>Chronic exposure to urban air pollution from Buenos Aires: the ocular mucosa as an early biomarker</title><author>Maglione, Guillermo A. ; Kurtz, Melisa L. ; Orona, Nadia S. ; Astort, Francisco ; Busso, Iván Tavera ; Mandalunis, Patricia M. ; Berra, Alejandro ; Tasat, Deborah R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c443t-dc74171f2fc0b03891990fc3f2025a616276beb447d4370548a9395a49cc65343</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Air pollution</topic><topic>Air Pollution - adverse effects</topic><topic>Air Pollution - analysis</topic><topic>Alveoli</topic><topic>Animals</topic><topic>Aquatic Pollution</topic><topic>Argentina</topic><topic>Atmospheric Protection/Air Quality Control/Air Pollution</topic><topic>Biocompatibility</topic><topic>Biomarkers</topic><topic>Biomarkers - analysis</topic><topic>Bronchoalveolar Lavage Fluid - cytology</topic><topic>Cell number</topic><topic>Chronic exposure</topic><topic>Earth and Environmental Science</topic><topic>Ecotoxicology</topic><topic>Environment</topic><topic>Environmental Chemistry</topic><topic>Environmental Exposure - adverse effects</topic><topic>Environmental Health</topic><topic>Environmental science</topic><topic>Exposure</topic><topic>Eye - drug effects</topic><topic>Eye - pathology</topic><topic>Female</topic><topic>Histology</topic><topic>Histomorphometry</topic><topic>Hyperplasia</topic><topic>In vivo methods and tests</topic><topic>Inflammation</topic><topic>Interleukin 6</topic><topic>Interleukin-6 - analysis</topic><topic>Interleukin-6 - genetics</topic><topic>Lung - drug effects</topic><topic>Lung - pathology</topic><topic>Lung diseases</topic><topic>Lungs</topic><topic>Megacities</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>Mucin</topic><topic>Mucosa</topic><topic>Mucous Membrane - drug effects</topic><topic>Outdoor air quality</topic><topic>Particulate emissions</topic><topic>Particulate Matter - adverse effects</topic><topic>Particulate Matter - analysis</topic><topic>Particulate Matter - chemistry</topic><topic>Pollution</topic><topic>Research Article</topic><topic>Toxicity</topic><topic>Toxicity Tests, Chronic</topic><topic>Urbanization</topic><topic>Waste Water Technology</topic><topic>Water Management</topic><topic>Water Pollution Control</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Maglione, Guillermo A.</creatorcontrib><creatorcontrib>Kurtz, Melisa L.</creatorcontrib><creatorcontrib>Orona, Nadia S.</creatorcontrib><creatorcontrib>Astort, Francisco</creatorcontrib><creatorcontrib>Busso, Iván Tavera</creatorcontrib><creatorcontrib>Mandalunis, Patricia M.</creatorcontrib><creatorcontrib>Berra, Alejandro</creatorcontrib><creatorcontrib>Tasat, Deborah R.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Ecology Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Pollution Abstracts</collection><collection>Toxicology Abstracts</collection><collection>ABI/INFORM Collection (ProQuest)</collection><collection>ABI/INFORM Global (PDF only)</collection><collection>Health & Medical Collection (Proquest)</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>ABI/INFORM Collection</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest Public Health Database</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ABI/INFORM Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>Business Premium Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Engineering Research Database</collection><collection>Business Premium Collection (Alumni)</collection><collection>Health Research Premium Collection</collection><collection>ABI/INFORM Global (Corporate)</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Business Collection (Alumni Edition)</collection><collection>ProQuest Business Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ABI/INFORM Professional Advanced</collection><collection>ABI/INFORM Global</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>Science Database (ProQuest)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environmental Science Database</collection><collection>One Business (ProQuest)</collection><collection>ProQuest One Business (Alumni)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>Environmental Science Collection</collection><collection>ProQuest Central Basic</collection><jtitle>Environmental science and pollution research international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Maglione, Guillermo A.</au><au>Kurtz, Melisa L.</au><au>Orona, Nadia S.</au><au>Astort, Francisco</au><au>Busso, Iván Tavera</au><au>Mandalunis, Patricia M.</au><au>Berra, Alejandro</au><au>Tasat, Deborah R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Chronic exposure to urban air pollution from Buenos Aires: the ocular mucosa as an early biomarker</atitle><jtitle>Environmental science and pollution research international</jtitle><stitle>Environ Sci Pollut Res</stitle><addtitle>Environ Sci Pollut Res Int</addtitle><date>2019-09-01</date><risdate>2019</risdate><volume>26</volume><issue>26</issue><spage>27444</spage><epage>27456</epage><pages>27444-27456</pages><issn>0944-1344</issn><eissn>1614-7499</eissn><abstract>Air pollution represents a major health problem in megacities, bringing about 8 million deaths every year. The aim of the study was to evaluate in vivo the ocular and respiratory mucosa biological response after chronic exposure to urban air particles from Buenos Aires (UAP-BA). BALB/c mice were exposed to UAP-BA or filtered air for 1, 6, 9, and 12 months. After exposure, histology, histomorphometry, and IL-6 proinflammatory cytokine level were evaluated in the respiratory and ocular mucosa. Total cell number and differential cell count were determined in the brochoalveolar lavage fluid. In the lung, chronic exposure to UAP-BA induced reduction of the alveolar space, polymorhonuclear cell recruitment, and goblet cell hyperplasia. In the ocular surface, UAP-BA induced an initial mucin positive cells rise followed by a decline through time, while IL-6 level increased at the latest point-time assayed. Our results showed that the respiratory and the ocular mucosas respond differently to UAP-BA. Being that lung and ocular mucosa diseases may be triggered and/or exacerbated by chronic exposure to urban air PM, the inhabitants of Buenos Aires whom are chronically exposed to environmental urban air pollution may be considered a subpopulation at risk. Based on our results, we propose the ocular mucosa as a reliable and more accessible surrogate for pulmonary mucosa environmental toxicity that might also serve as an earlier biomarker for air pollution adverse impact on health.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>31327144</pmid><doi>10.1007/s11356-019-05966-6</doi><tpages>13</tpages><orcidid>https://orcid.org/0000-0001-8756-4092</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0944-1344 |
| ispartof | Environmental science and pollution research international, 2019-09, Vol.26 (26), p.27444-27456 |
| issn | 0944-1344 1614-7499 |
| language | eng |
| recordid | cdi_proquest_journals_2260499641 |
| source | MEDLINE; Springer Online Journals【Remote access available】 |
| subjects | Air pollution Air Pollution - adverse effects Air Pollution - analysis Alveoli Animals Aquatic Pollution Argentina Atmospheric Protection/Air Quality Control/Air Pollution Biocompatibility Biomarkers Biomarkers - analysis Bronchoalveolar Lavage Fluid - cytology Cell number Chronic exposure Earth and Environmental Science Ecotoxicology Environment Environmental Chemistry Environmental Exposure - adverse effects Environmental Health Environmental science Exposure Eye - drug effects Eye - pathology Female Histology Histomorphometry Hyperplasia In vivo methods and tests Inflammation Interleukin 6 Interleukin-6 - analysis Interleukin-6 - genetics Lung - drug effects Lung - pathology Lung diseases Lungs Megacities Mice Mice, Inbred BALB C Mucin Mucosa Mucous Membrane - drug effects Outdoor air quality Particulate emissions Particulate Matter - adverse effects Particulate Matter - analysis Particulate Matter - chemistry Pollution Research Article Toxicity Toxicity Tests, Chronic Urbanization Waste Water Technology Water Management Water Pollution Control |
| title | Chronic exposure to urban air pollution from Buenos Aires: the ocular mucosa as an early biomarker |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-10T15%3A28%3A48IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Chronic%20exposure%20to%20urban%20air%20pollution%20from%20Buenos%20Aires:%20the%20ocular%20mucosa%20as%20an%20early%20biomarker&rft.jtitle=Environmental%20science%20and%20pollution%20research%20international&rft.au=Maglione,%20Guillermo%20A.&rft.date=2019-09-01&rft.volume=26&rft.issue=26&rft.spage=27444&rft.epage=27456&rft.pages=27444-27456&rft.issn=0944-1344&rft.eissn=1614-7499&rft_id=info:doi/10.1007/s11356-019-05966-6&rft_dat=%3Cproquest_cross%3E2260499641%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2260499641&rft_id=info:pmid/31327144&rfr_iscdi=true |