Selenium-Rich Yeast Mitigates Aluminum-Mediated Testicular Toxicity by Blocking Oxidative Stress, Inhibiting NO Production, and Disturbing Ionic Homeostasis
Aluminum (Al) poisoning has been linked to the development of several reproductive system dysfunctions. Dietary supplementation with selenium-rich yeast (SeY) has been shown to prevent a variety of pathologic conditions. In the present study, the potential protect role of SeY on Al-induced testicula...
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| Veröffentlicht in: | Biological trace element research 2020-05, Vol.195 (1), p.170-177 |
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| description | Aluminum (Al) poisoning has been linked to the development of several reproductive system dysfunctions. Dietary supplementation with selenium-rich yeast (SeY) has been shown to prevent a variety of pathologic conditions. In the present study, the potential protect role of SeY on Al-induced testicular toxicity was evaluated, and the possible underlying mechanisms were discussed. Mice were treated with SeY (0.1 mg/kg) and/or Al (10 mg/kg) by oral gavage for 4 weeks. Histopathologic changes were observed in the testes of Al-treated mice. Oxidative stress, ionic disturbances, and the generation of NO systems are believed to have resulted in the observed pathology. Interestingly, SeY supplementation significantly inhibited the Al-induced histopathological and molecular changes and restored these indicators to levels observed in the control animals. These results suggest that SeY exerts a testis-protective effect against Al-induced toxicity through the reduction of oxidative stress, NO production, and the maintenance of ionic homeostasis. |
| doi_str_mv | 10.1007/s12011-019-01820-5 |
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Dietary supplementation with selenium-rich yeast (SeY) has been shown to prevent a variety of pathologic conditions. In the present study, the potential protect role of SeY on Al-induced testicular toxicity was evaluated, and the possible underlying mechanisms were discussed. Mice were treated with SeY (0.1 mg/kg) and/or Al (10 mg/kg) by oral gavage for 4 weeks. Histopathologic changes were observed in the testes of Al-treated mice. Oxidative stress, ionic disturbances, and the generation of NO systems are believed to have resulted in the observed pathology. Interestingly, SeY supplementation significantly inhibited the Al-induced histopathological and molecular changes and restored these indicators to levels observed in the control animals. These results suggest that SeY exerts a testis-protective effect against Al-induced toxicity through the reduction of oxidative stress, NO production, and the maintenance of ionic homeostasis.</description><identifier>ISSN: 0163-4984</identifier><identifier>EISSN: 1559-0720</identifier><identifier>DOI: 10.1007/s12011-019-01820-5</identifier><identifier>PMID: 31327124</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Aluminium ; Aluminum ; Aluminum - toxicity ; Animals ; Biochemistry ; Biological stress ; Biomedical and Life Sciences ; Biotechnology ; Dietary supplements ; Histopathology ; Homeostasis ; Homeostasis - drug effects ; Life Sciences ; Male ; Mice ; Mice, Inbred Strains ; Nitric Oxide - antagonists & inhibitors ; Nitric Oxide - biosynthesis ; Nutrition ; Oncology ; Oxidative stress ; Oxidative Stress - drug effects ; Pathology ; Reproductive system ; Saccharomyces cerevisiae - chemistry ; Selenium ; Selenium - administration & dosage ; Selenium - pharmacology ; Testes ; Testis - drug effects ; Testis - metabolism ; Toxicity ; Yeast ; Yeasts</subject><ispartof>Biological trace element research, 2020-05, Vol.195 (1), p.170-177</ispartof><rights>Springer Science+Business Media, LLC, part of Springer Nature 2019</rights><rights>Springer Science+Business Media, LLC, part of Springer Nature 2019.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-cf12005bcb4befc3a2bbcde9c19a8328e218aab9b1ffe1ce75e1f5111afcd00b3</citedby><cites>FETCH-LOGICAL-c375t-cf12005bcb4befc3a2bbcde9c19a8328e218aab9b1ffe1ce75e1f5111afcd00b3</cites><orcidid>0000-0002-1035-852X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12011-019-01820-5$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s12011-019-01820-5$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31327124$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cao, Changyu</creatorcontrib><creatorcontrib>Zhang, Haoji</creatorcontrib><creatorcontrib>Wang, Kai</creatorcontrib><creatorcontrib>Li, Xinran</creatorcontrib><title>Selenium-Rich Yeast Mitigates Aluminum-Mediated Testicular Toxicity by Blocking Oxidative Stress, Inhibiting NO Production, and Disturbing Ionic Homeostasis</title><title>Biological trace element research</title><addtitle>Biol Trace Elem Res</addtitle><addtitle>Biol Trace Elem Res</addtitle><description>Aluminum (Al) poisoning has been linked to the development of several reproductive system dysfunctions. Dietary supplementation with selenium-rich yeast (SeY) has been shown to prevent a variety of pathologic conditions. In the present study, the potential protect role of SeY on Al-induced testicular toxicity was evaluated, and the possible underlying mechanisms were discussed. Mice were treated with SeY (0.1 mg/kg) and/or Al (10 mg/kg) by oral gavage for 4 weeks. Histopathologic changes were observed in the testes of Al-treated mice. Oxidative stress, ionic disturbances, and the generation of NO systems are believed to have resulted in the observed pathology. Interestingly, SeY supplementation significantly inhibited the Al-induced histopathological and molecular changes and restored these indicators to levels observed in the control animals. These results suggest that SeY exerts a testis-protective effect against Al-induced toxicity through the reduction of oxidative stress, NO production, and the maintenance of ionic homeostasis.</description><subject>Aluminium</subject><subject>Aluminum</subject><subject>Aluminum - toxicity</subject><subject>Animals</subject><subject>Biochemistry</subject><subject>Biological stress</subject><subject>Biomedical and Life Sciences</subject><subject>Biotechnology</subject><subject>Dietary supplements</subject><subject>Histopathology</subject><subject>Homeostasis</subject><subject>Homeostasis - drug effects</subject><subject>Life Sciences</subject><subject>Male</subject><subject>Mice</subject><subject>Mice, Inbred Strains</subject><subject>Nitric Oxide - antagonists & inhibitors</subject><subject>Nitric Oxide - biosynthesis</subject><subject>Nutrition</subject><subject>Oncology</subject><subject>Oxidative stress</subject><subject>Oxidative Stress - drug effects</subject><subject>Pathology</subject><subject>Reproductive system</subject><subject>Saccharomyces cerevisiae - chemistry</subject><subject>Selenium</subject><subject>Selenium - administration & dosage</subject><subject>Selenium - pharmacology</subject><subject>Testes</subject><subject>Testis - drug effects</subject><subject>Testis - metabolism</subject><subject>Toxicity</subject><subject>Yeast</subject><subject>Yeasts</subject><issn>0163-4984</issn><issn>1559-0720</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kc9u1DAQxi0EokvhBTggS1wb6rHjJjmW8qcrtV1ElwMny3YmW5fELraDuu_Cw-J2C71xsEb298038vwIeQ3sHTDWHCbgDKBi0JXTclbJJ2QBUpZrw9lTsmBwJKq6a-s98iKla8ag4Z14TvYECN4Arxfk9yWO6N08VV-dvaLfUadMz112G50x0eNxnpwv6jn2rrz0dI0pOzuPOtJ1uHXW5S01W_p-DPaH8xu6unW9zu4X0sscMaUDuvRXzpTEIl6s6JcY-tlmF_wB1b6nH1zKczR36jJ4Z-lpmDCkrJNLL8mzQY8JXz3UffLt08f1yWl1tvq8PDk-q6xoZK7sUBbBpLGmNjhYobkxtsfOQqdbwVvk0GptOgPDgGCxkQiDBAA92J4xI_bJ213uTQw_5_JBdR3m6MtIxfkRq7tOdm1x8Z3LxpBSxEHdRDfpuFXA1B0QtQOiChB1D0TJ0vTmIXo2E_b_Wv4SKAaxM6Qi-Q3Gx9n_if0D01eaGw</recordid><startdate>20200501</startdate><enddate>20200501</enddate><creator>Cao, Changyu</creator><creator>Zhang, Haoji</creator><creator>Wang, Kai</creator><creator>Li, Xinran</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QH</scope><scope>7QP</scope><scope>7TN</scope><scope>7U7</scope><scope>7UA</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>BKSAR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>F1W</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H97</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>L.G</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PCBAR</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><orcidid>https://orcid.org/0000-0002-1035-852X</orcidid></search><sort><creationdate>20200501</creationdate><title>Selenium-Rich Yeast Mitigates Aluminum-Mediated Testicular Toxicity by Blocking Oxidative Stress, Inhibiting NO Production, and Disturbing Ionic Homeostasis</title><author>Cao, Changyu ; Zhang, Haoji ; Wang, Kai ; Li, Xinran</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c375t-cf12005bcb4befc3a2bbcde9c19a8328e218aab9b1ffe1ce75e1f5111afcd00b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Aluminium</topic><topic>Aluminum</topic><topic>Aluminum - 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Dietary supplementation with selenium-rich yeast (SeY) has been shown to prevent a variety of pathologic conditions. In the present study, the potential protect role of SeY on Al-induced testicular toxicity was evaluated, and the possible underlying mechanisms were discussed. Mice were treated with SeY (0.1 mg/kg) and/or Al (10 mg/kg) by oral gavage for 4 weeks. Histopathologic changes were observed in the testes of Al-treated mice. Oxidative stress, ionic disturbances, and the generation of NO systems are believed to have resulted in the observed pathology. Interestingly, SeY supplementation significantly inhibited the Al-induced histopathological and molecular changes and restored these indicators to levels observed in the control animals. These results suggest that SeY exerts a testis-protective effect against Al-induced toxicity through the reduction of oxidative stress, NO production, and the maintenance of ionic homeostasis.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>31327124</pmid><doi>10.1007/s12011-019-01820-5</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-1035-852X</orcidid></addata></record> |
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| subjects | Aluminium Aluminum Aluminum - toxicity Animals Biochemistry Biological stress Biomedical and Life Sciences Biotechnology Dietary supplements Histopathology Homeostasis Homeostasis - drug effects Life Sciences Male Mice Mice, Inbred Strains Nitric Oxide - antagonists & inhibitors Nitric Oxide - biosynthesis Nutrition Oncology Oxidative stress Oxidative Stress - drug effects Pathology Reproductive system Saccharomyces cerevisiae - chemistry Selenium Selenium - administration & dosage Selenium - pharmacology Testes Testis - drug effects Testis - metabolism Toxicity Yeast Yeasts |
| title | Selenium-Rich Yeast Mitigates Aluminum-Mediated Testicular Toxicity by Blocking Oxidative Stress, Inhibiting NO Production, and Disturbing Ionic Homeostasis |
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