Bone microstructure of mice after prolonged taurine treatment
Taurine, a sulphur - containing amino acid, has been termed a functional nutrient. Its synthetic form is a common ingredient in supplements and energy drinks. There is no information concerning taurine impact on bone microstructure after prolonged supplemental use. Also, differences in bone paramete...
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| Veröffentlicht in: | Physiological research 2019-06, Vol.68 (3), p.519-523 |
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| creator | Martiniakova, M Sarocka, A Babosova, R Galbavy, D Kapusta, E Goc, Z Formicki, G Omelka, R |
| description | Taurine, a sulphur - containing amino acid, has been termed a functional nutrient. Its synthetic form is a common ingredient in supplements and energy drinks. There is no information concerning taurine impact on bone microstructure after prolonged supplemental use. Also, differences in bone parameters of mice following taurine exposure are unknown. In this study, a detailed microstructure of compact and trabecular bone tissues of mice subchronically exposed to taurine was determined. Animals (n=12) were segregated into three groups: E1 group - mice received 20 mg/kg b.w. of taurine per day during 8 weeks; E2 group - mice were fed by taurine at a dose of 40 mg/kg b.w. for 8 weeks and a control (C) group. Decreased density of secondary osteons, increased sizes of primary osteon's vascular canals (P |
| doi_str_mv | 10.33549/physiolres.934139 |
| format | Article |
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Its synthetic form is a common ingredient in supplements and energy drinks. There is no information concerning taurine impact on bone microstructure after prolonged supplemental use. Also, differences in bone parameters of mice following taurine exposure are unknown. In this study, a detailed microstructure of compact and trabecular bone tissues of mice subchronically exposed to taurine was determined. Animals (n=12) were segregated into three groups: E1 group - mice received 20 mg/kg b.w. of taurine per day during 8 weeks; E2 group - mice were fed by taurine at a dose of 40 mg/kg b.w. for 8 weeks and a control (C) group. Decreased density of secondary osteons, increased sizes of primary osteon's vascular canals (P<0.05) were observed in taurine - treated animals. Cortical bone thickness, trabecular thickness were decreased (P<0.05) in E1 group, and relative volume of trabecular bone was lower (P<0.05) in E2 group as compared to C group. According to our results, prolonged taurine exposure at the doses used in this study can negatively affect both compact and trabecular bone tissues microstructure.</description><identifier>ISSN: 0862-8408</identifier><identifier>EISSN: 1802-9973</identifier><identifier>DOI: 10.33549/physiolres.934139</identifier><identifier>PMID: 31301731</identifier><language>eng</language><publisher>Czech Republic: Institute of Physiology</publisher><subject>Alcohol ; Amino acids ; Animals ; Beverages ; Blood pressure ; Bone density ; Bone Density - drug effects ; Bone Density - physiology ; Bones ; Caffeine ; Cancellous bone ; Cortical bone ; Cortical Bone - cytology ; Cortical Bone - drug effects ; Cortical Bone - physiology ; Dietary supplements ; Drug Administration Schedule ; Energy drinks ; Femur - drug effects ; Femur - pathology ; Femur - physiology ; Males ; Metabolism ; Mice ; Osteons ; Random Allocation ; Sulfur ; Taurine ; Taurine - administration & dosage ; Taurine - toxicity</subject><ispartof>Physiological research, 2019-06, Vol.68 (3), p.519-523</ispartof><rights>Copyright Institute of Physiology 2019</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c408t-a71597db0a71d52c96ed503615a686558cfec78b9eca5b80070bd99d0f4607883</citedby><cites>FETCH-LOGICAL-c408t-a71597db0a71d52c96ed503615a686558cfec78b9eca5b80070bd99d0f4607883</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,864,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31301731$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Martiniakova, M</creatorcontrib><creatorcontrib>Sarocka, A</creatorcontrib><creatorcontrib>Babosova, R</creatorcontrib><creatorcontrib>Galbavy, D</creatorcontrib><creatorcontrib>Kapusta, E</creatorcontrib><creatorcontrib>Goc, Z</creatorcontrib><creatorcontrib>Formicki, G</creatorcontrib><creatorcontrib>Omelka, R</creatorcontrib><title>Bone microstructure of mice after prolonged taurine treatment</title><title>Physiological research</title><addtitle>Physiol Res</addtitle><description>Taurine, a sulphur - containing amino acid, has been termed a functional nutrient. Its synthetic form is a common ingredient in supplements and energy drinks. There is no information concerning taurine impact on bone microstructure after prolonged supplemental use. Also, differences in bone parameters of mice following taurine exposure are unknown. In this study, a detailed microstructure of compact and trabecular bone tissues of mice subchronically exposed to taurine was determined. Animals (n=12) were segregated into three groups: E1 group - mice received 20 mg/kg b.w. of taurine per day during 8 weeks; E2 group - mice were fed by taurine at a dose of 40 mg/kg b.w. for 8 weeks and a control (C) group. Decreased density of secondary osteons, increased sizes of primary osteon's vascular canals (P<0.05) were observed in taurine - treated animals. Cortical bone thickness, trabecular thickness were decreased (P<0.05) in E1 group, and relative volume of trabecular bone was lower (P<0.05) in E2 group as compared to C group. According to our results, prolonged taurine exposure at the doses used in this study can negatively affect both compact and trabecular bone tissues microstructure.</description><subject>Alcohol</subject><subject>Amino acids</subject><subject>Animals</subject><subject>Beverages</subject><subject>Blood pressure</subject><subject>Bone density</subject><subject>Bone Density - drug effects</subject><subject>Bone Density - physiology</subject><subject>Bones</subject><subject>Caffeine</subject><subject>Cancellous bone</subject><subject>Cortical bone</subject><subject>Cortical Bone - cytology</subject><subject>Cortical Bone - drug effects</subject><subject>Cortical Bone - physiology</subject><subject>Dietary supplements</subject><subject>Drug Administration Schedule</subject><subject>Energy drinks</subject><subject>Femur - drug effects</subject><subject>Femur - pathology</subject><subject>Femur - physiology</subject><subject>Males</subject><subject>Metabolism</subject><subject>Mice</subject><subject>Osteons</subject><subject>Random Allocation</subject><subject>Sulfur</subject><subject>Taurine</subject><subject>Taurine - 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drug effects</topic><topic>Bone Density - physiology</topic><topic>Bones</topic><topic>Caffeine</topic><topic>Cancellous bone</topic><topic>Cortical bone</topic><topic>Cortical Bone - cytology</topic><topic>Cortical Bone - drug effects</topic><topic>Cortical Bone - physiology</topic><topic>Dietary supplements</topic><topic>Drug Administration Schedule</topic><topic>Energy drinks</topic><topic>Femur - drug effects</topic><topic>Femur - pathology</topic><topic>Femur - physiology</topic><topic>Males</topic><topic>Metabolism</topic><topic>Mice</topic><topic>Osteons</topic><topic>Random Allocation</topic><topic>Sulfur</topic><topic>Taurine</topic><topic>Taurine - administration & dosage</topic><topic>Taurine - toxicity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Martiniakova, M</creatorcontrib><creatorcontrib>Sarocka, A</creatorcontrib><creatorcontrib>Babosova, R</creatorcontrib><creatorcontrib>Galbavy, D</creatorcontrib><creatorcontrib>Kapusta, E</creatorcontrib><creatorcontrib>Goc, Z</creatorcontrib><creatorcontrib>Formicki, G</creatorcontrib><creatorcontrib>Omelka, R</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Docstoc</collection><collection>University Readers</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>East Europe, Central Europe Database</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><jtitle>Physiological research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Martiniakova, M</au><au>Sarocka, A</au><au>Babosova, R</au><au>Galbavy, D</au><au>Kapusta, E</au><au>Goc, Z</au><au>Formicki, G</au><au>Omelka, R</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Bone microstructure of mice after prolonged taurine treatment</atitle><jtitle>Physiological research</jtitle><addtitle>Physiol Res</addtitle><date>2019-06-30</date><risdate>2019</risdate><volume>68</volume><issue>3</issue><spage>519</spage><epage>523</epage><pages>519-523</pages><issn>0862-8408</issn><eissn>1802-9973</eissn><abstract>Taurine, a sulphur - containing amino acid, has been termed a functional nutrient. Its synthetic form is a common ingredient in supplements and energy drinks. There is no information concerning taurine impact on bone microstructure after prolonged supplemental use. Also, differences in bone parameters of mice following taurine exposure are unknown. In this study, a detailed microstructure of compact and trabecular bone tissues of mice subchronically exposed to taurine was determined. Animals (n=12) were segregated into three groups: E1 group - mice received 20 mg/kg b.w. of taurine per day during 8 weeks; E2 group - mice were fed by taurine at a dose of 40 mg/kg b.w. for 8 weeks and a control (C) group. Decreased density of secondary osteons, increased sizes of primary osteon's vascular canals (P<0.05) were observed in taurine - treated animals. Cortical bone thickness, trabecular thickness were decreased (P<0.05) in E1 group, and relative volume of trabecular bone was lower (P<0.05) in E2 group as compared to C group. According to our results, prolonged taurine exposure at the doses used in this study can negatively affect both compact and trabecular bone tissues microstructure.</abstract><cop>Czech Republic</cop><pub>Institute of Physiology</pub><pmid>31301731</pmid><doi>10.33549/physiolres.934139</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Physiological research, 2019-06, Vol.68 (3), p.519-523 |
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| subjects | Alcohol Amino acids Animals Beverages Blood pressure Bone density Bone Density - drug effects Bone Density - physiology Bones Caffeine Cancellous bone Cortical bone Cortical Bone - cytology Cortical Bone - drug effects Cortical Bone - physiology Dietary supplements Drug Administration Schedule Energy drinks Femur - drug effects Femur - pathology Femur - physiology Males Metabolism Mice Osteons Random Allocation Sulfur Taurine Taurine - administration & dosage Taurine - toxicity |
| title | Bone microstructure of mice after prolonged taurine treatment |
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