Metabolic and renal effects of dietary advanced glycation end products in pregnant rats - a pilot study
Thermally processed food contains advanced glycation end products (AGEs) including N(epsilon)-(carboxymethyl)lysine (CML). Higher AGEs or circulating CML were shown to be associated with pregnancy complications such as preeclampsia and gestational diabetes. It is unclear whether this association is...
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| Veröffentlicht in: | Physiological research 2019-06, Vol.68 (3), p.467-479 |
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| creator | Janšáková, K Lengyelová, E Pribulová, N Somoza, V Celec, P Šebeková, K Ostatníková, D Tóthová, Ľ |
| description | Thermally processed food contains advanced glycation end products (AGEs) including N(epsilon)-(carboxymethyl)lysine (CML). Higher AGEs or circulating CML were shown to be associated with pregnancy complications such as preeclampsia and gestational diabetes. It is unclear whether this association is causal. The aim of our study was to analyze the effects of dietary CML and CML-containing thermally processed food on metabolism in pregnant rats. Animals were fed with standard or with AGE-rich diet from gestation day 1. Third group received standard diet and CML via gavage. On gestation day 18, blood pressure was measured, urine and blood were collected and the oral glucose tolerance test was performed. Plasma AGEs were slightly higher in pregnant rats fed with the AGE-rich diet (p=0.09). A non-significant trend towards higher CML in plasma was found in the CML group (p=0.06). No significant differences between groups were revealed in glucose metabolism or markers of renal functions like proteinuria and creatinine clearance. In conclusion, this study does not support the hypothesis that dietary AGEs such as CML might induce harmful metabolic changes or contribute to the pathogenesis of pregnancy complications. The short duration of the rodent gestation warrants further studies analyzing long-term effects of AGEs/CML in preconception nutrition. |
| doi_str_mv | 10.33549/physiolres.934102 |
| format | Article |
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Higher AGEs or circulating CML were shown to be associated with pregnancy complications such as preeclampsia and gestational diabetes. It is unclear whether this association is causal. The aim of our study was to analyze the effects of dietary CML and CML-containing thermally processed food on metabolism in pregnant rats. Animals were fed with standard or with AGE-rich diet from gestation day 1. Third group received standard diet and CML via gavage. On gestation day 18, blood pressure was measured, urine and blood were collected and the oral glucose tolerance test was performed. Plasma AGEs were slightly higher in pregnant rats fed with the AGE-rich diet (p=0.09). A non-significant trend towards higher CML in plasma was found in the CML group (p=0.06). No significant differences between groups were revealed in glucose metabolism or markers of renal functions like proteinuria and creatinine clearance. In conclusion, this study does not support the hypothesis that dietary AGEs such as CML might induce harmful metabolic changes or contribute to the pathogenesis of pregnancy complications. The short duration of the rodent gestation warrants further studies analyzing long-term effects of AGEs/CML in preconception nutrition.</description><identifier>ISSN: 0862-8408</identifier><identifier>EISSN: 1802-9973</identifier><identifier>DOI: 10.33549/physiolres.934102</identifier><identifier>PMID: 30904014</identifier><language>eng</language><publisher>Czech Republic: Institute of Physiology</publisher><subject>Advanced glycosylation end products ; Age ; Animals ; Blood pressure ; Creatinine ; Diabetes ; Diabetes mellitus ; Diabetes, Gestational - chemically induced ; Diabetes, Gestational - metabolism ; Diet ; Diet - adverse effects ; Diet - trends ; Experiments ; Female ; Food ; Food processing ; Gestation ; Glucose metabolism ; Glucose tolerance ; Glycation End Products, Advanced - administration & dosage ; Glycation End Products, Advanced - adverse effects ; Glycosylation ; Inflammation ; Insulin resistance ; Kidney - drug effects ; Kidney - metabolism ; Long-term effects ; Lysine ; Lysine - administration & dosage ; Lysine - adverse effects ; Lysine - analogs & derivatives ; Metabolism ; Nutrition research ; Pathogenesis ; Pilot Projects ; Plasma ; Pre-eclampsia ; Preeclampsia ; Pregnancy ; Pregnancy complications ; Processed foods ; Proteinuria ; Rats ; Rats, Wistar ; Urine</subject><ispartof>Physiological research, 2019-06, Vol.68 (3), p.467-479</ispartof><rights>Copyright Institute of Physiology 2019</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c342t-ca022c58c0c384e130284f2e7b157fe997f9905813dae95443dcf5dd474eceef3</citedby><cites>FETCH-LOGICAL-c342t-ca022c58c0c384e130284f2e7b157fe997f9905813dae95443dcf5dd474eceef3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,861,27905,27906</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30904014$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Janšáková, K</creatorcontrib><creatorcontrib>Lengyelová, E</creatorcontrib><creatorcontrib>Pribulová, N</creatorcontrib><creatorcontrib>Somoza, V</creatorcontrib><creatorcontrib>Celec, P</creatorcontrib><creatorcontrib>Šebeková, K</creatorcontrib><creatorcontrib>Ostatníková, D</creatorcontrib><creatorcontrib>Tóthová, Ľ</creatorcontrib><title>Metabolic and renal effects of dietary advanced glycation end products in pregnant rats - a pilot study</title><title>Physiological research</title><addtitle>Physiol Res</addtitle><description>Thermally processed food contains advanced glycation end products (AGEs) including N(epsilon)-(carboxymethyl)lysine (CML). Higher AGEs or circulating CML were shown to be associated with pregnancy complications such as preeclampsia and gestational diabetes. It is unclear whether this association is causal. The aim of our study was to analyze the effects of dietary CML and CML-containing thermally processed food on metabolism in pregnant rats. Animals were fed with standard or with AGE-rich diet from gestation day 1. Third group received standard diet and CML via gavage. On gestation day 18, blood pressure was measured, urine and blood were collected and the oral glucose tolerance test was performed. Plasma AGEs were slightly higher in pregnant rats fed with the AGE-rich diet (p=0.09). A non-significant trend towards higher CML in plasma was found in the CML group (p=0.06). No significant differences between groups were revealed in glucose metabolism or markers of renal functions like proteinuria and creatinine clearance. In conclusion, this study does not support the hypothesis that dietary AGEs such as CML might induce harmful metabolic changes or contribute to the pathogenesis of pregnancy complications. The short duration of the rodent gestation warrants further studies analyzing long-term effects of AGEs/CML in preconception nutrition.</description><subject>Advanced glycosylation end products</subject><subject>Age</subject><subject>Animals</subject><subject>Blood pressure</subject><subject>Creatinine</subject><subject>Diabetes</subject><subject>Diabetes mellitus</subject><subject>Diabetes, Gestational - chemically induced</subject><subject>Diabetes, Gestational - metabolism</subject><subject>Diet</subject><subject>Diet - adverse effects</subject><subject>Diet - trends</subject><subject>Experiments</subject><subject>Female</subject><subject>Food</subject><subject>Food processing</subject><subject>Gestation</subject><subject>Glucose metabolism</subject><subject>Glucose tolerance</subject><subject>Glycation End Products, Advanced - administration & dosage</subject><subject>Glycation End Products, Advanced - adverse effects</subject><subject>Glycosylation</subject><subject>Inflammation</subject><subject>Insulin resistance</subject><subject>Kidney - drug effects</subject><subject>Kidney - metabolism</subject><subject>Long-term effects</subject><subject>Lysine</subject><subject>Lysine - administration & dosage</subject><subject>Lysine - adverse effects</subject><subject>Lysine - analogs & derivatives</subject><subject>Metabolism</subject><subject>Nutrition research</subject><subject>Pathogenesis</subject><subject>Pilot Projects</subject><subject>Plasma</subject><subject>Pre-eclampsia</subject><subject>Preeclampsia</subject><subject>Pregnancy</subject><subject>Pregnancy complications</subject><subject>Processed foods</subject><subject>Proteinuria</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Urine</subject><issn>0862-8408</issn><issn>1802-9973</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNpFUMtOwzAQtBCIlsIPcECWOKesH2mcI6p4SSAucI5ce11SpXGwE6T8PS4toD3sandmtDOEXDKYC5HL8qb7GGPtm4BxXgrJgB-RKVPAs7IsxDGZglrwTElQE3IW4waAF1CIUzIRUIIEJqdk_YK9XvmmNlS3lgZsdUPROTR9pN5RW6d7GKm2X7o1aOm6GY3ua99STPgueDvsoHWbZly3uu1p0GmRUU27uvE9jf1gx3Ny4nQT8eLQZ-T9_u5t-Zg9vz48LW-fMyMk7zOjgXOTKwNGKIlMAFfScSxWLC8cJl-uLCFXTFiNZS6lsMbl1spCokF0Ykau97rps88BY19t_BCSqVhxvgDJxK5mhO9RJvgYA7qqC_U2-awYVD_ZVv_ZVvtsE-nqID2stmj_KL9him_GN3jA</recordid><startdate>20190630</startdate><enddate>20190630</enddate><creator>Janšáková, K</creator><creator>Lengyelová, E</creator><creator>Pribulová, N</creator><creator>Somoza, V</creator><creator>Celec, P</creator><creator>Šebeková, K</creator><creator>Ostatníková, D</creator><creator>Tóthová, Ľ</creator><general>Institute of Physiology</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>4T-</scope><scope>4U-</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>BYOGL</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope></search><sort><creationdate>20190630</creationdate><title>Metabolic and renal effects of dietary advanced glycation end products in pregnant rats - a pilot study</title><author>Janšáková, K ; Lengyelová, E ; Pribulová, N ; Somoza, V ; Celec, P ; Šebeková, K ; Ostatníková, D ; Tóthová, Ľ</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c342t-ca022c58c0c384e130284f2e7b157fe997f9905813dae95443dcf5dd474eceef3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Advanced glycosylation end products</topic><topic>Age</topic><topic>Animals</topic><topic>Blood pressure</topic><topic>Creatinine</topic><topic>Diabetes</topic><topic>Diabetes mellitus</topic><topic>Diabetes, Gestational - chemically induced</topic><topic>Diabetes, Gestational - metabolism</topic><topic>Diet</topic><topic>Diet - adverse effects</topic><topic>Diet - trends</topic><topic>Experiments</topic><topic>Female</topic><topic>Food</topic><topic>Food processing</topic><topic>Gestation</topic><topic>Glucose metabolism</topic><topic>Glucose tolerance</topic><topic>Glycation End Products, Advanced - administration & dosage</topic><topic>Glycation End Products, Advanced - adverse effects</topic><topic>Glycosylation</topic><topic>Inflammation</topic><topic>Insulin resistance</topic><topic>Kidney - drug effects</topic><topic>Kidney - metabolism</topic><topic>Long-term effects</topic><topic>Lysine</topic><topic>Lysine - administration & dosage</topic><topic>Lysine - adverse effects</topic><topic>Lysine - analogs & derivatives</topic><topic>Metabolism</topic><topic>Nutrition research</topic><topic>Pathogenesis</topic><topic>Pilot Projects</topic><topic>Plasma</topic><topic>Pre-eclampsia</topic><topic>Preeclampsia</topic><topic>Pregnancy</topic><topic>Pregnancy complications</topic><topic>Processed foods</topic><topic>Proteinuria</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Urine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Janšáková, K</creatorcontrib><creatorcontrib>Lengyelová, E</creatorcontrib><creatorcontrib>Pribulová, N</creatorcontrib><creatorcontrib>Somoza, V</creatorcontrib><creatorcontrib>Celec, P</creatorcontrib><creatorcontrib>Šebeková, K</creatorcontrib><creatorcontrib>Ostatníková, D</creatorcontrib><creatorcontrib>Tóthová, Ľ</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Docstoc</collection><collection>University Readers</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>East Europe, Central Europe Database</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><jtitle>Physiological research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Janšáková, K</au><au>Lengyelová, E</au><au>Pribulová, N</au><au>Somoza, V</au><au>Celec, P</au><au>Šebeková, K</au><au>Ostatníková, D</au><au>Tóthová, Ľ</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Metabolic and renal effects of dietary advanced glycation end products in pregnant rats - a pilot study</atitle><jtitle>Physiological research</jtitle><addtitle>Physiol Res</addtitle><date>2019-06-30</date><risdate>2019</risdate><volume>68</volume><issue>3</issue><spage>467</spage><epage>479</epage><pages>467-479</pages><issn>0862-8408</issn><eissn>1802-9973</eissn><abstract>Thermally processed food contains advanced glycation end products (AGEs) including N(epsilon)-(carboxymethyl)lysine (CML). Higher AGEs or circulating CML were shown to be associated with pregnancy complications such as preeclampsia and gestational diabetes. It is unclear whether this association is causal. The aim of our study was to analyze the effects of dietary CML and CML-containing thermally processed food on metabolism in pregnant rats. Animals were fed with standard or with AGE-rich diet from gestation day 1. Third group received standard diet and CML via gavage. On gestation day 18, blood pressure was measured, urine and blood were collected and the oral glucose tolerance test was performed. Plasma AGEs were slightly higher in pregnant rats fed with the AGE-rich diet (p=0.09). A non-significant trend towards higher CML in plasma was found in the CML group (p=0.06). No significant differences between groups were revealed in glucose metabolism or markers of renal functions like proteinuria and creatinine clearance. In conclusion, this study does not support the hypothesis that dietary AGEs such as CML might induce harmful metabolic changes or contribute to the pathogenesis of pregnancy complications. The short duration of the rodent gestation warrants further studies analyzing long-term effects of AGEs/CML in preconception nutrition.</abstract><cop>Czech Republic</cop><pub>Institute of Physiology</pub><pmid>30904014</pmid><doi>10.33549/physiolres.934102</doi><tpages>13</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Advanced glycosylation end products Age Animals Blood pressure Creatinine Diabetes Diabetes mellitus Diabetes, Gestational - chemically induced Diabetes, Gestational - metabolism Diet Diet - adverse effects Diet - trends Experiments Female Food Food processing Gestation Glucose metabolism Glucose tolerance Glycation End Products, Advanced - administration & dosage Glycation End Products, Advanced - adverse effects Glycosylation Inflammation Insulin resistance Kidney - drug effects Kidney - metabolism Long-term effects Lysine Lysine - administration & dosage Lysine - adverse effects Lysine - analogs & derivatives Metabolism Nutrition research Pathogenesis Pilot Projects Plasma Pre-eclampsia Preeclampsia Pregnancy Pregnancy complications Processed foods Proteinuria Rats Rats, Wistar Urine |
| title | Metabolic and renal effects of dietary advanced glycation end products in pregnant rats - a pilot study |
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