In-Situ Measurement of Vitamin C Content in Commercial Tablet Products by Terahertz Time-Domain
Terahertz time-domain spectroscopy (THz-TDS) was applied to investigate the feasibility of in-situ measuring vitamin C content in commercial tablet products without any pretreatments. Characteristic absorption peaks of vitamin C were analyzed with quantum mechanical calculation to reveal the molecul...
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| Veröffentlicht in: | Journal of infrared, millimeter and terahertz waves millimeter and terahertz waves, 2018-04, Vol.39 (4), p.367-377 |
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| container_end_page | 377 |
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| container_issue | 4 |
| container_start_page | 367 |
| container_title | Journal of infrared, millimeter and terahertz waves |
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| creator | Kang, JuHee Song, Jeonghun Jung, Tae Sub Kwak, Kyungwon Chun, Hyang Sook |
| description | Terahertz time-domain spectroscopy (THz-TDS) was applied to investigate the feasibility of in-situ measuring vitamin C content in commercial tablet products without any pretreatments. Characteristic absorption peaks of vitamin C were analyzed with quantum mechanical calculation to reveal the molecular origin of them. The peak appearing at 1.08 THz was then selected and tested for its suitability as a fingerprint signal for analyzing the vitamin C content in dietary supplement tablets. There are a couple of factors influencing THz absorbance other than concentration. Among those, the effects of tablet thickness and types of excipients in the tablet products were found to be significant, and were corrected with the calibration curve to determine vitamin C concentration in tablet forms. Furthermore, commercial tablet products in the market were analyzed using THz-TDS and the measured vitamin C contents were in good agreement with those determined using a reference method (high-performance liquid chromatography). Thus, our results suggest that THz-TDS can be used for the in-situ analysis of vitamin C in commercial tablet products. |
| doi_str_mv | 10.1007/s10762-018-0467-5 |
| format | Article |
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Characteristic absorption peaks of vitamin C were analyzed with quantum mechanical calculation to reveal the molecular origin of them. The peak appearing at 1.08 THz was then selected and tested for its suitability as a fingerprint signal for analyzing the vitamin C content in dietary supplement tablets. There are a couple of factors influencing THz absorbance other than concentration. Among those, the effects of tablet thickness and types of excipients in the tablet products were found to be significant, and were corrected with the calibration curve to determine vitamin C concentration in tablet forms. Furthermore, commercial tablet products in the market were analyzed using THz-TDS and the measured vitamin C contents were in good agreement with those determined using a reference method (high-performance liquid chromatography). Thus, our results suggest that THz-TDS can be used for the in-situ analysis of vitamin C in commercial tablet products.</description><identifier>ISSN: 1866-6892</identifier><identifier>EISSN: 1866-6906</identifier><identifier>DOI: 10.1007/s10762-018-0467-5</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Ascorbic acid ; Classical Electrodynamics ; Electrical Engineering ; Electronics and Microelectronics ; Engineering ; Glucose ; High performance liquid chromatography ; Instrumentation ; Quantum mechanics ; Tablets ; Time domain analysis ; Vitamin C</subject><ispartof>Journal of infrared, millimeter and terahertz waves, 2018-04, Vol.39 (4), p.367-377</ispartof><rights>Springer Science+Business Media, LLC, part of Springer Nature 2018</rights><rights>Copyright Springer Science & Business Media 2018</rights><rights>Journal of Infrared, Millimeter, and Terahertz Waves is a copyright of Springer, (2018). 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Characteristic absorption peaks of vitamin C were analyzed with quantum mechanical calculation to reveal the molecular origin of them. The peak appearing at 1.08 THz was then selected and tested for its suitability as a fingerprint signal for analyzing the vitamin C content in dietary supplement tablets. There are a couple of factors influencing THz absorbance other than concentration. Among those, the effects of tablet thickness and types of excipients in the tablet products were found to be significant, and were corrected with the calibration curve to determine vitamin C concentration in tablet forms. Furthermore, commercial tablet products in the market were analyzed using THz-TDS and the measured vitamin C contents were in good agreement with those determined using a reference method (high-performance liquid chromatography). Thus, our results suggest that THz-TDS can be used for the in-situ analysis of vitamin C in commercial tablet products.</description><subject>Ascorbic acid</subject><subject>Classical Electrodynamics</subject><subject>Electrical Engineering</subject><subject>Electronics and Microelectronics</subject><subject>Engineering</subject><subject>Glucose</subject><subject>High performance liquid chromatography</subject><subject>Instrumentation</subject><subject>Quantum mechanics</subject><subject>Tablets</subject><subject>Time domain analysis</subject><subject>Vitamin C</subject><issn>1866-6892</issn><issn>1866-6906</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNp9kMtKxDAUhoMoOI4-gLuA62huzWUp9TagKFjdhjRNtcO0HZN0MT69LVVc6epc-P5z4APglOBzgrG8iARLQREmCmEuJMr2wIIoIZDQWOz_9ErTQ3AU4xpjwbkWC2BWHXpu0gAfvI1D8K3vEuxr-Nok2zYdzGHed2laTkPftj64xm5gYcuNT_Ap9NXgUoTlDhY-2Hcf0icsmtajq761TXcMDmq7if7kuy7By811kd-h-8fbVX55jxzjPCGvKyazmvJaOFxSUbqMMatpJUjNFHOCKeJkqWrLPMdKeVt567SQyjJZY8mW4Gy-uw39x-BjMut-CN340lCaaSkpVfRfCmMtOJOajBSZKRf6GIOvzTY0rQ07Q7CZbJvZthltm8m2ycYMnTNxZLs3H34v_x36AqNrgQw</recordid><startdate>20180401</startdate><enddate>20180401</enddate><creator>Kang, JuHee</creator><creator>Song, Jeonghun</creator><creator>Jung, Tae Sub</creator><creator>Kwak, Kyungwon</creator><creator>Chun, Hyang Sook</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope><scope>8FE</scope><scope>8FG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>HCIFZ</scope><scope>P5Z</scope><scope>P62</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><orcidid>https://orcid.org/0000-0003-1680-0996</orcidid></search><sort><creationdate>20180401</creationdate><title>In-Situ Measurement of Vitamin C Content in Commercial Tablet Products by Terahertz Time-Domain</title><author>Kang, JuHee ; 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Characteristic absorption peaks of vitamin C were analyzed with quantum mechanical calculation to reveal the molecular origin of them. The peak appearing at 1.08 THz was then selected and tested for its suitability as a fingerprint signal for analyzing the vitamin C content in dietary supplement tablets. There are a couple of factors influencing THz absorbance other than concentration. Among those, the effects of tablet thickness and types of excipients in the tablet products were found to be significant, and were corrected with the calibration curve to determine vitamin C concentration in tablet forms. Furthermore, commercial tablet products in the market were analyzed using THz-TDS and the measured vitamin C contents were in good agreement with those determined using a reference method (high-performance liquid chromatography). 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| subjects | Ascorbic acid Classical Electrodynamics Electrical Engineering Electronics and Microelectronics Engineering Glucose High performance liquid chromatography Instrumentation Quantum mechanics Tablets Time domain analysis Vitamin C |
| title | In-Situ Measurement of Vitamin C Content in Commercial Tablet Products by Terahertz Time-Domain |
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