Synthesis and characterization of gold-conjugated Backhousia citriodora nanoparticles and their anticancer activity against MCF-7 breast and HepG2 liver cancer cell lines
Environmentally benign-synthesized gold nanoparticles (Au-NPs) have received substantial attention owing to their biomedical applications, particularly in cancer therapy. In the current study, Backhousia citriodora ( B. citriodora ) leaf extract was applied as a reducing agent for one-pot synthesis...
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| Veröffentlicht in: | Journal of materials science 2018-03, Vol.53 (5), p.3106-3118 |
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| creator | Khandanlou, Roshanak Murthy, Vinuthaa Saranath, Dhananjaya Damani, Hetal |
| description | Environmentally benign-synthesized gold nanoparticles (Au-NPs) have received substantial attention owing to their biomedical applications, particularly in cancer therapy. In the current study,
Backhousia citriodora
(
B. citriodora
) leaf extract was applied as a reducing agent for one-pot synthesis of controlled size Au-NPs. The effect of various parameters such as reaction time, pH, and
B. citriodora
leaf boiling time on the synthesis of Au-NPs was studied. The characterization of the Au-NPs synthesized at 15.0-min incubation time showed colour change because of the surface plasma resonance band around 530.0 nm. TEM photographs showed spherical morphologies with an average size of 8.40 ± 0.084 nm and zeta potential value was − 29.74 mV, indicating stability of the nanoparticles. The biomedical properties of Au-NPs and
B. citriodora
leaf extract showed strong DPPH radical scavenging. The in vitro anticancer activity determined using MTT assay exhibited that Au-NPs showed a significant dose-dependent reduction in the viability of the MCF-7 breast cancer cell line and the HepG2 liver cancer cell line with IC
50
values of 116.65 and 108.21 µg, respectively. |
| doi_str_mv | 10.1007/s10853-017-1756-4 |
| format | Article |
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Backhousia citriodora
(
B. citriodora
) leaf extract was applied as a reducing agent for one-pot synthesis of controlled size Au-NPs. The effect of various parameters such as reaction time, pH, and
B. citriodora
leaf boiling time on the synthesis of Au-NPs was studied. The characterization of the Au-NPs synthesized at 15.0-min incubation time showed colour change because of the surface plasma resonance band around 530.0 nm. TEM photographs showed spherical morphologies with an average size of 8.40 ± 0.084 nm and zeta potential value was − 29.74 mV, indicating stability of the nanoparticles. The biomedical properties of Au-NPs and
B. citriodora
leaf extract showed strong DPPH radical scavenging. The in vitro anticancer activity determined using MTT assay exhibited that Au-NPs showed a significant dose-dependent reduction in the viability of the MCF-7 breast cancer cell line and the HepG2 liver cancer cell line with IC
50
values of 116.65 and 108.21 µg, respectively.</description><identifier>ISSN: 0022-2461</identifier><identifier>EISSN: 1573-4803</identifier><identifier>DOI: 10.1007/s10853-017-1756-4</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Anticancer properties ; Biomaterials ; Biomedical materials ; Breast cancer ; Cancer treatment ; Characterization and Evaluation of Materials ; Chemistry and Materials Science ; Classical Mechanics ; Crystallography and Scattering Methods ; Gold ; Health aspects ; Herbal medicine ; Liver ; Liver cancer ; Materials Science ; Morphology ; Nanoparticles ; Plasma resonance ; Polymer Sciences ; Reaction time ; Reducing agents ; Scavenging ; Solid Mechanics ; Viability ; Zeta potential</subject><ispartof>Journal of materials science, 2018-03, Vol.53 (5), p.3106-3118</ispartof><rights>Springer Science+Business Media, LLC 2017</rights><rights>COPYRIGHT 2018 Springer</rights><rights>Journal of Materials Science is a copyright of Springer, (2017). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c417t-41394f7ef53610bbcd3a0cc242a36b5b19dae56bc3f7c20bbb224786a86affe23</citedby><cites>FETCH-LOGICAL-c417t-41394f7ef53610bbcd3a0cc242a36b5b19dae56bc3f7c20bbb224786a86affe23</cites><orcidid>0000-0002-6147-730X ; 0000-0002-3828-2424 ; 0000-0002-3214-2420 ; 0000-0002-1396-9780</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10853-017-1756-4$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10853-017-1756-4$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids></links><search><creatorcontrib>Khandanlou, Roshanak</creatorcontrib><creatorcontrib>Murthy, Vinuthaa</creatorcontrib><creatorcontrib>Saranath, Dhananjaya</creatorcontrib><creatorcontrib>Damani, Hetal</creatorcontrib><title>Synthesis and characterization of gold-conjugated Backhousia citriodora nanoparticles and their anticancer activity against MCF-7 breast and HepG2 liver cancer cell lines</title><title>Journal of materials science</title><addtitle>J Mater Sci</addtitle><description>Environmentally benign-synthesized gold nanoparticles (Au-NPs) have received substantial attention owing to their biomedical applications, particularly in cancer therapy. In the current study,
Backhousia citriodora
(
B. citriodora
) leaf extract was applied as a reducing agent for one-pot synthesis of controlled size Au-NPs. The effect of various parameters such as reaction time, pH, and
B. citriodora
leaf boiling time on the synthesis of Au-NPs was studied. The characterization of the Au-NPs synthesized at 15.0-min incubation time showed colour change because of the surface plasma resonance band around 530.0 nm. TEM photographs showed spherical morphologies with an average size of 8.40 ± 0.084 nm and zeta potential value was − 29.74 mV, indicating stability of the nanoparticles. The biomedical properties of Au-NPs and
B. citriodora
leaf extract showed strong DPPH radical scavenging. The in vitro anticancer activity determined using MTT assay exhibited that Au-NPs showed a significant dose-dependent reduction in the viability of the MCF-7 breast cancer cell line and the HepG2 liver cancer cell line with IC
50
values of 116.65 and 108.21 µg, respectively.</description><subject>Anticancer properties</subject><subject>Biomaterials</subject><subject>Biomedical materials</subject><subject>Breast cancer</subject><subject>Cancer treatment</subject><subject>Characterization and Evaluation of Materials</subject><subject>Chemistry and Materials Science</subject><subject>Classical Mechanics</subject><subject>Crystallography and Scattering Methods</subject><subject>Gold</subject><subject>Health aspects</subject><subject>Herbal medicine</subject><subject>Liver</subject><subject>Liver cancer</subject><subject>Materials Science</subject><subject>Morphology</subject><subject>Nanoparticles</subject><subject>Plasma resonance</subject><subject>Polymer Sciences</subject><subject>Reaction time</subject><subject>Reducing agents</subject><subject>Scavenging</subject><subject>Solid Mechanics</subject><subject>Viability</subject><subject>Zeta potential</subject><issn>0022-2461</issn><issn>1573-4803</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNp1ks2KFDEUhQtRsB19AHcBVy4y5q8qVcuxcX5gZMDRdbiVSqrTVidtkhpsH8mnNE0NDA0OCeTm8p0TcjlV9Z6Sc0qI_JQoaWuOCZWYyrrB4kW1orXkWLSEv6xWhDCGmWjo6-pNSltCSC0ZXVV_7w8-b0xyCYEfkN5ABJ1NdH8gu-BRsGgM04B18Nt5hGwG9Bn0z02YkwOkXY4uDCEC8uDDHmJ2ejKLV7F1sVSlBV6bUursHlw-IBjB-ZTR1_UllqiPBsrlKLk2-yuGJvdQ6EeRNtNUOt6kt9UrC1My7x7Ps-rH5Zfv62t8e3d1s764xVpQmbGgvBNWGlvzhpK-1wMHojUTDHjT1z3tBjB102tupWYF6BkTsm2gbGsN42fVh8V3H8Ov2aSstmGOvjypGKu7hsuO0SdqhMko523IZXI7l7S6qGkrOtK2R-r8P1RZg9m5MlNjXemfCD6eCAqTze88wpySurn_dsrShdUxpBSNVfvodhAPihJ1TIVaUqFKKtQxFUoUDVs0qbB-NPHpc8-L_gEvJLtw</recordid><startdate>20180301</startdate><enddate>20180301</enddate><creator>Khandanlou, Roshanak</creator><creator>Murthy, Vinuthaa</creator><creator>Saranath, Dhananjaya</creator><creator>Damani, Hetal</creator><general>Springer US</general><general>Springer</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope><scope>ISR</scope><scope>8FE</scope><scope>8FG</scope><scope>ABJCF</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>HCIFZ</scope><scope>KB.</scope><scope>L6V</scope><scope>M7S</scope><scope>PDBOC</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><orcidid>https://orcid.org/0000-0002-6147-730X</orcidid><orcidid>https://orcid.org/0000-0002-3828-2424</orcidid><orcidid>https://orcid.org/0000-0002-3214-2420</orcidid><orcidid>https://orcid.org/0000-0002-1396-9780</orcidid></search><sort><creationdate>20180301</creationdate><title>Synthesis and characterization of gold-conjugated Backhousia citriodora nanoparticles and their anticancer activity against MCF-7 breast and HepG2 liver cancer cell lines</title><author>Khandanlou, Roshanak ; Murthy, Vinuthaa ; Saranath, Dhananjaya ; Damani, Hetal</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c417t-41394f7ef53610bbcd3a0cc242a36b5b19dae56bc3f7c20bbb224786a86affe23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Anticancer properties</topic><topic>Biomaterials</topic><topic>Biomedical materials</topic><topic>Breast cancer</topic><topic>Cancer treatment</topic><topic>Characterization and Evaluation of Materials</topic><topic>Chemistry and Materials Science</topic><topic>Classical Mechanics</topic><topic>Crystallography and Scattering Methods</topic><topic>Gold</topic><topic>Health aspects</topic><topic>Herbal medicine</topic><topic>Liver</topic><topic>Liver cancer</topic><topic>Materials Science</topic><topic>Morphology</topic><topic>Nanoparticles</topic><topic>Plasma resonance</topic><topic>Polymer Sciences</topic><topic>Reaction time</topic><topic>Reducing agents</topic><topic>Scavenging</topic><topic>Solid Mechanics</topic><topic>Viability</topic><topic>Zeta potential</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Khandanlou, Roshanak</creatorcontrib><creatorcontrib>Murthy, Vinuthaa</creatorcontrib><creatorcontrib>Saranath, Dhananjaya</creatorcontrib><creatorcontrib>Damani, Hetal</creatorcontrib><collection>CrossRef</collection><collection>Gale In Context: Science</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central</collection><collection>SciTech Premium Collection</collection><collection>Materials Science Database</collection><collection>ProQuest Engineering Collection</collection><collection>Engineering Database</collection><collection>Materials science collection</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Engineering Collection</collection><jtitle>Journal of materials science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Khandanlou, Roshanak</au><au>Murthy, Vinuthaa</au><au>Saranath, Dhananjaya</au><au>Damani, Hetal</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Synthesis and characterization of gold-conjugated Backhousia citriodora nanoparticles and their anticancer activity against MCF-7 breast and HepG2 liver cancer cell lines</atitle><jtitle>Journal of materials science</jtitle><stitle>J Mater Sci</stitle><date>2018-03-01</date><risdate>2018</risdate><volume>53</volume><issue>5</issue><spage>3106</spage><epage>3118</epage><pages>3106-3118</pages><issn>0022-2461</issn><eissn>1573-4803</eissn><abstract>Environmentally benign-synthesized gold nanoparticles (Au-NPs) have received substantial attention owing to their biomedical applications, particularly in cancer therapy. In the current study,
Backhousia citriodora
(
B. citriodora
) leaf extract was applied as a reducing agent for one-pot synthesis of controlled size Au-NPs. The effect of various parameters such as reaction time, pH, and
B. citriodora
leaf boiling time on the synthesis of Au-NPs was studied. The characterization of the Au-NPs synthesized at 15.0-min incubation time showed colour change because of the surface plasma resonance band around 530.0 nm. TEM photographs showed spherical morphologies with an average size of 8.40 ± 0.084 nm and zeta potential value was − 29.74 mV, indicating stability of the nanoparticles. The biomedical properties of Au-NPs and
B. citriodora
leaf extract showed strong DPPH radical scavenging. The in vitro anticancer activity determined using MTT assay exhibited that Au-NPs showed a significant dose-dependent reduction in the viability of the MCF-7 breast cancer cell line and the HepG2 liver cancer cell line with IC
50
values of 116.65 and 108.21 µg, respectively.</abstract><cop>New York</cop><pub>Springer US</pub><doi>10.1007/s10853-017-1756-4</doi><tpages>13</tpages><orcidid>https://orcid.org/0000-0002-6147-730X</orcidid><orcidid>https://orcid.org/0000-0002-3828-2424</orcidid><orcidid>https://orcid.org/0000-0002-3214-2420</orcidid><orcidid>https://orcid.org/0000-0002-1396-9780</orcidid></addata></record> |
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| subjects | Anticancer properties Biomaterials Biomedical materials Breast cancer Cancer treatment Characterization and Evaluation of Materials Chemistry and Materials Science Classical Mechanics Crystallography and Scattering Methods Gold Health aspects Herbal medicine Liver Liver cancer Materials Science Morphology Nanoparticles Plasma resonance Polymer Sciences Reaction time Reducing agents Scavenging Solid Mechanics Viability Zeta potential |
| title | Synthesis and characterization of gold-conjugated Backhousia citriodora nanoparticles and their anticancer activity against MCF-7 breast and HepG2 liver cancer cell lines |
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