Hollow silica–polyelectrolyte composite nanoparticles for controlled drug delivery
The stimulus-responsive drug delivery system has attracted increasing attention due to its ability to enhance therapeutic efficacy and reduce side effects. Herein, a pH and glutathione (GSH) dually responsive drug carrier, hollow silica–-polyelectrolyte composite nanoparticle, was successfully prepa...
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| Veröffentlicht in: | Journal of materials science 2019-02, Vol.54 (3), p.2552-2565 |
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| container_title | Journal of materials science |
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| creator | Yang, Qingsong Li, Li Zhao, Fang Han, Haoya Wang, Weihua Tian, Yuchuan Wang, Yunwei Ye, Zhishuang Guo, Xuhong |
| description | The stimulus-responsive drug delivery system has attracted increasing attention due to its ability to enhance therapeutic efficacy and reduce side effects. Herein, a pH and glutathione (GSH) dually responsive drug carrier, hollow silica–-polyelectrolyte composite nanoparticle, was successfully prepared by using a template of spherical polyelectrolyte brush (SPB) which consists of a polystyrene (PS) core and a densely grafted linear poly(acrylic acid) (PAA) shell. The existence of PAA chains and introduction of disulfide bonds in silica framework endow the composite nanoparticles with pH and GSH dually responsive properties which were confirmed by dynamic light scattering (DLS) and small-angle X-ray scattering (SAXS). With doxorubicin hydrochloride (DOX) as the model drug, the loading content and encapsulation efficiency could reach up to 43% and 96%, respectively. The drug release behavior was investigated under various environments, showing that the drug release rate increased with the decrease in pH value and the increase in GSH concentration. The prepared hollow SiO
2
–PAA composite nanoparticles possess a great potential as carriers for controlled drug delivery. |
| doi_str_mv | 10.1007/s10853-018-2996-7 |
| format | Article |
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2
–PAA composite nanoparticles possess a great potential as carriers for controlled drug delivery.</description><identifier>ISSN: 0022-2461</identifier><identifier>EISSN: 1573-4803</identifier><identifier>DOI: 10.1007/s10853-018-2996-7</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Acrylic acid ; Characterization and Evaluation of Materials ; Chemistry and Materials Science ; Classical Mechanics ; Crystallography and Scattering Methods ; Doxorubicin ; Drug carriers ; Drug delivery systems ; Glutathione ; Materials for Life Sciences ; Materials Science ; Nanoparticles ; Photon correlation spectroscopy ; Polyelectrolytes ; Polymer Sciences ; Polystyrene resins ; Side effects ; Silicon dioxide ; Small angle X ray scattering ; Solid Mechanics</subject><ispartof>Journal of materials science, 2019-02, Vol.54 (3), p.2552-2565</ispartof><rights>Springer Science+Business Media, LLC, part of Springer Nature 2018</rights><rights>Copyright Springer Science & Business Media 2019</rights><rights>Journal of Materials Science is a copyright of Springer, (2018). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c410t-a419b2bb9afac5ee778cee8ef486c237e97fedad170c494cb60a89a9111c94643</citedby><cites>FETCH-LOGICAL-c410t-a419b2bb9afac5ee778cee8ef486c237e97fedad170c494cb60a89a9111c94643</cites><orcidid>0000-0001-5083-321X ; 0000-0002-1792-8564 ; 0000-0001-9452-4443 ; 0000-0002-1272-4351 ; 0000-0002-0508-2565 ; 0000-0001-5100-734X ; 0000-0002-8575-333X ; 0000-0003-0570-7729 ; 0000-0002-7275-531X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10853-018-2996-7$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10853-018-2996-7$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids></links><search><creatorcontrib>Yang, Qingsong</creatorcontrib><creatorcontrib>Li, Li</creatorcontrib><creatorcontrib>Zhao, Fang</creatorcontrib><creatorcontrib>Han, Haoya</creatorcontrib><creatorcontrib>Wang, Weihua</creatorcontrib><creatorcontrib>Tian, Yuchuan</creatorcontrib><creatorcontrib>Wang, Yunwei</creatorcontrib><creatorcontrib>Ye, Zhishuang</creatorcontrib><creatorcontrib>Guo, Xuhong</creatorcontrib><title>Hollow silica–polyelectrolyte composite nanoparticles for controlled drug delivery</title><title>Journal of materials science</title><addtitle>J Mater Sci</addtitle><description>The stimulus-responsive drug delivery system has attracted increasing attention due to its ability to enhance therapeutic efficacy and reduce side effects. Herein, a pH and glutathione (GSH) dually responsive drug carrier, hollow silica–-polyelectrolyte composite nanoparticle, was successfully prepared by using a template of spherical polyelectrolyte brush (SPB) which consists of a polystyrene (PS) core and a densely grafted linear poly(acrylic acid) (PAA) shell. The existence of PAA chains and introduction of disulfide bonds in silica framework endow the composite nanoparticles with pH and GSH dually responsive properties which were confirmed by dynamic light scattering (DLS) and small-angle X-ray scattering (SAXS). With doxorubicin hydrochloride (DOX) as the model drug, the loading content and encapsulation efficiency could reach up to 43% and 96%, respectively. The drug release behavior was investigated under various environments, showing that the drug release rate increased with the decrease in pH value and the increase in GSH concentration. The prepared hollow SiO
2
–PAA composite nanoparticles possess a great potential as carriers for controlled drug delivery.</description><subject>Acrylic acid</subject><subject>Characterization and Evaluation of Materials</subject><subject>Chemistry and Materials Science</subject><subject>Classical Mechanics</subject><subject>Crystallography and Scattering Methods</subject><subject>Doxorubicin</subject><subject>Drug carriers</subject><subject>Drug delivery systems</subject><subject>Glutathione</subject><subject>Materials for Life Sciences</subject><subject>Materials Science</subject><subject>Nanoparticles</subject><subject>Photon correlation spectroscopy</subject><subject>Polyelectrolytes</subject><subject>Polymer Sciences</subject><subject>Polystyrene resins</subject><subject>Side effects</subject><subject>Silicon dioxide</subject><subject>Small angle X ray scattering</subject><subject>Solid Mechanics</subject><issn>0022-2461</issn><issn>1573-4803</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNp9kMFKxDAQhoMouK4-gLeC52gmTZPmKIu6guBlPYc0nS5dsk1NusrefAff0CexZQVPepof5vtn4CPkEtg1MKZuErCyyCmDknKtJVVHZAaFyqkoWX5MZoxxTrmQcErOUtowxgrFYUZWy-B9eM9S61tnvz4---D36NENcQwDZi5s-5DaMXW2C72NQ-s8pqwJcdx1E-axzuq4W2c1-vYN4_6cnDTWJ7z4mXPycn-3Wizp0_PD4-L2iToBbKBWgK54VWnbWFcgKlU6xBIbUUrHc4VaNVjbGhRzQgtXSWZLbTUAOC2kyOfk6nC3j-F1h2kwm7CL3fjScF5oCVoW8l8Kcp6D1kKNFBwoF0NKERvTx3Zr494AM5Nic1BsRsVmUmymDj900sh2a4y_l_8ufQMz_YEF</recordid><startdate>20190201</startdate><enddate>20190201</enddate><creator>Yang, Qingsong</creator><creator>Li, Li</creator><creator>Zhao, Fang</creator><creator>Han, Haoya</creator><creator>Wang, Weihua</creator><creator>Tian, Yuchuan</creator><creator>Wang, Yunwei</creator><creator>Ye, Zhishuang</creator><creator>Guo, Xuhong</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope><scope>8FE</scope><scope>8FG</scope><scope>ABJCF</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>HCIFZ</scope><scope>KB.</scope><scope>L6V</scope><scope>M7S</scope><scope>PDBOC</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PTHSS</scope><orcidid>https://orcid.org/0000-0001-5083-321X</orcidid><orcidid>https://orcid.org/0000-0002-1792-8564</orcidid><orcidid>https://orcid.org/0000-0001-9452-4443</orcidid><orcidid>https://orcid.org/0000-0002-1272-4351</orcidid><orcidid>https://orcid.org/0000-0002-0508-2565</orcidid><orcidid>https://orcid.org/0000-0001-5100-734X</orcidid><orcidid>https://orcid.org/0000-0002-8575-333X</orcidid><orcidid>https://orcid.org/0000-0003-0570-7729</orcidid><orcidid>https://orcid.org/0000-0002-7275-531X</orcidid></search><sort><creationdate>20190201</creationdate><title>Hollow silica–polyelectrolyte composite nanoparticles for controlled drug delivery</title><author>Yang, Qingsong ; Li, Li ; Zhao, Fang ; Han, Haoya ; Wang, Weihua ; Tian, Yuchuan ; Wang, Yunwei ; Ye, Zhishuang ; Guo, Xuhong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c410t-a419b2bb9afac5ee778cee8ef486c237e97fedad170c494cb60a89a9111c94643</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Acrylic acid</topic><topic>Characterization and Evaluation of Materials</topic><topic>Chemistry and Materials Science</topic><topic>Classical Mechanics</topic><topic>Crystallography and Scattering Methods</topic><topic>Doxorubicin</topic><topic>Drug carriers</topic><topic>Drug delivery systems</topic><topic>Glutathione</topic><topic>Materials for Life Sciences</topic><topic>Materials Science</topic><topic>Nanoparticles</topic><topic>Photon correlation spectroscopy</topic><topic>Polyelectrolytes</topic><topic>Polymer Sciences</topic><topic>Polystyrene resins</topic><topic>Side effects</topic><topic>Silicon dioxide</topic><topic>Small angle X ray scattering</topic><topic>Solid Mechanics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yang, Qingsong</creatorcontrib><creatorcontrib>Li, Li</creatorcontrib><creatorcontrib>Zhao, Fang</creatorcontrib><creatorcontrib>Han, Haoya</creatorcontrib><creatorcontrib>Wang, Weihua</creatorcontrib><creatorcontrib>Tian, Yuchuan</creatorcontrib><creatorcontrib>Wang, Yunwei</creatorcontrib><creatorcontrib>Ye, Zhishuang</creatorcontrib><creatorcontrib>Guo, Xuhong</creatorcontrib><collection>CrossRef</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>SciTech Premium Collection</collection><collection>Materials Science Database</collection><collection>ProQuest Engineering Collection</collection><collection>Engineering Database</collection><collection>Materials Science Collection</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>Engineering Collection</collection><jtitle>Journal of materials science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yang, Qingsong</au><au>Li, Li</au><au>Zhao, Fang</au><au>Han, Haoya</au><au>Wang, Weihua</au><au>Tian, Yuchuan</au><au>Wang, Yunwei</au><au>Ye, Zhishuang</au><au>Guo, Xuhong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hollow silica–polyelectrolyte composite nanoparticles for controlled drug delivery</atitle><jtitle>Journal of materials science</jtitle><stitle>J Mater Sci</stitle><date>2019-02-01</date><risdate>2019</risdate><volume>54</volume><issue>3</issue><spage>2552</spage><epage>2565</epage><pages>2552-2565</pages><issn>0022-2461</issn><eissn>1573-4803</eissn><abstract>The stimulus-responsive drug delivery system has attracted increasing attention due to its ability to enhance therapeutic efficacy and reduce side effects. Herein, a pH and glutathione (GSH) dually responsive drug carrier, hollow silica–-polyelectrolyte composite nanoparticle, was successfully prepared by using a template of spherical polyelectrolyte brush (SPB) which consists of a polystyrene (PS) core and a densely grafted linear poly(acrylic acid) (PAA) shell. The existence of PAA chains and introduction of disulfide bonds in silica framework endow the composite nanoparticles with pH and GSH dually responsive properties which were confirmed by dynamic light scattering (DLS) and small-angle X-ray scattering (SAXS). With doxorubicin hydrochloride (DOX) as the model drug, the loading content and encapsulation efficiency could reach up to 43% and 96%, respectively. The drug release behavior was investigated under various environments, showing that the drug release rate increased with the decrease in pH value and the increase in GSH concentration. The prepared hollow SiO
2
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| subjects | Acrylic acid Characterization and Evaluation of Materials Chemistry and Materials Science Classical Mechanics Crystallography and Scattering Methods Doxorubicin Drug carriers Drug delivery systems Glutathione Materials for Life Sciences Materials Science Nanoparticles Photon correlation spectroscopy Polyelectrolytes Polymer Sciences Polystyrene resins Side effects Silicon dioxide Small angle X ray scattering Solid Mechanics |
| title | Hollow silica–polyelectrolyte composite nanoparticles for controlled drug delivery |
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