Evaluation of the Potential of Cobalamin Derivatives Bearing Ru(II) Polypyridyl Complexes as Photosensitizers for Photodynamic Therapy

Evaluation of the Potential of Cobalamin Derivatives Bearing Ru(II) Polypyridyl Complexes as Photosensitizers for Photodynamic Therapy

The current photosensitizers (PSs) for photodynamic therapy (PDT) lack selectivity for cancer cells. To tackle this drawback, in view of selective cancer delivery, we envisioned conjugating two ruthenium polypyridyl complexes to vitamin B12 (Cobalamin, Cbl) to take advantage of the solubility and ac...

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Veröffentlicht in:Helvetica chimica acta 2019-07, Vol.102 (7), p.n/a
Hauptverfasser: Jakubaszek, Marta, Rossier, Jeremie, Karges, Johannes, Delasoie, Joachim, Goud, Bruno, Gasser, Gilles, Zobi, Fabio
Format: Artikel
Sprache:eng
Schlagworte:
bioinorganic chemistry
Cancer
cobalamines
Coordination compounds
medicinal inorganic chemistry
Metal complexes
Photodynamic therapy
Ruthenium
ruthenium polypyridyl complexes
Selectivity
Vitamin B12
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container_issue 7
container_start_page
container_title Helvetica chimica acta
container_volume 102
creator Jakubaszek, Marta
Rossier, Jeremie
Karges, Johannes
Delasoie, Joachim
Goud, Bruno
Gasser, Gilles
Zobi, Fabio
description The current photosensitizers (PSs) for photodynamic therapy (PDT) lack selectivity for cancer cells. To tackle this drawback, in view of selective cancer delivery, we envisioned conjugating two ruthenium polypyridyl complexes to vitamin B12 (Cobalamin, Cbl) to take advantage of the solubility and active uptake of the latter. Ultimately, our results showed that the transcobalamin pathway is unlikely involved for the delivery of these ruthenium‐based PDT PSs, emphasizing the difficulty in successfully delivering metal complexes to cancer cells.
doi_str_mv 10.1002/hlca.201900104
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subjects bioinorganic chemistry
Cancer
cobalamines
Coordination compounds
medicinal inorganic chemistry
Metal complexes
Photodynamic therapy
Ruthenium
ruthenium polypyridyl complexes
Selectivity
Vitamin B12
title Evaluation of the Potential of Cobalamin Derivatives Bearing Ru(II) Polypyridyl Complexes as Photosensitizers for Photodynamic Therapy
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