Stabilization of TRAIL, an all-²-sheet multimeric protein, using computational redesign

Protein thermal stability is important for therapeutic proteins, both influencing the pharmacokinetic and pharmacodynamic properties and for stability during production and shelf-life of the final product. In this paper we show the redesign of a therapeutically interesting trimeric all-²-sheet prote...

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Veröffentlicht in:	Protein engineering, design and selection design and selection, 2004-09, Vol.17 (9), p.673
Hauptverfasser:	Almer M. van der Sloot, Mullally, Margaret M, Fernandez-Ballester, Gregorio, Serrano, Luis, Quax, Wim J
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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