Antibody–Prodrug Conjugates with KSP Inhibitors and Legumain‐Mediated Metabolite Formation
Invited for the cover of this issue is the group of Hans‐Georg Lerchen and colleagues from Bayer AG R&D Pharmaceuticals. The image, provided by J. Franz and graphic designers from The New Atlantic (Cologne), depicts a cartoon representation of the legumain‐mediated cleavage of the peptide cap wi...
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| Veröffentlicht in: | Chemistry : a European journal 2019-06, Vol.25 (35), p.8175-8175 |
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| container_end_page | 8175 |
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| container_issue | 35 |
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| container_title | Chemistry : a European journal |
| container_volume | 25 |
| creator | Lerchen, Hans‐Georg Stelte‐Ludwig, Beatrix Berndt, Sandra Sommer, Anette Dietz, Lisa Rebstock, Anne‐Sophie Johannes, Sarah Marx, Leo Jörißen, Hannah Mahlert, Christoph Greven, Simone |
| description | Invited for the cover of this issue is the group of Hans‐Georg Lerchen and colleagues from Bayer AG R&D Pharmaceuticals. The image, provided by J. Franz and graphic designers from The New Atlantic (Cologne), depicts a cartoon representation of the legumain‐mediated cleavage of the peptide cap within the lysosome. Read the full text of the article at 10.1002/chem.201900441.
“The use of legumain‐cleavable caps as demonstrated here for antibody‐prodrug conjugates (APDCs) holds promise in applying it to different types of solid tumor indications to improve the therapeutic window.” Read more about the story behind the cover in the Cover Profile and about the research itself on page 8208 ff. (DOI: 10.1002/chem.201900441). |
| doi_str_mv | 10.1002/chem.201901770 |
| format | Article |
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“The use of legumain‐cleavable caps as demonstrated here for antibody‐prodrug conjugates (APDCs) holds promise in applying it to different types of solid tumor indications to improve the therapeutic window.” Read more about the story behind the cover in the Cover Profile and about the research itself on page 8208 ff. (DOI: 10.1002/chem.201900441).</description><identifier>ISSN: 0947-6539</identifier><identifier>EISSN: 1521-3765</identifier><identifier>DOI: 10.1002/chem.201901770</identifier><language>eng</language><publisher>Weinheim: Wiley Subscription Services, Inc</publisher><subject>Antibodies ; Chemistry ; Cologne ; Graphical representations ; Legumain</subject><ispartof>Chemistry : a European journal, 2019-06, Vol.25 (35), p.8175-8175</ispartof><rights>2019 Wiley‐VCH Verlag GmbH & Co. KGaA, Weinheim</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><orcidid>0000-0002-1576-3110 ; 0000-0001-8746-9554</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fchem.201901770$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fchem.201901770$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids></links><search><creatorcontrib>Lerchen, Hans‐Georg</creatorcontrib><creatorcontrib>Stelte‐Ludwig, Beatrix</creatorcontrib><creatorcontrib>Berndt, Sandra</creatorcontrib><creatorcontrib>Sommer, Anette</creatorcontrib><creatorcontrib>Dietz, Lisa</creatorcontrib><creatorcontrib>Rebstock, Anne‐Sophie</creatorcontrib><creatorcontrib>Johannes, Sarah</creatorcontrib><creatorcontrib>Marx, Leo</creatorcontrib><creatorcontrib>Jörißen, Hannah</creatorcontrib><creatorcontrib>Mahlert, Christoph</creatorcontrib><creatorcontrib>Greven, Simone</creatorcontrib><title>Antibody–Prodrug Conjugates with KSP Inhibitors and Legumain‐Mediated Metabolite Formation</title><title>Chemistry : a European journal</title><description>Invited for the cover of this issue is the group of Hans‐Georg Lerchen and colleagues from Bayer AG R&D Pharmaceuticals. The image, provided by J. Franz and graphic designers from The New Atlantic (Cologne), depicts a cartoon representation of the legumain‐mediated cleavage of the peptide cap within the lysosome. Read the full text of the article at 10.1002/chem.201900441.
“The use of legumain‐cleavable caps as demonstrated here for antibody‐prodrug conjugates (APDCs) holds promise in applying it to different types of solid tumor indications to improve the therapeutic window.” Read more about the story behind the cover in the Cover Profile and about the research itself on page 8208 ff. (DOI: 10.1002/chem.201900441).</description><subject>Antibodies</subject><subject>Chemistry</subject><subject>Cologne</subject><subject>Graphical representations</subject><subject>Legumain</subject><issn>0947-6539</issn><issn>1521-3765</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNqFkM1KAzEURoMoWKtb1wHXU5PMT5plKdUWWyyoW0MySdqUzqQmGUp3fQTBN-yTOKWiS1eXC-d89_IBcItRDyNE7sulrnoEYYYwpegMdHBOcJLSIj8HHcQymhR5yi7BVQgrhBAr0rQD3gd1tNKp3WH_NfdO-WYBh65eNQsRdYBbG5fw6WUOJ_XSShudD1DUCk71oqmErQ_7z5lWtmUVnOkopFvbqOGD85WI1tXX4MKIddA3P7ML3h5Gr8NxMn1-nAwH06QkhKJE4TJrvxZSI4VkrnWuTImMLiXCkhkqiSkZbpeszFROW6ifMWWKPiaGKUHTLrg75W68-2h0iHzlGl-3JzkheVrQY3xL9U5U6V0IXhu-8bYSfscx4scO-bFD_tthK7CTsLVrvfuH5sPxaPbnfgMs-XkL</recordid><startdate>20190621</startdate><enddate>20190621</enddate><creator>Lerchen, Hans‐Georg</creator><creator>Stelte‐Ludwig, Beatrix</creator><creator>Berndt, Sandra</creator><creator>Sommer, Anette</creator><creator>Dietz, Lisa</creator><creator>Rebstock, Anne‐Sophie</creator><creator>Johannes, Sarah</creator><creator>Marx, Leo</creator><creator>Jörißen, Hannah</creator><creator>Mahlert, Christoph</creator><creator>Greven, Simone</creator><general>Wiley Subscription Services, Inc</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>8BQ</scope><scope>8FD</scope><scope>JG9</scope><scope>K9.</scope><orcidid>https://orcid.org/0000-0002-1576-3110</orcidid><orcidid>https://orcid.org/0000-0001-8746-9554</orcidid></search><sort><creationdate>20190621</creationdate><title>Antibody–Prodrug Conjugates with KSP Inhibitors and Legumain‐Mediated Metabolite Formation</title><author>Lerchen, Hans‐Georg ; Stelte‐Ludwig, Beatrix ; Berndt, Sandra ; Sommer, Anette ; Dietz, Lisa ; Rebstock, Anne‐Sophie ; Johannes, Sarah ; Marx, Leo ; Jörißen, Hannah ; Mahlert, Christoph ; Greven, Simone</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2270-d1c4017abe0d0b5ee5dfc0fecb01b9f7b2fc91b014c4d570d0849df6812f9da73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Antibodies</topic><topic>Chemistry</topic><topic>Cologne</topic><topic>Graphical representations</topic><topic>Legumain</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lerchen, Hans‐Georg</creatorcontrib><creatorcontrib>Stelte‐Ludwig, Beatrix</creatorcontrib><creatorcontrib>Berndt, Sandra</creatorcontrib><creatorcontrib>Sommer, Anette</creatorcontrib><creatorcontrib>Dietz, Lisa</creatorcontrib><creatorcontrib>Rebstock, Anne‐Sophie</creatorcontrib><creatorcontrib>Johannes, Sarah</creatorcontrib><creatorcontrib>Marx, Leo</creatorcontrib><creatorcontrib>Jörißen, Hannah</creatorcontrib><creatorcontrib>Mahlert, Christoph</creatorcontrib><creatorcontrib>Greven, Simone</creatorcontrib><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Materials Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><jtitle>Chemistry : a European journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lerchen, Hans‐Georg</au><au>Stelte‐Ludwig, Beatrix</au><au>Berndt, Sandra</au><au>Sommer, Anette</au><au>Dietz, Lisa</au><au>Rebstock, Anne‐Sophie</au><au>Johannes, Sarah</au><au>Marx, Leo</au><au>Jörißen, Hannah</au><au>Mahlert, Christoph</au><au>Greven, Simone</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Antibody–Prodrug Conjugates with KSP Inhibitors and Legumain‐Mediated Metabolite Formation</atitle><jtitle>Chemistry : a European journal</jtitle><date>2019-06-21</date><risdate>2019</risdate><volume>25</volume><issue>35</issue><spage>8175</spage><epage>8175</epage><pages>8175-8175</pages><issn>0947-6539</issn><eissn>1521-3765</eissn><abstract>Invited for the cover of this issue is the group of Hans‐Georg Lerchen and colleagues from Bayer AG R&D Pharmaceuticals. The image, provided by J. Franz and graphic designers from The New Atlantic (Cologne), depicts a cartoon representation of the legumain‐mediated cleavage of the peptide cap within the lysosome. Read the full text of the article at 10.1002/chem.201900441.
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| ispartof | Chemistry : a European journal, 2019-06, Vol.25 (35), p.8175-8175 |
| issn | 0947-6539 1521-3765 |
| language | eng |
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| source | Wiley Online Library Journals Frontfile Complete |
| subjects | Antibodies Chemistry Cologne Graphical representations Legumain |
| title | Antibody–Prodrug Conjugates with KSP Inhibitors and Legumain‐Mediated Metabolite Formation |
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