Disruption of stcA blocks sterigmatocystin biosynthesis and improves echinocandin B production in Aspergillus delacroxii

Echinocandin B (ECB) is an important lipohexapeptide used for chemical manufacture of the antifungal agent anidulafungin. Sterigmatocystin (ST) is a polyketide mycotoxin produced by certain species of Aspergillus such as Aspergillus delacroxii SIPIW15, which could produce both ECB and ST. However, t...

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Veröffentlicht in:	World journal of microbiology & biotechnology 2019-07, Vol.35 (7), p.109-12, Article 109
Hauptverfasser:	Min, Taoling, Xiong, Lei, Liang, Yan, Xu, Rui, Fa, Chenchang, Yang, Sheng, Hu, Haifeng
Format:	Artikel
Sprache:	eng
Schlagworte:	Agrobacterium - genetics Anidulafungin Antifungal Agents Applied Microbiology Aspergillus Aspergillus - genetics Aspergillus - metabolism Base Sequence Batch Cell Culture Techniques Batch culture Biochemistry Biomedical and Life Sciences Bioreactors Biosynthesis Biotechnology Carcinogens Disruption DNA, Fungal - isolation & purification Echinocandin B Echinocandins - biosynthesis Echinocandins - genetics Environmental Engineering/Biotechnology Fermentation Fungal Proteins - biosynthesis Fungal Proteins - genetics Fungicides Genes, Fungal - genetics Genetic transformation Life Sciences Metabolic Engineering Metabolic Networks and Pathways - genetics Microbiology Mycotoxins Organic chemistry Original Paper Polyketide synthase Polyketide Synthases - genetics Secondary Metabolism - genetics Sterigmatocystin Sterigmatocystin - biosynthesis Transformation, Genetic
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