Immunomodulation Induced by Avène Spring Water on Th1- and Th2-Dependent Cytokine Production in Healthy Subjects and Atopic Dermatitis Patients
Avène spring water (ASW) is commonly used in France for treating atopic dermatitis and psoriasis. Previous works demonstrated modulation of cell membrane fluidity by ASW. The aims of the present study were (a) to investigate a possible in vitro effect of ASW on Th1- and Th2-dependent cytokine produc...
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| Veröffentlicht in: | Skin pharmacology and applied skin physiology 2001-07, Vol.14 (4), p.234-242 |
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| creator | Portalès, P. Ariès, M.-F. Licu, D. Pinton, J. Hernandez-Pion, C. Gall, Y. Dupuy, P. Charveron, M. Clot, J. |
| description | Avène spring water (ASW) is commonly used in France for treating atopic dermatitis and psoriasis. Previous works demonstrated modulation of cell membrane fluidity by ASW. The aims of the present study were (a) to investigate a possible in vitro effect of ASW on Th1- and Th2-dependent cytokine production using peripheral blood mononuclear cells from healthy individuals and (b) to investigate both the in vitro effect of ASW on AD patients’ cells and the in vivo cellular and clinical modifications induced by a 3-week Avène Medical Spa water cure (AMSWC). The effect of ASW was tested on lymphocyte cultures, which were stimulated in vitro by various mitogens and a superantigen of staphylococcal origin. The lymphocyte proliferation and the production of the cytokines IL-2, IL-4 and IFN-γ were tested. The results showed that ASW-containing medium enhanced the lymphoproliferative response to some mitogens. IL-2 and IFN-γ production were also increased in stimulated culture supernatants. Conversely, ASW-containing medium induced a decrease in IL-4 production by normal peripheral blood lymphocytes. Furthermore, AMSWC was able to amend the clinical features as well as the immunological Th2 profile of atopic dermatitis. |
| doi_str_mv | 10.1159/000056352 |
| format | Article |
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Previous works demonstrated modulation of cell membrane fluidity by ASW. The aims of the present study were (a) to investigate a possible in vitro effect of ASW on Th1- and Th2-dependent cytokine production using peripheral blood mononuclear cells from healthy individuals and (b) to investigate both the in vitro effect of ASW on AD patients’ cells and the in vivo cellular and clinical modifications induced by a 3-week Avène Medical Spa water cure (AMSWC). The effect of ASW was tested on lymphocyte cultures, which were stimulated in vitro by various mitogens and a superantigen of staphylococcal origin. The lymphocyte proliferation and the production of the cytokines IL-2, IL-4 and IFN-γ were tested. The results showed that ASW-containing medium enhanced the lymphoproliferative response to some mitogens. IL-2 and IFN-γ production were also increased in stimulated culture supernatants. Conversely, ASW-containing medium induced a decrease in IL-4 production by normal peripheral blood lymphocytes. Furthermore, AMSWC was able to amend the clinical features as well as the immunological Th2 profile of atopic dermatitis.</description><identifier>ISSN: 1660-5527</identifier><identifier>ISSN: 1422-2868</identifier><identifier>EISSN: 1660-5535</identifier><identifier>EISSN: 1422-2906</identifier><identifier>DOI: 10.1159/000056352</identifier><identifier>PMID: 11464106</identifier><language>eng</language><publisher>Basel, Switzerland: Karger</publisher><subject>Adjuvants, Immunologic - pharmacology ; Adult ; Biological and medical sciences ; Cell Division - drug effects ; Cells, Cultured ; Culture Media ; Cytokines - biosynthesis ; Dermatitis, Atopic - immunology ; Dermatitis, Atopic - metabolism ; Diseases of the skin. Cosmetics ; Female ; Humans ; Male ; Medical sciences ; Middle Aged ; Mineral Waters ; Original Research Article ; Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects) ; Th1 Cells - drug effects ; Th1 Cells - immunology ; Th1 Cells - metabolism ; Th2 Cells - drug effects ; Th2 Cells - immunology ; Th2 Cells - metabolism</subject><ispartof>Skin pharmacology and applied skin physiology, 2001-07, Vol.14 (4), p.234-242</ispartof><rights>2001 S. Karger AG, Basel</rights><rights>2001 INIST-CNRS</rights><rights>Copyright 2001 S. Karger AG, Basel</rights><rights>Copyright (c) 2001 S. 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Previous works demonstrated modulation of cell membrane fluidity by ASW. The aims of the present study were (a) to investigate a possible in vitro effect of ASW on Th1- and Th2-dependent cytokine production using peripheral blood mononuclear cells from healthy individuals and (b) to investigate both the in vitro effect of ASW on AD patients’ cells and the in vivo cellular and clinical modifications induced by a 3-week Avène Medical Spa water cure (AMSWC). The effect of ASW was tested on lymphocyte cultures, which were stimulated in vitro by various mitogens and a superantigen of staphylococcal origin. The lymphocyte proliferation and the production of the cytokines IL-2, IL-4 and IFN-γ were tested. The results showed that ASW-containing medium enhanced the lymphoproliferative response to some mitogens. IL-2 and IFN-γ production were also increased in stimulated culture supernatants. 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Previous works demonstrated modulation of cell membrane fluidity by ASW. The aims of the present study were (a) to investigate a possible in vitro effect of ASW on Th1- and Th2-dependent cytokine production using peripheral blood mononuclear cells from healthy individuals and (b) to investigate both the in vitro effect of ASW on AD patients’ cells and the in vivo cellular and clinical modifications induced by a 3-week Avène Medical Spa water cure (AMSWC). The effect of ASW was tested on lymphocyte cultures, which were stimulated in vitro by various mitogens and a superantigen of staphylococcal origin. The lymphocyte proliferation and the production of the cytokines IL-2, IL-4 and IFN-γ were tested. The results showed that ASW-containing medium enhanced the lymphoproliferative response to some mitogens. IL-2 and IFN-γ production were also increased in stimulated culture supernatants. Conversely, ASW-containing medium induced a decrease in IL-4 production by normal peripheral blood lymphocytes. Furthermore, AMSWC was able to amend the clinical features as well as the immunological Th2 profile of atopic dermatitis.</abstract><cop>Basel, Switzerland</cop><pub>Karger</pub><pmid>11464106</pmid><doi>10.1159/000056352</doi><tpages>9</tpages></addata></record> |
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| ispartof | Skin pharmacology and applied skin physiology, 2001-07, Vol.14 (4), p.234-242 |
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| subjects | Adjuvants, Immunologic - pharmacology Adult Biological and medical sciences Cell Division - drug effects Cells, Cultured Culture Media Cytokines - biosynthesis Dermatitis, Atopic - immunology Dermatitis, Atopic - metabolism Diseases of the skin. Cosmetics Female Humans Male Medical sciences Middle Aged Mineral Waters Original Research Article Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects) Th1 Cells - drug effects Th1 Cells - immunology Th1 Cells - metabolism Th2 Cells - drug effects Th2 Cells - immunology Th2 Cells - metabolism |
| title | Immunomodulation Induced by Avène Spring Water on Th1- and Th2-Dependent Cytokine Production in Healthy Subjects and Atopic Dermatitis Patients |
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