Preview of Potential Therapeutic Applications of Leukotriene B4 Inhibitors in Dermatology
This article reviews the mechanisms and potential therapeutic uses of compounds with inhibitory effects on leukotriene B4 (LTB4) production or its activity, and focuses on compounds that have been shown in animal and/or human studies to have potential efficacy in treating dermatological disorders. T...
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| Veröffentlicht in: | Skin pharmacology and applied skin physiology 2000-09, Vol.13 (5), p.235-245 |
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| container_title | Skin pharmacology and applied skin physiology |
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| creator | Zhu, Y. Isabel Stiller, Matthew J. |
| description | This article reviews the mechanisms and potential therapeutic uses of compounds with inhibitory effects on leukotriene B4 (LTB4) production or its activity, and focuses on compounds that have been shown in animal and/or human studies to have potential efficacy in treating dermatological disorders. These compounds, many of which are not familiar to many dermatologists, include inhibitors of 5-lipoxygenase such as ETH615, 15-hydroxyeicosatetraenoic acid, leflunomide, linetastine, lonapalene, MK886, R-68151 and zileuton, and antagonists of LTB4 such as SC53228, SC50605, SC51146 and VML295. The purpose of this paper is to introduce our colleagues to these potentially useful compounds currently in preclinical or early clinical testing. |
| doi_str_mv | 10.1159/000029929 |
| format | Article |
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Isabel ; Stiller, Matthew J.</creator><creatorcontrib>Zhu, Y. Isabel ; Stiller, Matthew J.</creatorcontrib><description>This article reviews the mechanisms and potential therapeutic uses of compounds with inhibitory effects on leukotriene B4 (LTB4) production or its activity, and focuses on compounds that have been shown in animal and/or human studies to have potential efficacy in treating dermatological disorders. These compounds, many of which are not familiar to many dermatologists, include inhibitors of 5-lipoxygenase such as ETH615, 15-hydroxyeicosatetraenoic acid, leflunomide, linetastine, lonapalene, MK886, R-68151 and zileuton, and antagonists of LTB4 such as SC53228, SC50605, SC51146 and VML295. 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Isabel</creatorcontrib><creatorcontrib>Stiller, Matthew J.</creatorcontrib><title>Preview of Potential Therapeutic Applications of Leukotriene B4 Inhibitors in Dermatology</title><title>Skin pharmacology and applied skin physiology</title><addtitle>Skin Pharmacol Physiol</addtitle><description>This article reviews the mechanisms and potential therapeutic uses of compounds with inhibitory effects on leukotriene B4 (LTB4) production or its activity, and focuses on compounds that have been shown in animal and/or human studies to have potential efficacy in treating dermatological disorders. These compounds, many of which are not familiar to many dermatologists, include inhibitors of 5-lipoxygenase such as ETH615, 15-hydroxyeicosatetraenoic acid, leflunomide, linetastine, lonapalene, MK886, R-68151 and zileuton, and antagonists of LTB4 such as SC53228, SC50605, SC51146 and VML295. The purpose of this paper is to introduce our colleagues to these potentially useful compounds currently in preclinical or early clinical testing.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Humans</subject><subject>Hydroxyeicosatetraenoic Acids - pharmacology</subject><subject>Hydroxyeicosatetraenoic Acids - therapeutic use</subject><subject>Imidazoles - pharmacology</subject><subject>Imidazoles - therapeutic use</subject><subject>Isoxazoles - pharmacology</subject><subject>Isoxazoles - therapeutic use</subject><subject>Leukotriene B4 - antagonists & inhibitors</subject><subject>Leukotriene B4 - biosynthesis</subject><subject>Medical sciences</subject><subject>Original Research Article</subject><subject>Pharmacology. Drug treatments</subject><subject>Piperazines - pharmacology</subject><subject>Piperazines - therapeutic use</subject><subject>Piperidines - pharmacology</subject><subject>Piperidines - therapeutic use</subject><subject>Skin - metabolism</subject><subject>Skin Diseases - drug therapy</subject><subject>Skin, nail, hair, dermoskeleton</subject><issn>1660-5527</issn><issn>1422-2868</issn><issn>1660-5535</issn><issn>1422-2906</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNpt0EtLxDAQB_Agiu-DZ0GKiOBhNa8-cvStsOCCevBU0mSq0W5Tk1Tx25t111XEXCYwP2aSP0JbBB8SkoojHA8VgooFtEqyDA_SlKWL8zvNV9Ca988RZTnJltEKwYLjgrBV9DBy8GbgPbF1MrIB2mBkk9w9gZMd9MGo5LjrGqNkMLb1EzWE_sUGZ6CF5IQn1-2TqUywziemTc7AjWWwjX382EBLtWw8bM7qOrq_OL87vRoMby6vT4-HA8UKHgaUU6G5IEJTpSjHVVVXNUm1kBokcAaQqapSOi-YKCgVOC0yDRWTQhcK45qto_3p3M7Z1x58KMfGK2ga2YLtfZmTPI1B0Ah3_8Bn27s2vq2kNIZEOGYRHUyRctZ7B3XZOTOW7qMkuJyEXc7DjnZnNrCvxqB_yWm6EezNgPRKNrWTrTL-x_F88qHItqfsRbpHcPP-95bdf7u3o6svUHa6Zp-CUprn</recordid><startdate>20000901</startdate><enddate>20000901</enddate><creator>Zhu, Y. 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Isabel ; Stiller, Matthew J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c384t-2429d4919d2cc240bbfbf15d9adeae43ee6cbbcd783982290586deb3a9d8c00f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Humans</topic><topic>Hydroxyeicosatetraenoic Acids - pharmacology</topic><topic>Hydroxyeicosatetraenoic Acids - therapeutic use</topic><topic>Imidazoles - pharmacology</topic><topic>Imidazoles - therapeutic use</topic><topic>Isoxazoles - pharmacology</topic><topic>Isoxazoles - therapeutic use</topic><topic>Leukotriene B4 - antagonists & inhibitors</topic><topic>Leukotriene B4 - biosynthesis</topic><topic>Medical sciences</topic><topic>Original Research Article</topic><topic>Pharmacology. Drug treatments</topic><topic>Piperazines - pharmacology</topic><topic>Piperazines - therapeutic use</topic><topic>Piperidines - pharmacology</topic><topic>Piperidines - therapeutic use</topic><topic>Skin - metabolism</topic><topic>Skin Diseases - drug therapy</topic><topic>Skin, nail, hair, dermoskeleton</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhu, Y. 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| identifier | ISSN: 1660-5527 |
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| source | MEDLINE; Karger_医学期刊; Alma/SFX Local Collection |
| subjects | Animals Biological and medical sciences Humans Hydroxyeicosatetraenoic Acids - pharmacology Hydroxyeicosatetraenoic Acids - therapeutic use Imidazoles - pharmacology Imidazoles - therapeutic use Isoxazoles - pharmacology Isoxazoles - therapeutic use Leukotriene B4 - antagonists & inhibitors Leukotriene B4 - biosynthesis Medical sciences Original Research Article Pharmacology. Drug treatments Piperazines - pharmacology Piperazines - therapeutic use Piperidines - pharmacology Piperidines - therapeutic use Skin - metabolism Skin Diseases - drug therapy Skin, nail, hair, dermoskeleton |
| title | Preview of Potential Therapeutic Applications of Leukotriene B4 Inhibitors in Dermatology |
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