The 5-HT6 Receptor Antagonist SB-271046 Selectively Enhances Excitatory Neurotransmission in the Rat Frontal Cortex and Hippocampus

Preclinical evidence has suggested a possible role for the 5-HT6 receptor in the treatment of cognitive dysfunction. However, currently there is little neurochemical evidence suggesting the mechanism(s) which may be involved. Using the selective 5-HT6 antagonist SB-271046 and in vivo microdialysis,...

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Veröffentlicht in:	Neuropsychopharmacology (New York, N.Y.) N.Y.), 2001-11, Vol.25 (5), p.662-668
Hauptverfasser:	Dawson, Lee A, Nguyen, Huy Q, Li, Ping
Format:	Artikel
Sprache:	eng
Schlagworte:	5-HT6 receptor Anxiety Behavior Biological and medical sciences Brain research Cognition Dorsal hippocampus Frontal cortex Glutamate Medical sciences Memory Microdialysis Neuropharmacology Neurosciences Neurotransmitters. Neurotransmission. Receptors Nucleus accumbens Pharmacology. Drug treatments SB-271046 Serotoninergic system Striatum
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