Brief social defeat stress: Long lasting effects on cocaine taking during a binge and Zif268 mRNA expression in the amygdala and prefrontal cortex
Social stress can engender behavioral and neural sensitization and this process appears to enhance the transition to compulsive drug abuse. Exposures to brief social defeat stress in rats have significant consequences on cocaine-reinforced behavior and on the level of functional activation within re...
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description | Social stress can engender behavioral and neural sensitization and this process appears to enhance the transition to compulsive drug abuse. Exposures to brief social defeat stress in rats have significant consequences on cocaine-reinforced behavior and on the level of functional activation within regions of the mesocorticolimbic dopamine system. The objectives of the current study were to examine the enduring consequences of brief episodes of social defeat stress on cocaine bingeing (during 24 h of continuous access) and on the emergence of neural adaptations as revealed by zif268 immediate early gene expression. Adult, male Long-Evans rats were subjected to four 25 min episodes of social defeat (once every 72 h). After 2 months, cocaine binges or zif268 mRNA gene expression were studied after confirming behavioral cross-sensitization to stimulant challenge. Sensitization to social defeat increased cocaine intake during a 24 h binge, effectively abolishing the typical circadian pattern of intake. Furthermore, 60 days after exposure to the sensitizing regimen of social defeat, levels of functional activation, measured by zif268 mRNA expression, in the central and medial amygdala were increased, while levels of activation in the medial prefrontal cortex were decreased. Persistent stress-induced levels of zif268 in the central and medial amygdala were attenuated by an injection of amphetamine (1.0 mg/kg). Divergent changes in zif268 within the amygdala and cortex 2 months after social defeat stress indicate the vulnerability of distinct cellular populations in networks that modulate the behavioral actions of psychomotor stimulants. |
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Exposures to brief social defeat stress in rats have significant consequences on cocaine-reinforced behavior and on the level of functional activation within regions of the mesocorticolimbic dopamine system. The objectives of the current study were to examine the enduring consequences of brief episodes of social defeat stress on cocaine bingeing (during 24 h of continuous access) and on the emergence of neural adaptations as revealed by zif268 immediate early gene expression. Adult, male Long-Evans rats were subjected to four 25 min episodes of social defeat (once every 72 h). After 2 months, cocaine binges or zif268 mRNA gene expression were studied after confirming behavioral cross-sensitization to stimulant challenge. Sensitization to social defeat increased cocaine intake during a 24 h binge, effectively abolishing the typical circadian pattern of intake. Furthermore, 60 days after exposure to the sensitizing regimen of social defeat, levels of functional activation, measured by zif268 mRNA expression, in the central and medial amygdala were increased, while levels of activation in the medial prefrontal cortex were decreased. Persistent stress-induced levels of zif268 in the central and medial amygdala were attenuated by an injection of amphetamine (1.0 mg/kg). Divergent changes in zif268 within the amygdala and cortex 2 months after social defeat stress indicate the vulnerability of distinct cellular populations in networks that modulate the behavioral actions of psychomotor stimulants.</description><identifier>ISSN: 0893-133X</identifier><identifier>EISSN: 1740-634X</identifier><identifier>DOI: 10.1038/sj.npp.1300587</identifier><identifier>PMID: 15496936</identifier><identifier>CODEN: NEROEW</identifier><language>eng</language><publisher>New York, NY: Nature Publishing</publisher><subject>Amphetamine - pharmacology ; Amphetamines ; Amygdala - drug effects ; Amygdala - metabolism ; Animals ; Behavior ; Biological and medical sciences ; Central Nervous System Stimulants - pharmacology ; Cocaine ; Cocaine - pharmacology ; Cocaine-Related Disorders - psychology ; DNA-Binding Proteins - biosynthesis ; DNA-Binding Proteins - genetics ; Drug addictions ; Early Growth Response Protein 1 ; Gene expression ; Gene Expression - drug effects ; Genes, Immediate-Early - drug effects ; Image Processing, Computer-Assisted ; Immediate-Early Proteins - biosynthesis ; Immediate-Early Proteins - genetics ; In Situ Hybridization ; Male ; Medical sciences ; Physiology ; Prefrontal Cortex - drug effects ; Prefrontal Cortex - metabolism ; Rats ; Rats, Long-Evans ; RNA, Messenger - biosynthesis ; Self Administration ; Social Environment ; Stress, Psychological - psychology ; Toxicology ; Transcription Factors - biosynthesis ; Transcription Factors - genetics</subject><ispartof>Neuropsychopharmacology (New York, N.Y.), 2005-02, Vol.30 (2), p.310-321</ispartof><rights>2005 INIST-CNRS</rights><rights>Copyright Nature Publishing Group Feb 2005</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c456t-9af504363a600c81cf43043e2b711be6669ffd4ceec25aabb6adba0a898ef8ae3</citedby><cites>FETCH-LOGICAL-c456t-9af504363a600c81cf43043e2b711be6669ffd4ceec25aabb6adba0a898ef8ae3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16607706$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15496936$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>COVINGTON, Herbert E</creatorcontrib><creatorcontrib>KIKUSUI, Takefumi</creatorcontrib><creatorcontrib>GOODHUE, Justin</creatorcontrib><creatorcontrib>NIKULINA, Ella M</creatorcontrib><creatorcontrib>HAMMER, Ronald P</creatorcontrib><creatorcontrib>MICZEK, Klaus A</creatorcontrib><title>Brief social defeat stress: Long lasting effects on cocaine taking during a binge and Zif268 mRNA expression in the amygdala and prefrontal cortex</title><title>Neuropsychopharmacology (New York, N.Y.)</title><addtitle>Neuropsychopharmacology</addtitle><description>Social stress can engender behavioral and neural sensitization and this process appears to enhance the transition to compulsive drug abuse. Exposures to brief social defeat stress in rats have significant consequences on cocaine-reinforced behavior and on the level of functional activation within regions of the mesocorticolimbic dopamine system. The objectives of the current study were to examine the enduring consequences of brief episodes of social defeat stress on cocaine bingeing (during 24 h of continuous access) and on the emergence of neural adaptations as revealed by zif268 immediate early gene expression. Adult, male Long-Evans rats were subjected to four 25 min episodes of social defeat (once every 72 h). After 2 months, cocaine binges or zif268 mRNA gene expression were studied after confirming behavioral cross-sensitization to stimulant challenge. Sensitization to social defeat increased cocaine intake during a 24 h binge, effectively abolishing the typical circadian pattern of intake. Furthermore, 60 days after exposure to the sensitizing regimen of social defeat, levels of functional activation, measured by zif268 mRNA expression, in the central and medial amygdala were increased, while levels of activation in the medial prefrontal cortex were decreased. Persistent stress-induced levels of zif268 in the central and medial amygdala were attenuated by an injection of amphetamine (1.0 mg/kg). Divergent changes in zif268 within the amygdala and cortex 2 months after social defeat stress indicate the vulnerability of distinct cellular populations in networks that modulate the behavioral actions of psychomotor stimulants.</description><subject>Amphetamine - pharmacology</subject><subject>Amphetamines</subject><subject>Amygdala - drug effects</subject><subject>Amygdala - metabolism</subject><subject>Animals</subject><subject>Behavior</subject><subject>Biological and medical sciences</subject><subject>Central Nervous System Stimulants - pharmacology</subject><subject>Cocaine</subject><subject>Cocaine - pharmacology</subject><subject>Cocaine-Related Disorders - psychology</subject><subject>DNA-Binding Proteins - biosynthesis</subject><subject>DNA-Binding Proteins - genetics</subject><subject>Drug addictions</subject><subject>Early Growth Response Protein 1</subject><subject>Gene expression</subject><subject>Gene Expression - drug effects</subject><subject>Genes, Immediate-Early - 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pharmacology</topic><topic>Amphetamines</topic><topic>Amygdala - drug effects</topic><topic>Amygdala - metabolism</topic><topic>Animals</topic><topic>Behavior</topic><topic>Biological and medical sciences</topic><topic>Central Nervous System Stimulants - pharmacology</topic><topic>Cocaine</topic><topic>Cocaine - pharmacology</topic><topic>Cocaine-Related Disorders - psychology</topic><topic>DNA-Binding Proteins - biosynthesis</topic><topic>DNA-Binding Proteins - genetics</topic><topic>Drug addictions</topic><topic>Early Growth Response Protein 1</topic><topic>Gene expression</topic><topic>Gene Expression - drug effects</topic><topic>Genes, Immediate-Early - drug effects</topic><topic>Image Processing, Computer-Assisted</topic><topic>Immediate-Early Proteins - biosynthesis</topic><topic>Immediate-Early Proteins - genetics</topic><topic>In Situ Hybridization</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Physiology</topic><topic>Prefrontal Cortex - drug effects</topic><topic>Prefrontal Cortex - 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Exposures to brief social defeat stress in rats have significant consequences on cocaine-reinforced behavior and on the level of functional activation within regions of the mesocorticolimbic dopamine system. The objectives of the current study were to examine the enduring consequences of brief episodes of social defeat stress on cocaine bingeing (during 24 h of continuous access) and on the emergence of neural adaptations as revealed by zif268 immediate early gene expression. Adult, male Long-Evans rats were subjected to four 25 min episodes of social defeat (once every 72 h). After 2 months, cocaine binges or zif268 mRNA gene expression were studied after confirming behavioral cross-sensitization to stimulant challenge. Sensitization to social defeat increased cocaine intake during a 24 h binge, effectively abolishing the typical circadian pattern of intake. Furthermore, 60 days after exposure to the sensitizing regimen of social defeat, levels of functional activation, measured by zif268 mRNA expression, in the central and medial amygdala were increased, while levels of activation in the medial prefrontal cortex were decreased. Persistent stress-induced levels of zif268 in the central and medial amygdala were attenuated by an injection of amphetamine (1.0 mg/kg). Divergent changes in zif268 within the amygdala and cortex 2 months after social defeat stress indicate the vulnerability of distinct cellular populations in networks that modulate the behavioral actions of psychomotor stimulants.</abstract><cop>New York, NY</cop><pub>Nature Publishing</pub><pmid>15496936</pmid><doi>10.1038/sj.npp.1300587</doi><tpages>12</tpages><oa>free_for_read</oa></addata></record> |
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subjects | Amphetamine - pharmacology Amphetamines Amygdala - drug effects Amygdala - metabolism Animals Behavior Biological and medical sciences Central Nervous System Stimulants - pharmacology Cocaine Cocaine - pharmacology Cocaine-Related Disorders - psychology DNA-Binding Proteins - biosynthesis DNA-Binding Proteins - genetics Drug addictions Early Growth Response Protein 1 Gene expression Gene Expression - drug effects Genes, Immediate-Early - drug effects Image Processing, Computer-Assisted Immediate-Early Proteins - biosynthesis Immediate-Early Proteins - genetics In Situ Hybridization Male Medical sciences Physiology Prefrontal Cortex - drug effects Prefrontal Cortex - metabolism Rats Rats, Long-Evans RNA, Messenger - biosynthesis Self Administration Social Environment Stress, Psychological - psychology Toxicology Transcription Factors - biosynthesis Transcription Factors - genetics |
title | Brief social defeat stress: Long lasting effects on cocaine taking during a binge and Zif268 mRNA expression in the amygdala and prefrontal cortex |
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