Olanzapine Reduces Craving for Alcohol: A DRD4 VNTR Polymorphism by Pharmacotherapy Interaction

Separate investigations have suggested that olanzapine, a D4 antagonist, decreases craving after a priming dose of alcohol and that the DRD4 variable number of tandem repeats (VNTR) polymorphism influences the expression of craving after a priming dose of alcohol. The present study tested the hypoth...

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Veröffentlicht in:	Neuropsychopharmacology (New York, N.Y.) N.Y.), 2003-10, Vol.28 (10), p.1882-1888
Hauptverfasser:	Hutchison, Kent E, Wooden, Angela, Swift, Robert M, Smolen, Andrew, McGeary, John, Adler, Lawrence, Paris, Lyndee
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Affect - drug effects Alcohol Drinking - drug therapy Alcohol Drinking - genetics Behavior, Addictive - drug therapy Behavior, Addictive - genetics Behavioral Sciences Benzodiazepines Biological and medical sciences Biological Psychology Case-Control Studies Central Nervous System Depressants Chi-Square Distribution Cues Cyproheptadine - therapeutic use Dose-Response Relationship, Drug Double-Blind Method Drug Interactions Ethanol - adverse effects Ethanol - pharmacology Female Humans Individuality Male Medical sciences Medicine Medicine & Public Health Minisatellite Repeats - genetics Neuropharmacology Neurosciences original-article Pharmacology. Drug treatments Pharmacotherapy Pirenzepine - analogs & derivatives Pirenzepine - therapeutic use Polymorphism, Genetic Psychiatry Psycholeptics: tranquillizer, neuroleptic Psychology. Psychoanalysis. Psychiatry Psychopharmacology Receptors, Dopamine D2 - genetics Receptors, Dopamine D4 Serotonin Antagonists - therapeutic use Serotonin Uptake Inhibitors - therapeutic use
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