Association of DNA polymorphisms in the synaptic vesicular amine transporter gene (SLCI8A2) with alcohol and nicotine dependence
The brain synaptic vesicular amine transporter SLCA18A2 is a key component for the uptake of monoamines like dopamine or serotonin into vesicles. We have analyzed seven DNA polymorphisms located in the genomic region of SLC18A2 for association with alcohol- and nicotine dependence, using a family-ba...
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| Veröffentlicht in: | Neuropsychopharmacology (New York, N.Y.) N.Y.), 2005-12, Vol.30 (12), p.2263-2268 |
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| creator | SCHWAB, Sibylle G FRANKE, Petra E HOEFGEN, Barbara GUTTENTHALER, Vera LICHTERMANN, Dirk TRIXLER, Matyas KNAPP, Michael MAIER, Wolfgang WILDENAUER, Dieter B |
| description | The brain synaptic vesicular amine transporter SLCA18A2 is a key component for the uptake of monoamines like dopamine or serotonin into vesicles. We have analyzed seven DNA polymorphisms located in the genomic region of SLC18A2 for association with alcohol- and nicotine dependence, using a family-based design. Our sample comprised 131 families with alcohol-dependent offspring and 96 families with at least one nicotine-dependent offspring. For the alcohol-dependent sample, we found statistical significant association for two single markers (rs363387, P=0.03; rs363333, P=0.0066) as well as for several haplotypes (minimal P=0.0038). When the sample with alcohol dependence was stratified according to gender, we observed increased association for the male subgroup (rs363387, P=0.0011). None of the markers showed association in the sample of families with nicotine dependence. However, analysis of a combined sample of alcohol and nicotine-dependent families resulted in single markers as well as several haplotypes showing statistical significant association with substance dependence (minimal P=0.0044). We conclude that DNA polymorphisms located in SLC18A2 might contribute to the development of substance dependence. |
| doi_str_mv | 10.1038/sj.npp.1300809 |
| format | Article |
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We have analyzed seven DNA polymorphisms located in the genomic region of SLC18A2 for association with alcohol- and nicotine dependence, using a family-based design. Our sample comprised 131 families with alcohol-dependent offspring and 96 families with at least one nicotine-dependent offspring. For the alcohol-dependent sample, we found statistical significant association for two single markers (rs363387, P=0.03; rs363333, P=0.0066) as well as for several haplotypes (minimal P=0.0038). When the sample with alcohol dependence was stratified according to gender, we observed increased association for the male subgroup (rs363387, P=0.0011). None of the markers showed association in the sample of families with nicotine dependence. However, analysis of a combined sample of alcohol and nicotine-dependent families resulted in single markers as well as several haplotypes showing statistical significant association with substance dependence (minimal P=0.0044). We conclude that DNA polymorphisms located in SLC18A2 might contribute to the development of substance dependence.</description><identifier>ISSN: 0893-133X</identifier><identifier>EISSN: 1740-634X</identifier><identifier>DOI: 10.1038/sj.npp.1300809</identifier><identifier>PMID: 15988470</identifier><identifier>CODEN: NEROEW</identifier><language>eng</language><publisher>New York, NY: Nature Publishing</publisher><subject>Adult ; Aged ; Alcoholism ; Alcoholism - epidemiology ; Alcoholism - genetics ; Alcoholism - psychology ; Alcoholism and acute alcohol poisoning ; Biological and medical sciences ; Brain research ; Dependent sample ; DNA - genetics ; Dopamine ; Female ; Genetic Markers ; Genotype ; Haplotypes ; Humans ; Linkage Disequilibrium - genetics ; Male ; Medical research ; Medical sciences ; Middle Aged ; Nicotine ; Polymorphism, Genetic - genetics ; Psychiatric Status Rating Scales ; Psychiatry ; Serotonin ; Sex Characteristics ; Smoking ; Tobacco Use Disorder - epidemiology ; Tobacco Use Disorder - genetics ; Tobacco Use Disorder - psychology ; Toxicology ; Twins ; Vesicular Monoamine Transport Proteins - genetics</subject><ispartof>Neuropsychopharmacology (New York, N.Y.), 2005-12, Vol.30 (12), p.2263-2268</ispartof><rights>2006 INIST-CNRS</rights><rights>Copyright Nature Publishing Group Dec 2005</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c390t-325f8b9ca0b1b62bb56f0d128e5b49d666dea48f98b70173594e421e7baf60a13</citedby><cites>FETCH-LOGICAL-c390t-325f8b9ca0b1b62bb56f0d128e5b49d666dea48f98b70173594e421e7baf60a13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17283961$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15988470$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>SCHWAB, Sibylle G</creatorcontrib><creatorcontrib>FRANKE, Petra E</creatorcontrib><creatorcontrib>HOEFGEN, Barbara</creatorcontrib><creatorcontrib>GUTTENTHALER, Vera</creatorcontrib><creatorcontrib>LICHTERMANN, Dirk</creatorcontrib><creatorcontrib>TRIXLER, Matyas</creatorcontrib><creatorcontrib>KNAPP, Michael</creatorcontrib><creatorcontrib>MAIER, Wolfgang</creatorcontrib><creatorcontrib>WILDENAUER, Dieter B</creatorcontrib><title>Association of DNA polymorphisms in the synaptic vesicular amine transporter gene (SLCI8A2) with alcohol and nicotine dependence</title><title>Neuropsychopharmacology (New York, N.Y.)</title><addtitle>Neuropsychopharmacology</addtitle><description>The brain synaptic vesicular amine transporter SLCA18A2 is a key component for the uptake of monoamines like dopamine or serotonin into vesicles. We have analyzed seven DNA polymorphisms located in the genomic region of SLC18A2 for association with alcohol- and nicotine dependence, using a family-based design. Our sample comprised 131 families with alcohol-dependent offspring and 96 families with at least one nicotine-dependent offspring. For the alcohol-dependent sample, we found statistical significant association for two single markers (rs363387, P=0.03; rs363333, P=0.0066) as well as for several haplotypes (minimal P=0.0038). When the sample with alcohol dependence was stratified according to gender, we observed increased association for the male subgroup (rs363387, P=0.0011). None of the markers showed association in the sample of families with nicotine dependence. However, analysis of a combined sample of alcohol and nicotine-dependent families resulted in single markers as well as several haplotypes showing statistical significant association with substance dependence (minimal P=0.0044). 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We have analyzed seven DNA polymorphisms located in the genomic region of SLC18A2 for association with alcohol- and nicotine dependence, using a family-based design. Our sample comprised 131 families with alcohol-dependent offspring and 96 families with at least one nicotine-dependent offspring. For the alcohol-dependent sample, we found statistical significant association for two single markers (rs363387, P=0.03; rs363333, P=0.0066) as well as for several haplotypes (minimal P=0.0038). When the sample with alcohol dependence was stratified according to gender, we observed increased association for the male subgroup (rs363387, P=0.0011). None of the markers showed association in the sample of families with nicotine dependence. However, analysis of a combined sample of alcohol and nicotine-dependent families resulted in single markers as well as several haplotypes showing statistical significant association with substance dependence (minimal P=0.0044). We conclude that DNA polymorphisms located in SLC18A2 might contribute to the development of substance dependence.</abstract><cop>New York, NY</cop><pub>Nature Publishing</pub><pmid>15988470</pmid><doi>10.1038/sj.npp.1300809</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Aged Alcoholism Alcoholism - epidemiology Alcoholism - genetics Alcoholism - psychology Alcoholism and acute alcohol poisoning Biological and medical sciences Brain research Dependent sample DNA - genetics Dopamine Female Genetic Markers Genotype Haplotypes Humans Linkage Disequilibrium - genetics Male Medical research Medical sciences Middle Aged Nicotine Polymorphism, Genetic - genetics Psychiatric Status Rating Scales Psychiatry Serotonin Sex Characteristics Smoking Tobacco Use Disorder - epidemiology Tobacco Use Disorder - genetics Tobacco Use Disorder - psychology Toxicology Twins Vesicular Monoamine Transport Proteins - genetics |
| title | Association of DNA polymorphisms in the synaptic vesicular amine transporter gene (SLCI8A2) with alcohol and nicotine dependence |
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