Limbic Activation to Cigarette Smoking Cues Independent of Nicotine Withdrawal: A Perfusion fMRI Study
Exposure to cigarette smoking cues can trigger physiological arousal and desire to smoke. The brain substrates of smoking cue-induced craving (CIC) are beginning to be elucidated; however, it has been difficult to study this state independent of the potential contributions of pharmacological withdra...
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| Veröffentlicht in: | Neuropsychopharmacology (New York, N.Y.) N.Y.), 2007-11, Vol.32 (11), p.2301-2309 |
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| creator | Franklin, Teresa R wang, Ze Wang, Jiongjiong Sciortino, Nathan Harper, Derek Li, Yin Ehrman, Ron Kampman, Kyle O'Brien, Charles P Detre, John A Childress, Anna Rose |
| description | Exposure to cigarette smoking cues can trigger physiological arousal and desire to smoke. The brain substrates of smoking cue-induced craving (CIC) are beginning to be elucidated; however, it has been difficult to study this state independent of the potential contributions of pharmacological withdrawal from nicotine. Pharmacological withdrawal itself may have substantial effects on brain activation to cues, either by obscuring or enhancing it, and as CIC is not reduced by nicotine replacement strategies, its neuro-anatomical substrates may differ. Thus, characterizing CIC is critical for developing effective interventions. This study used arterial spin-labeled (ASL) perfusion fMRI, and newly developed and highly appetitive, explicit smoking stimuli, to examine neural activity to cigarette CIC in an original experimental design that strongly minimizes contributions from pharmacological withdrawal. Twenty-one smokers (12 females) completed smoking and nonsmoking cue fMRI sessions. Craving self-reports were collected before and after each session. SPM2 software was employed to analyze data. Blood flow (perfusion) in
a priori
-selected regions was greater during exposure to smoking stimuli compared to nonsmoking stimuli (
p |
| doi_str_mv | 10.1038/sj.npp.1301371 |
| format | Article |
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a priori
-selected regions was greater during exposure to smoking stimuli compared to nonsmoking stimuli (
p
<0.01; corrected) in ventral striatum, amygdala, orbitofrontal cortex, hippocampus, medial thalamus, and left insula. Perfusion positively correlated with intensity of cigarette CIC in both the dorsolateral prefrontal cortex (
r
2
=0.54) and posterior cingulate (
r
2
=0.53). This pattern of activation that includes the ventral striatum, a critical reward substrate, and the interconnected amygdala, cingulate and OFC, is consistent with decades of animal research on the neural correlates of conditioned drug reward.</description><identifier>ISSN: 0893-133X</identifier><identifier>EISSN: 1740-634X</identifier><identifier>DOI: 10.1038/sj.npp.1301371</identifier><identifier>PMID: 17375140</identifier><identifier>CODEN: NEROEW</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>Addictive behaviors ; Adolescent ; Adult ; Adult and adolescent clinical studies ; Behavioral Sciences ; Biological and medical sciences ; Biological Psychology ; Brain Mapping ; Brain research ; Cigarettes ; Conditioning, Operant - drug effects ; Conditioning, Operant - physiology ; Cues ; Drug withdrawal ; Female ; Humans ; Image Processing, Computer-Assisted - methods ; Limbic System - blood supply ; Magnetic Resonance Imaging ; Male ; Medical imaging ; Medical sciences ; Medicine ; Medicine & Public Health ; Middle Aged ; Neuroimaging ; Neurosciences ; Nicotine ; Nicotine - adverse effects ; original-article ; Oxygen - blood ; Pharmacotherapy ; Psychiatry ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry ; Smoking ; Smoking - psychology ; Tobacco smoking ; Tobacco Use Disorder - physiopathology ; Tobacco Use Disorder - psychology ; Tobacco, tobacco smoking ; Toxicology</subject><ispartof>Neuropsychopharmacology (New York, N.Y.), 2007-11, Vol.32 (11), p.2301-2309</ispartof><rights>American College of Neuropsychopharmacology 2007</rights><rights>2007 INIST-CNRS</rights><rights>Copyright Nature Publishing Group Nov 2007</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c452t-95769f7962e75dbdb8adff0a22f6367426e0568da003eb3fbac9bb710c5591aa3</citedby><cites>FETCH-LOGICAL-c452t-95769f7962e75dbdb8adff0a22f6367426e0568da003eb3fbac9bb710c5591aa3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/sj.npp.1301371$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/sj.npp.1301371$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19171977$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17375140$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Franklin, Teresa R</creatorcontrib><creatorcontrib>wang, Ze</creatorcontrib><creatorcontrib>Wang, Jiongjiong</creatorcontrib><creatorcontrib>Sciortino, Nathan</creatorcontrib><creatorcontrib>Harper, Derek</creatorcontrib><creatorcontrib>Li, Yin</creatorcontrib><creatorcontrib>Ehrman, Ron</creatorcontrib><creatorcontrib>Kampman, Kyle</creatorcontrib><creatorcontrib>O'Brien, Charles P</creatorcontrib><creatorcontrib>Detre, John A</creatorcontrib><creatorcontrib>Childress, Anna Rose</creatorcontrib><title>Limbic Activation to Cigarette Smoking Cues Independent of Nicotine Withdrawal: A Perfusion fMRI Study</title><title>Neuropsychopharmacology (New York, N.Y.)</title><addtitle>Neuropsychopharmacol</addtitle><addtitle>Neuropsychopharmacology</addtitle><description>Exposure to cigarette smoking cues can trigger physiological arousal and desire to smoke. The brain substrates of smoking cue-induced craving (CIC) are beginning to be elucidated; however, it has been difficult to study this state independent of the potential contributions of pharmacological withdrawal from nicotine. Pharmacological withdrawal itself may have substantial effects on brain activation to cues, either by obscuring or enhancing it, and as CIC is not reduced by nicotine replacement strategies, its neuro-anatomical substrates may differ. Thus, characterizing CIC is critical for developing effective interventions. This study used arterial spin-labeled (ASL) perfusion fMRI, and newly developed and highly appetitive, explicit smoking stimuli, to examine neural activity to cigarette CIC in an original experimental design that strongly minimizes contributions from pharmacological withdrawal. Twenty-one smokers (12 females) completed smoking and nonsmoking cue fMRI sessions. Craving self-reports were collected before and after each session. SPM2 software was employed to analyze data. Blood flow (perfusion) in
a priori
-selected regions was greater during exposure to smoking stimuli compared to nonsmoking stimuli (
p
<0.01; corrected) in ventral striatum, amygdala, orbitofrontal cortex, hippocampus, medial thalamus, and left insula. Perfusion positively correlated with intensity of cigarette CIC in both the dorsolateral prefrontal cortex (
r
2
=0.54) and posterior cingulate (
r
2
=0.53). This pattern of activation that includes the ventral striatum, a critical reward substrate, and the interconnected amygdala, cingulate and OFC, is consistent with decades of animal research on the neural correlates of conditioned drug reward.</description><subject>Addictive behaviors</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Adult and adolescent clinical studies</subject><subject>Behavioral Sciences</subject><subject>Biological and medical sciences</subject><subject>Biological Psychology</subject><subject>Brain Mapping</subject><subject>Brain research</subject><subject>Cigarettes</subject><subject>Conditioning, Operant - drug effects</subject><subject>Conditioning, Operant - physiology</subject><subject>Cues</subject><subject>Drug withdrawal</subject><subject>Female</subject><subject>Humans</subject><subject>Image Processing, Computer-Assisted - methods</subject><subject>Limbic System - blood supply</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Medical imaging</subject><subject>Medical sciences</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Neuroimaging</subject><subject>Neurosciences</subject><subject>Nicotine</subject><subject>Nicotine - adverse effects</subject><subject>original-article</subject><subject>Oxygen - blood</subject><subject>Pharmacotherapy</subject><subject>Psychiatry</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. Psychiatry</subject><subject>Smoking</subject><subject>Smoking - psychology</subject><subject>Tobacco smoking</subject><subject>Tobacco Use Disorder - physiopathology</subject><subject>Tobacco Use Disorder - psychology</subject><subject>Tobacco, tobacco smoking</subject><subject>Toxicology</subject><issn>0893-133X</issn><issn>1740-634X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp1kElPwzAQhS0EglK4cgNZSBxTvCRxwq2KWCqVRSyCW-Q4dnFpnWA7oP57XDVST1xmDvO9N08PgBOMRhjR7NLNR6ZtR5giTBneAQPMYhSlNP7YBQOU5TTClH4cgEPn5gjhhKXZPjjAjLIEx2gA1FQvKy3gWHj9w71uDPQNLPSMW-m9hC_L5kubGSw66eDE1LKVYRgPGwUftGi8NhK-a_9ZW_7LF1dwDJ-kVZ1bO6n75wl88V29OgJ7ii-cPO73ELzdXL8Wd9H08XZSjKeRiBPiozzkyxXLUyJZUld1lfFaKcQJUSlNWUxSiZI0qzlCVFZUVVzkVcUwEkmSY87pEJxvfFvbfIfIvpw3nTXhZUlIQmgcYxKg0QYStnHOSlW2Vi-5XZUYletWSzcvQ6tl32oQnPWuXbWU9RbvawzARQ9wJ_hCWW6EdlsuxwznjAXucsO5cDIzabfx_n19ulEY7jsrt5b9_Q9Et5pb</recordid><startdate>20071101</startdate><enddate>20071101</enddate><creator>Franklin, Teresa R</creator><creator>wang, Ze</creator><creator>Wang, Jiongjiong</creator><creator>Sciortino, Nathan</creator><creator>Harper, Derek</creator><creator>Li, Yin</creator><creator>Ehrman, Ron</creator><creator>Kampman, Kyle</creator><creator>O'Brien, Charles P</creator><creator>Detre, John A</creator><creator>Childress, Anna Rose</creator><general>Springer International Publishing</general><general>Nature Publishing</general><general>Nature Publishing Group</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope></search><sort><creationdate>20071101</creationdate><title>Limbic Activation to Cigarette Smoking Cues Independent of Nicotine Withdrawal: A Perfusion fMRI Study</title><author>Franklin, Teresa R ; wang, Ze ; Wang, Jiongjiong ; Sciortino, Nathan ; Harper, Derek ; Li, Yin ; Ehrman, Ron ; Kampman, Kyle ; O'Brien, Charles P ; Detre, John A ; Childress, Anna Rose</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c452t-95769f7962e75dbdb8adff0a22f6367426e0568da003eb3fbac9bb710c5591aa3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Addictive behaviors</topic><topic>Adolescent</topic><topic>Adult</topic><topic>Adult and adolescent clinical studies</topic><topic>Behavioral Sciences</topic><topic>Biological and medical sciences</topic><topic>Biological Psychology</topic><topic>Brain Mapping</topic><topic>Brain research</topic><topic>Cigarettes</topic><topic>Conditioning, Operant - drug effects</topic><topic>Conditioning, Operant - physiology</topic><topic>Cues</topic><topic>Drug withdrawal</topic><topic>Female</topic><topic>Humans</topic><topic>Image Processing, Computer-Assisted - methods</topic><topic>Limbic System - blood supply</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Medical imaging</topic><topic>Medical sciences</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Neuroimaging</topic><topic>Neurosciences</topic><topic>Nicotine</topic><topic>Nicotine - adverse effects</topic><topic>original-article</topic><topic>Oxygen - blood</topic><topic>Pharmacotherapy</topic><topic>Psychiatry</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopathology. Psychiatry</topic><topic>Smoking</topic><topic>Smoking - psychology</topic><topic>Tobacco smoking</topic><topic>Tobacco Use Disorder - physiopathology</topic><topic>Tobacco Use Disorder - psychology</topic><topic>Tobacco, tobacco smoking</topic><topic>Toxicology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Franklin, Teresa R</creatorcontrib><creatorcontrib>wang, Ze</creatorcontrib><creatorcontrib>Wang, Jiongjiong</creatorcontrib><creatorcontrib>Sciortino, Nathan</creatorcontrib><creatorcontrib>Harper, Derek</creatorcontrib><creatorcontrib>Li, Yin</creatorcontrib><creatorcontrib>Ehrman, Ron</creatorcontrib><creatorcontrib>Kampman, Kyle</creatorcontrib><creatorcontrib>O'Brien, Charles P</creatorcontrib><creatorcontrib>Detre, John A</creatorcontrib><creatorcontrib>Childress, Anna Rose</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection (ProQuest)</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Psychology Database</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><jtitle>Neuropsychopharmacology (New York, N.Y.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Franklin, Teresa R</au><au>wang, Ze</au><au>Wang, Jiongjiong</au><au>Sciortino, Nathan</au><au>Harper, Derek</au><au>Li, Yin</au><au>Ehrman, Ron</au><au>Kampman, Kyle</au><au>O'Brien, Charles P</au><au>Detre, John A</au><au>Childress, Anna Rose</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Limbic Activation to Cigarette Smoking Cues Independent of Nicotine Withdrawal: A Perfusion fMRI Study</atitle><jtitle>Neuropsychopharmacology (New York, N.Y.)</jtitle><stitle>Neuropsychopharmacol</stitle><addtitle>Neuropsychopharmacology</addtitle><date>2007-11-01</date><risdate>2007</risdate><volume>32</volume><issue>11</issue><spage>2301</spage><epage>2309</epage><pages>2301-2309</pages><issn>0893-133X</issn><eissn>1740-634X</eissn><coden>NEROEW</coden><abstract>Exposure to cigarette smoking cues can trigger physiological arousal and desire to smoke. The brain substrates of smoking cue-induced craving (CIC) are beginning to be elucidated; however, it has been difficult to study this state independent of the potential contributions of pharmacological withdrawal from nicotine. Pharmacological withdrawal itself may have substantial effects on brain activation to cues, either by obscuring or enhancing it, and as CIC is not reduced by nicotine replacement strategies, its neuro-anatomical substrates may differ. Thus, characterizing CIC is critical for developing effective interventions. This study used arterial spin-labeled (ASL) perfusion fMRI, and newly developed and highly appetitive, explicit smoking stimuli, to examine neural activity to cigarette CIC in an original experimental design that strongly minimizes contributions from pharmacological withdrawal. Twenty-one smokers (12 females) completed smoking and nonsmoking cue fMRI sessions. Craving self-reports were collected before and after each session. SPM2 software was employed to analyze data. Blood flow (perfusion) in
a priori
-selected regions was greater during exposure to smoking stimuli compared to nonsmoking stimuli (
p
<0.01; corrected) in ventral striatum, amygdala, orbitofrontal cortex, hippocampus, medial thalamus, and left insula. Perfusion positively correlated with intensity of cigarette CIC in both the dorsolateral prefrontal cortex (
r
2
=0.54) and posterior cingulate (
r
2
=0.53). This pattern of activation that includes the ventral striatum, a critical reward substrate, and the interconnected amygdala, cingulate and OFC, is consistent with decades of animal research on the neural correlates of conditioned drug reward.</abstract><cop>Cham</cop><pub>Springer International Publishing</pub><pmid>17375140</pmid><doi>10.1038/sj.npp.1301371</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Neuropsychopharmacology (New York, N.Y.), 2007-11, Vol.32 (11), p.2301-2309 |
| issn | 0893-133X 1740-634X |
| language | eng |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; SpringerLink Journals - AutoHoldings |
| subjects | Addictive behaviors Adolescent Adult Adult and adolescent clinical studies Behavioral Sciences Biological and medical sciences Biological Psychology Brain Mapping Brain research Cigarettes Conditioning, Operant - drug effects Conditioning, Operant - physiology Cues Drug withdrawal Female Humans Image Processing, Computer-Assisted - methods Limbic System - blood supply Magnetic Resonance Imaging Male Medical imaging Medical sciences Medicine Medicine & Public Health Middle Aged Neuroimaging Neurosciences Nicotine Nicotine - adverse effects original-article Oxygen - blood Pharmacotherapy Psychiatry Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Smoking Smoking - psychology Tobacco smoking Tobacco Use Disorder - physiopathology Tobacco Use Disorder - psychology Tobacco, tobacco smoking Toxicology |
| title | Limbic Activation to Cigarette Smoking Cues Independent of Nicotine Withdrawal: A Perfusion fMRI Study |
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