Toward a Neuro-Cognitive Animal Model of the Cognitive Symptoms of Schizophrenia: Disruption of Cortical Cholinergic Neurotransmission Following Repeated Amphetamine Exposure in Attentional Task-Performing, but Not Non-Performing, Rats

Impairments in attentional functions and capacities represent core aspects of the cognitive symptoms of schizophrenia. Attentional performance has been demonstrated to depend on the integrity and activity of cortical cholinergic inputs. The neurobiological, behavioral, and cognitive effects of repea...

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Veröffentlicht in:	Neuropsychopharmacology (New York, N.Y.) N.Y.), 2007-10, Vol.32 (10), p.2074-2086
Hauptverfasser:	KOZAK, Rouba, MARTINEZ, Vicente, YOUNG, Damon, BROWN, Holden, BRUNO, John P, SARTER, Martin
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholine - metabolism Adult and adolescent clinical studies Amphetamine - adverse effects Amphetamines Animal cognition Animals Attention - drug effects Basal Nucleus of Meynert - drug effects Basal Nucleus of Meynert - metabolism Basal Nucleus of Meynert - physiopathology Biological and medical sciences Central Nervous System Stimulants - adverse effects Cerebral Cortex - drug effects Cerebral Cortex - metabolism Cerebral Cortex - physiopathology Cholinergic Fibers - drug effects Cognition Disorders - chemically induced Cognition Disorders - metabolism Cognition Disorders - physiopathology Disease Models, Animal Dopamine Male Medical sciences Neural Pathways - drug effects Neural Pathways - metabolism Neural Pathways - physiopathology Neurobiology Neuropharmacology Neuropsychological Tests Pharmacology. Drug treatments Prefrontal Cortex - drug effects Prefrontal Cortex - metabolism Prefrontal Cortex - physiopathology Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) Psychology. Psychoanalysis. Psychiatry Psychomotor Performance - drug effects Psychomotor Performance - physiology Psychopathology. Psychiatry Psychopharmacology Psychoses Rats Rats, Inbred F344 Schizophrenia Schizophrenia - complications Schizophrenia - physiopathology Synaptic Transmission - drug effects Synaptic Transmission - physiology
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