Olanzapine-Induced Weight Gain and Increased Visceral Adiposity is Blocked by Melatonin Replacement Therapy in Rats

The atypical antipsychotic drug olanzapine increases body weight and visceral adiposity in schizophrenia. In rats, aging-associated increased body weight and visceral adiposity are reversed by administration of the pineal hormone melatonin. We asked if melatonin similarly would reverse olanzapine-in...

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Veröffentlicht in:	Neuropsychopharmacology (New York, N.Y.) N.Y.), 2007-02, Vol.32 (2), p.284-288
Hauptverfasser:	RASKIND, Murray A, BURKE, Brianna L, CRITES, Norman J, TAPP, Andre M, RASMUSSEN, Dennis D
Format:	Artikel
Sprache:	eng
Schlagworte:	Abdominal Fat - drug effects Abdominal Fat - metabolism Adult and adolescent clinical studies Aging Animals Antipsychotic Agents - adverse effects Antipsychotics Benzodiazepines - adverse effects Benzodiazepines - antagonists & inhibitors Biological and medical sciences Diabetes Drinking water Drugs Energy Metabolism - drug effects Energy Metabolism - physiology Female Laboratory animals Lipid Metabolism - drug effects Lipid Metabolism - physiology Medical sciences Melatonin Melatonin - blood Melatonin - pharmacology Melatonin - therapeutic use Metabolic diseases Metabolism Neuropharmacology Obesity Obesity - chemically induced Obesity - drug therapy Obesity - metabolism Pharmacology. Drug treatments Pineal Gland - drug effects Pineal Gland - metabolism Pineal Gland - secretion Plasma Psycholeptics: tranquillizer, neuroleptic Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Psychopharmacology Psychoses Psychotropic drugs Rats Rats, Sprague-Dawley Schizophrenia Schizophrenia - drug therapy Up-Regulation - drug effects Up-Regulation - physiology Weight Gain - drug effects Weight Gain - physiology
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