Effects of Systemic Administration of Iptakalim on Extracellular Neurotransmitter Levels in the Striatum of Unilateral 6-Hydroxydopamine-Lesioned Rats

The function of ATP-sensitive potassium (KATP) channels in nigrostriatal pathway in Parkinson's disease (PD) was studied by employing a novel KATP channel opener iptakalim (Ipt). Apomorphine-induced rotation behavior test and microdialysis experiment were carried out in unilateral 6-hydroxydopa...

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Veröffentlicht in:	Neuropsychopharmacology (New York, N.Y.) N.Y.), 2006-05, Vol.31 (5), p.933-940
Hauptverfasser:	SEN WANG, HU, Li-Fang, YUN ZHANG, TAO SUN, SUN, Ye-Hong, LIU, Su-Yi, DING, Jian-Hua, JIE WU, GANG HU
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphate - metabolism Adult and adolescent clinical studies Animals Antihypertensive Agents - pharmacology Apomorphine - pharmacology Astrocytes - drug effects Astrocytes - metabolism Biological and medical sciences Cells, Cultured Corpus Striatum - drug effects Corpus Striatum - metabolism Corpus Striatum - physiopathology Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Disease Disease Models, Animal Dopamine Dopamine - metabolism Dopamine Agonists - pharmacology Extracellular Fluid - drug effects Extracellular Fluid - metabolism Glutamic Acid - metabolism Male Medical sciences Microdialysis Nervous system Nervous system (semeiology, syndromes) Nervous system as a whole Neurobiology Neurology Neurosciences Neurotransmitter Agents - metabolism Neurotransmitter Agents - secretion Organic mental disorders. Neuropsychology Parkinson's disease Parkinsonian Disorders - chemically induced Parkinsonian Disorders - metabolism Parkinsonian Disorders - physiopathology Physiology Pinacidil - pharmacology Potassium Potassium Channels, Inwardly Rectifying - agonists Potassium Channels, Inwardly Rectifying - metabolism Presynaptic Terminals - drug effects Presynaptic Terminals - metabolism Presynaptic Terminals - secretion Propylamines - pharmacology Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Rats Rats, Sprague-Dawley Synaptic Transmission - drug effects Synaptic Transmission - physiology
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