Estimation of D2-like Receptor Occupancy by Dopamine in the Putamen of Hemiparkinsonian Monkeys

To advance understanding of the neurochemical changes in Parkinson's disease (PD), we compared D2-like dopamine receptor occupancy by dopamine in the control and lesioned putamen of four pig-tailed macaques treated unilaterally with MPTP. PET and in vitro binding techniques were used to measure...

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Veröffentlicht in:	Neuropsychopharmacology (New York, N.Y.) N.Y.), 2008-01, Vol.33 (2), p.270-278
Hauptverfasser:	Chefer, Svetlana I, Kimes, Alane S, Matochik, John A, Horti, Andrew G, Kurian, Varughese, Shumway, Dean, Domino, Edward F, London, Edythe D, Mukhin, Alexey G
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine Amphetamines Animals Behavioral Sciences Biological and medical sciences Biological Psychology Brain - diagnostic imaging Brain - drug effects Brain - metabolism Disease Models, Animal Dopamine Dopamine - metabolism Kinetics Macaca nemestrina Medical sciences Medicine Medicine & Public Health Monkeys & apes Neurosciences original-article Parkinson's disease Parkinsonian Disorders - diagnostic imaging Parkinsonian Disorders - metabolism Pets Pharmacotherapy Positron-Emission Tomography Psychiatry Putamen - diagnostic imaging Putamen - metabolism Receptors, Dopamine D2 - metabolism Smoking cessation
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