A PET and ESIPT based fluorescent probe for the imaging of hydrogen sulfide (HS) in live cells and zebrafish
H 2 S is an important signaling molecule in living systems and participates in a series of physiological and pathological processes. In situ and rapid detection of H 2 S levels in living systems is of great importance to the in-depth study of its physiological and pathological roles. Herein, we pres...
Gespeichert in:
| Veröffentlicht in: | Analytical methods 2019-07, Vol.11 (26), p.331-336 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 336 |
|---|---|
| container_issue | 26 |
| container_start_page | 331 |
| container_title | Analytical methods |
| container_volume | 11 |
| creator | Lu, Yaru Dong, Baoli Song, Wenhui Kong, Xiuqi Mehmood, Abdul Hadi Lin, Weiying |
| description | H
2
S is an important signaling molecule in living systems and participates in a series of physiological and pathological processes.
In situ
and rapid detection of H
2
S levels in living systems is of great importance to the in-depth study of its physiological and pathological roles. Herein, we present a new fluorescent probe (
DFAN
) for the detection of H
2
S in live cells and zebrafish. The probe
DFAN
utilized the auxiliary action of the
ortho
-aldehyde group to promote the thiolysis of 2,4-dinitrophenyl ether, and achieved a highly sensitive and selective response to H
2
S. The response mechanism of the probe
DFAN
to H
2
S is an integration of PET and ESIPT mechanisms. Moreover, the probe
DFAN
was successfully used for the fluorescence imaging of H
2
S in live cells and zebrafish.
H
2
S is an important signaling molecule in living systems and participates in a series of physiological and pathological processes. |
| doi_str_mv | 10.1039/c9ay00927b |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_2251710990</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2251710990</sourcerecordid><originalsourceid>FETCH-LOGICAL-c281t-624f37eb2453f30e8dc1c2ac556c13ddf874e3329c3c78dcd5e8d719f0121d653</originalsourceid><addsrcrecordid>eNpFkE1Lw0AQhhdRsFYv3oUBLypE96PJdo9tqbZQsNB68BQ2u7NtSkzqbiLUX29spZ5mYB7emXkIuWb0kVGhnozSO0oVl9kJ6TAZq0glUp0e-4Sek4sQNpQmSiSsQ4oBzMdL0KWF8WI6X0KmA1pwRVN5DAbLGra-yhBc5aFeI-QfepWXK6gcrHfWVyssITSFyy3C3WRxD3kJRf6FYLAowj74GzOvXR7Wl-TM6SLg1V_tkrfn8XI0iWavL9PRYBYZ3md1lPCeExIz3ouFExT71jDDtYnjxDBhrevLHgrBlRFGtkMbt4hkylHGmU1i0SW3h9z29M8GQ51uqsaX7cqU85hJRpWiLfVwoIyvQvDo0q1vv_O7lNH012Y6UoP3vc1hC98cYB_Mkfu3LX4AXDlwCw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2251710990</pqid></control><display><type>article</type><title>A PET and ESIPT based fluorescent probe for the imaging of hydrogen sulfide (HS) in live cells and zebrafish</title><source>Royal Society Of Chemistry Journals 2008-</source><creator>Lu, Yaru ; Dong, Baoli ; Song, Wenhui ; Kong, Xiuqi ; Mehmood, Abdul Hadi ; Lin, Weiying</creator><creatorcontrib>Lu, Yaru ; Dong, Baoli ; Song, Wenhui ; Kong, Xiuqi ; Mehmood, Abdul Hadi ; Lin, Weiying</creatorcontrib><description>H
2
S is an important signaling molecule in living systems and participates in a series of physiological and pathological processes.
In situ
and rapid detection of H
2
S levels in living systems is of great importance to the in-depth study of its physiological and pathological roles. Herein, we present a new fluorescent probe (
DFAN
) for the detection of H
2
S in live cells and zebrafish. The probe
DFAN
utilized the auxiliary action of the
ortho
-aldehyde group to promote the thiolysis of 2,4-dinitrophenyl ether, and achieved a highly sensitive and selective response to H
2
S. The response mechanism of the probe
DFAN
to H
2
S is an integration of PET and ESIPT mechanisms. Moreover, the probe
DFAN
was successfully used for the fluorescence imaging of H
2
S in live cells and zebrafish.
H
2
S is an important signaling molecule in living systems and participates in a series of physiological and pathological processes.</description><identifier>ISSN: 1759-9660</identifier><identifier>EISSN: 1759-9679</identifier><identifier>DOI: 10.1039/c9ay00927b</identifier><language>eng</language><publisher>Cambridge: Royal Society of Chemistry</publisher><subject>Aldehydes ; Danio rerio ; Fluorescence ; Fluorescent indicators ; Hydrogen sulfide ; Physiology ; Positron emission ; Tomography ; Zebrafish</subject><ispartof>Analytical methods, 2019-07, Vol.11 (26), p.331-336</ispartof><rights>Copyright Royal Society of Chemistry 2019</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c281t-624f37eb2453f30e8dc1c2ac556c13ddf874e3329c3c78dcd5e8d719f0121d653</citedby><cites>FETCH-LOGICAL-c281t-624f37eb2453f30e8dc1c2ac556c13ddf874e3329c3c78dcd5e8d719f0121d653</cites><orcidid>0000-0002-6173-9218 ; 0000-0003-0478-7982 ; 0000-0001-8080-4102</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids></links><search><creatorcontrib>Lu, Yaru</creatorcontrib><creatorcontrib>Dong, Baoli</creatorcontrib><creatorcontrib>Song, Wenhui</creatorcontrib><creatorcontrib>Kong, Xiuqi</creatorcontrib><creatorcontrib>Mehmood, Abdul Hadi</creatorcontrib><creatorcontrib>Lin, Weiying</creatorcontrib><title>A PET and ESIPT based fluorescent probe for the imaging of hydrogen sulfide (HS) in live cells and zebrafish</title><title>Analytical methods</title><description>H
2
S is an important signaling molecule in living systems and participates in a series of physiological and pathological processes.
In situ
and rapid detection of H
2
S levels in living systems is of great importance to the in-depth study of its physiological and pathological roles. Herein, we present a new fluorescent probe (
DFAN
) for the detection of H
2
S in live cells and zebrafish. The probe
DFAN
utilized the auxiliary action of the
ortho
-aldehyde group to promote the thiolysis of 2,4-dinitrophenyl ether, and achieved a highly sensitive and selective response to H
2
S. The response mechanism of the probe
DFAN
to H
2
S is an integration of PET and ESIPT mechanisms. Moreover, the probe
DFAN
was successfully used for the fluorescence imaging of H
2
S in live cells and zebrafish.
H
2
S is an important signaling molecule in living systems and participates in a series of physiological and pathological processes.</description><subject>Aldehydes</subject><subject>Danio rerio</subject><subject>Fluorescence</subject><subject>Fluorescent indicators</subject><subject>Hydrogen sulfide</subject><subject>Physiology</subject><subject>Positron emission</subject><subject>Tomography</subject><subject>Zebrafish</subject><issn>1759-9660</issn><issn>1759-9679</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNpFkE1Lw0AQhhdRsFYv3oUBLypE96PJdo9tqbZQsNB68BQ2u7NtSkzqbiLUX29spZ5mYB7emXkIuWb0kVGhnozSO0oVl9kJ6TAZq0glUp0e-4Sek4sQNpQmSiSsQ4oBzMdL0KWF8WI6X0KmA1pwRVN5DAbLGra-yhBc5aFeI-QfepWXK6gcrHfWVyssITSFyy3C3WRxD3kJRf6FYLAowj74GzOvXR7Wl-TM6SLg1V_tkrfn8XI0iWavL9PRYBYZ3md1lPCeExIz3ouFExT71jDDtYnjxDBhrevLHgrBlRFGtkMbt4hkylHGmU1i0SW3h9z29M8GQ51uqsaX7cqU85hJRpWiLfVwoIyvQvDo0q1vv_O7lNH012Y6UoP3vc1hC98cYB_Mkfu3LX4AXDlwCw</recordid><startdate>20190714</startdate><enddate>20190714</enddate><creator>Lu, Yaru</creator><creator>Dong, Baoli</creator><creator>Song, Wenhui</creator><creator>Kong, Xiuqi</creator><creator>Mehmood, Abdul Hadi</creator><creator>Lin, Weiying</creator><general>Royal Society of Chemistry</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7QF</scope><scope>7QO</scope><scope>7QQ</scope><scope>7SE</scope><scope>7SR</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>FR3</scope><scope>H8G</scope><scope>JG9</scope><scope>L7M</scope><scope>P64</scope><orcidid>https://orcid.org/0000-0002-6173-9218</orcidid><orcidid>https://orcid.org/0000-0003-0478-7982</orcidid><orcidid>https://orcid.org/0000-0001-8080-4102</orcidid></search><sort><creationdate>20190714</creationdate><title>A PET and ESIPT based fluorescent probe for the imaging of hydrogen sulfide (HS) in live cells and zebrafish</title><author>Lu, Yaru ; Dong, Baoli ; Song, Wenhui ; Kong, Xiuqi ; Mehmood, Abdul Hadi ; Lin, Weiying</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c281t-624f37eb2453f30e8dc1c2ac556c13ddf874e3329c3c78dcd5e8d719f0121d653</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Aldehydes</topic><topic>Danio rerio</topic><topic>Fluorescence</topic><topic>Fluorescent indicators</topic><topic>Hydrogen sulfide</topic><topic>Physiology</topic><topic>Positron emission</topic><topic>Tomography</topic><topic>Zebrafish</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lu, Yaru</creatorcontrib><creatorcontrib>Dong, Baoli</creatorcontrib><creatorcontrib>Song, Wenhui</creatorcontrib><creatorcontrib>Kong, Xiuqi</creatorcontrib><creatorcontrib>Mehmood, Abdul Hadi</creatorcontrib><creatorcontrib>Lin, Weiying</creatorcontrib><collection>CrossRef</collection><collection>Aluminium Industry Abstracts</collection><collection>Biotechnology Research Abstracts</collection><collection>Ceramic Abstracts</collection><collection>Corrosion Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Copper Technical Reference Library</collection><collection>Materials Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Analytical methods</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lu, Yaru</au><au>Dong, Baoli</au><au>Song, Wenhui</au><au>Kong, Xiuqi</au><au>Mehmood, Abdul Hadi</au><au>Lin, Weiying</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A PET and ESIPT based fluorescent probe for the imaging of hydrogen sulfide (HS) in live cells and zebrafish</atitle><jtitle>Analytical methods</jtitle><date>2019-07-14</date><risdate>2019</risdate><volume>11</volume><issue>26</issue><spage>331</spage><epage>336</epage><pages>331-336</pages><issn>1759-9660</issn><eissn>1759-9679</eissn><abstract>H
2
S is an important signaling molecule in living systems and participates in a series of physiological and pathological processes.
In situ
and rapid detection of H
2
S levels in living systems is of great importance to the in-depth study of its physiological and pathological roles. Herein, we present a new fluorescent probe (
DFAN
) for the detection of H
2
S in live cells and zebrafish. The probe
DFAN
utilized the auxiliary action of the
ortho
-aldehyde group to promote the thiolysis of 2,4-dinitrophenyl ether, and achieved a highly sensitive and selective response to H
2
S. The response mechanism of the probe
DFAN
to H
2
S is an integration of PET and ESIPT mechanisms. Moreover, the probe
DFAN
was successfully used for the fluorescence imaging of H
2
S in live cells and zebrafish.
H
2
S is an important signaling molecule in living systems and participates in a series of physiological and pathological processes.</abstract><cop>Cambridge</cop><pub>Royal Society of Chemistry</pub><doi>10.1039/c9ay00927b</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0002-6173-9218</orcidid><orcidid>https://orcid.org/0000-0003-0478-7982</orcidid><orcidid>https://orcid.org/0000-0001-8080-4102</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1759-9660 |
| ispartof | Analytical methods, 2019-07, Vol.11 (26), p.331-336 |
| issn | 1759-9660 1759-9679 |
| language | eng |
| recordid | cdi_proquest_journals_2251710990 |
| source | Royal Society Of Chemistry Journals 2008- |
| subjects | Aldehydes Danio rerio Fluorescence Fluorescent indicators Hydrogen sulfide Physiology Positron emission Tomography Zebrafish |
| title | A PET and ESIPT based fluorescent probe for the imaging of hydrogen sulfide (HS) in live cells and zebrafish |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-21T03%3A24%3A56IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=A%20PET%20and%20ESIPT%20based%20fluorescent%20probe%20for%20the%20imaging%20of%20hydrogen%20sulfide%20(HS)%20in%20live%20cells%20and%20zebrafish&rft.jtitle=Analytical%20methods&rft.au=Lu,%20Yaru&rft.date=2019-07-14&rft.volume=11&rft.issue=26&rft.spage=331&rft.epage=336&rft.pages=331-336&rft.issn=1759-9660&rft.eissn=1759-9679&rft_id=info:doi/10.1039/c9ay00927b&rft_dat=%3Cproquest_cross%3E2251710990%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2251710990&rft_id=info:pmid/&rfr_iscdi=true |