Evaluation of dicopper azacryptand complexes in aqueous CuAAC reactions and their tolerance toward biological thiols

A series of dicopper azacryptand complexes was evaluated in copper-catalysed azide-alkyne cycloaddition (CuAAC) in water at 37 °C. It was found that they showed high activity at concentrations as low as 5 μM. These dinuclear catalysts were more susceptible toward inhibition by cysteine rather than g...

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Veröffentlicht in:	Dalton transactions : an international journal of inorganic chemistry 2019-07, Vol.48 (26), p.9751-9758
Hauptverfasser:	Tran, Thi V, Couture, Garret, Do, Loi H
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkynes Aqueous solutions Catalysis Catalysts Catalytic activity Coordination compounds Copper Copper compounds Cycloaddition Glutathione Ligands NMR Nuclear magnetic resonance Nucleophiles Substrates Thiols
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