Dihydrostreptomycin Goes through the Mechano-Electric Transduction Channel in Chick Cochlear Hair Cells

Objective: This study evaluated the ability of dihydrostreptomycin (DHSM) to go through the mechano-electric transduction (MET) channels in hair cells under physiological conditions. Materials and Methods: Tall hair cells were isolated from the chick basilar membrane (cochlea). Mechanical stimulatio...

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Veröffentlicht in:	O.R.L. Journal for oto-rhino-laryngology and its related specialties 2009-01, Vol.71 (3), p.157-162
Hauptverfasser:	Kimitsuki, Takashi, Wakasaki, Takahiro, Nawate, Ayako, Komune, Noritaka, Takaiwa, Kazutaka, Ohashi, Mitsuru, Komune, Shizuo
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Bacterial Agents - pharmacokinetics Antibacterial agents Antibiotics. Antiinfectious agents. Antiparasitic agents Biological and medical sciences Birds Cellular biology Chickens Cytoplasm - metabolism Dihydrostreptomycin Sulfate - pharmacokinetics Drug toxicity and drugs side effects treatment Ears & hearing Electricity Hair Cells, Auditory - drug effects Hair Cells, Auditory - physiology In Vitro Techniques Ion Channel Gating - drug effects Ion Channels - antagonists & inhibitors Ion Channels - physiology Mechanotransduction, Cellular - physiology Medical sciences Membrane Potentials - drug effects Membrane Potentials - physiology Membranes Models, Biological Original Paper Otorhinolaryngology. Stomatology Patch-Clamp Techniques Pharmacology. Drug treatments Toxicity: respiratory system, ent, stomatology
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