The role of [alpha]-synuclein in Parkinson's disease: insights from animal models

The abnormal accumulations of fibrillar α-synuclein in Lewy bodies and the mutations in the gene for α-synuclein in familial forms of Parkinson's disease have led to the belief that this protein has a central role in a group of neurodegenerative diseases known as the synucleinopathies. Our unde...

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Veröffentlicht in:	Nature reviews. Neuroscience 2003-09, Vol.4 (9), p.727
Hauptverfasser:	Maries, Eleonora, Dass, Biplob, Collier, Timothy J, Kordower, Jeffrey H, Steece-Collier, Kathy
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer's disease Cell death Disease Enzymes Hypotheses Mutation Neurodegeneration Neurosciences Parkinson's disease Pathogenesis Proteins Toxicity
Online-Zugang:	Volltext
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